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Astronomers have found that supermassive black holes obscured by dust are more likely to grow and release tremendous amounts of energy when they are inside galaxies that are expected to collide with a neighboring galaxy. The new work, led by researchers from Newcastle University, is published in Monthly Notices of the Royal Astronomical Society.
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Hello everyone, I am excited to share the re-release of a research project that I am conducting for my undergraduate thesis. This web application utilizes ChatGPT to generate music compositions based on your input, which are then converted into MIDI format. I want to emphasize that this is primarily a research project, and the quality of the output reflects the current abilities of ChatGPT. Keep
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This is today’s edition of The Download , our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Google is throwing generative AI at everything The news: Google is stuffing powerful new AI tools into tons of its existing products and launching a slew of new ones, including a coding assistant, it announced at its annual I/O conference on Wednesday. What’s
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Last September, Safia Noori; her husband, Fakhruddin Elham; and their four-month-old daughter, Victoria, traveled to Torkham and joined a throng of Afghans waiting to be allowed across by Taliban guards.
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T he extent of the mental-health crisis in the United States today—especially among young adults—is undeniable. The problem started well before the coronavirus pandemic. A survey conducted from 2005 to 2018 of more than 86,000 adolescents found a startling increase in symptoms of depression after 2010. According to an analysis of Pew Research Center data, the most dramatic rise has been among you
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Photographs by Alex Majoli A t the Vatican Museums , the nightly ritual of the keys begins in Room 49A, a tight, windowless chamber, generally referred to as il bunker , which I entered one evening last November from a grassy courtyard as rain began to fall. The keeper of the keys—the clavigero —is a former member of the carabinieri named Gianni Crea. He has a staff of about a dozen, and keeps ne
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There are biases and gaps in both natural history collections and in biodiversity apps and digital tools, research finds. In the race to document the species on Earth before they go extinct, researchers and citizen scientists have assembled billions of records. Most records either come from physical specimens in a museum or digital field observations, but both are useful for detecting shifts