The first civilisations to build monumental palaces and urban centres in Europe are more genetically homogenous than expected, according to genomes gathered from archaeological sites around the Aegean. Individuals from the northern Aegean were considerably different by the Middle Bronze Age, sharing half their ancestry with people from the Pontic-Caspian steppe. These populations were highly simil

PLUS. 25 batteritog kommer i udbud. Årsag: Batteritog repræsenterer den mest modne og simple løsning.

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When light hits certain molecules, it dislodges electrons that then move from one location to another, creating areas of positive and negative charge. This 'charge transfer' is highly important in many areas of chemistry, photosynthesis and semiconductor devices and solar cells. A new study reveals how a molecule's structure changes as charge is redistributed, with some chemical bonds getting long

An infrared imager developed by engineers could be used to see through smog and fog; easily locate blood vessels on a patient; and see through silicon wafers to inspect the quality of electronic boards. It is also slim, compact and less costly to fabricate than similar technologies.

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People who trust television and Facebook to provide them with accurate news about the coronavirus pandemic are less knowledgeable about COVID-19, according to a new study. The study assessed people’s knowledge of the virus in the earliest stages of the pandemic. The study in Current Medical Research & Opinion , surveyed 5,948 adults in Pennsylvania between March 25-31, 2020, and found that those

Cerebral small vessel diseases (SVDs) are a group of related pathologies that collectively account for over 25% of ischemic strokes and more than 40% of all dementias (1, 2). Although genetic forms have been identified, sporadic SVDs are the most common and become prevalent with increasing age. The causes of…

A decade ago, four independent groups reported the unanticipated and still surprising result that the bending modulus κ of bilayers of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), unlike other standard lipids, does not increase with addition of cholesterol. This was shown from tube pulling (1, 2) shape analysis (SA) and electro-deformation (ED) of giant…

Based on neutron spin-echo (NSE), solid-state NMR, and molecular dynamics (MD) simulations, we report clear evidence that cholesterol stiffens 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) membranes (1). Contrary to statements by Nagle et al. (2), the relaxations measured by NSE and NMR directly relate to elastic membrane constants (3, 4). While both NSE and…

Transcriptional dysregulation in Huntington’s disease (HD) causes functional deficits in striatal neurons. Here, we performed Patch-sequencing (Patch-seq) in an in vitro HD model to investigate the effects of mutant Huntingtin (Htt) on synaptic transmission and gene transcription in single striatal neurons. We found that expression of mutant Htt decreased the…

Breast cancer patients with increased expression of hypoxia-inducible factors (HIFs) in primary tumor biopsies are at increased risk of metastasis, which is the major cause of breast cancer-related mortality. The mechanisms by which intratumoral hypoxia and HIFs regulate metastasis are not fully elucidated. In this paper, we report that exposure…

Galectin-3 (Gal-3) has a long, aperiodic, and dynamic proline-rich N-terminal tail (NT). The functional role of the NT with its numerous prolines has remained enigmatic since its discovery. To provide some resolution to this puzzle, we individually mutated all 14 NT prolines over the first 68 residues and assessed their…

Tau is a microtubule-associated protein, which promotes neuronal microtubule assembly and stability. Accumulation of tau into insoluble aggregates known as neurofibrillary tangles (NFTs) is a pathological hallmark of several neurodegenerative diseases. The current hypothesis is that small, soluble oligomeric tau species preceding NFT formation cause toxicity. However, thus far, visualizing…

An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precancer systems, while conversely being associated with immune suppression and cytotoxic-cell depletion in human tumors, especially head and neck cancer (HNSC). We present evidence from patient samples and cell lines that alterations in chromosome dosage contribute…

To efficiently integrate cutting-edge terahertz technology into compact devices, the highly confined terahertz plasmons are attracting intensive attention. Compared to plasmons at visible frequencies in metals, terahertz plasmons, typically in lightly doped semiconductors or graphene, are sensitive to carrier density (n) and thus have an easy tunability, which leads to…

A degraded, black-and-white image of an object, which appears meaningless on first presentation, is easily identified after a single exposure to the original, intact image. This striking example of perceptual learning reflects a rapid (one-trial) change in performance, but the kind of learning that is involved is not known. We…

Increasingly, we face compounding and interrelated environmental, socioeconomic, and political crises. Yet our approaches to these problems are often siloed, fragmented, and inadequate. The current pandemic, for instance, continues to collide with a number of other threats to human life and livelihoods. These include violent conflicts, displacement, insect swarms, droughts,…

University of Delaware's Swati Singh is among a small group of researchers across the dark matter community that have begun to wonder if they are looking for the right type of dark matter. Singh, Jack Manley, a UD doctoral student, and collaborators at the University of Arizona and Haverford College, have proposed a new way to look for the particles that might make up dark matter by repurposing ex

Ring microlasers are eyed as potential light sources for photonic applications, but they first must be made more powerful. Combining multiple microlasers into an array solves only half of the problem, as this adds noisy "modes" to the resulting laser light. Now, thanks to the math behind supersymmetry theory, Penn Engineers have achieved single-mode lasing from such an array. By calculating the ne

Engineers and scientists from MIT and Georgia Tech are enabling near real-time modeling of wheels, treads, and desert animals traveling at high speeds across sandy terrains. "Dynamic Resistive Force Theory," or DRFT, provides a path to speedier granular modeling — and help in designing optimal rough terrain vehicles, like Mars and lunar rovers.

The first mental health study of Black communities in Canada has found the majority of Black Canadians display severe depressive symptoms – women, even more so – with racial discrimination confirming the appearance of these signs for nearly all.

The modified mosquitoes should mate with local populations and undermine the survival of offspring.

A previously underappreciated part of the body's natural defense against SARS-CoV-2, called non-RBD-directed antibodies, actually plays a major role in combating the virus, according to a new study. That's good news for scientists designing the next generation of vaccines to protect against variants of the virus or future emerging coronaviruses.

Researchers analyze more palatable alternatives to the kind of social distancing mandates that threw a wrench at how businesses, schools and even family gatherings work.

An individual human can maintain stable social relationships with about 150 people, not more. This is the proposition known as 'Dunbar's number' – that the architecture of the human brain sets an upper limit on our social lives. A new study indicates that a cognitive limit on human group sizes cannot be derived in this manner.

Researchers have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer's disease, a key step toward eventually testing the approach in humans with the neurodegenerative disease.

Many miles of streams and rivers are polluted by toxic metals in acidic runoff draining from abandoned mining sites, and major investments have been made to clean up acid mine drainage at some sites. A new study based on long-term monitoring data from four sites in the western United States shows that cleanup efforts can allow affected streams to recover to near natural conditions within 10 to 15

Not Again The popular financial trading app Robinhood crashed on Tuesday morning after a spike in the price of the cryptocurrency Dogecoin sent a massive influx of users to the app. Robinhood confirmed on Twitter that the partial outage ended after about an hour and a half, during which users were unable to buy or sell Dogecoin as the crypto’s price fluctuated between 40 and a record-breaking 60

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A newly discovered species of extinct ancient turtle uncovered in Madagascar is proof of convergent evolution of suction feeding in turtles.

An Austrian-American research team (University of Vienna, Department Evolutionary Anthropology and Harvard Medical School, Department of Genetics), in collaboration of Hungarian experts from Eötvös Loránd University, has developed a new method that allows the almost non-destructive extraction of genetic material from archaeological human remains. The method allows anthropologists, archaeologists a

A new study investigated the impact of Airbnb's algorithm on racial disparities among Airbnb hosts. Adopting the tool narrowed the revenue gap between White and Black hosts considerably, but because far fewer Black hosts used the algorithm, the revenue gap between White and Black hosts actually increased after the tool's introduction.

Inspired by the powerful eyes of the mantis shrimp, scientists have designed an imaging system that can distinguish between cancerous and healthy tissues during cancer surgery.

Experts at Cincinnati Children's and Stanford screened a library of 4500 compounds to find one, called AG1296, that shows promise as a potential treatment for the rare lung disease PAH.

When access to free and low-cost birth control goes up, the percentage of young women who leave high school before graduating goes down by double-digits, according to new University of Colorado research.

Who made more accurate predictions about the course of the COVID-19 pandemic – experts or the public? A study from the University of Cambridge has found that experts such as epidemiologists and statisticians made far more accurate predictions than the public, but both groups substantially underestimated the true extent of the pandemic.

Deep down in the seafloor anaerobic microbes consume large amounts of methane, a potent greenhouse gas. Even though this process is a crucial element of the global carbon cycle, it is still poorly understood. Scientists from Bremen and Israel now found the solution to a long-standing enigma in this process: why methane carbon isotopes behave so differently than expected. In a joint effort with the

Increased access to birth control led to higher graduation rates among young women in Colorado, according to a study following the debut of the 2009 Colorado Family Planning Initiative (CPFI). The study identified a statistically significant 1.66 percentage-point increase in high school graduation among young women one year after the initiative was introduced.

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The engineers are in the kitchen, again.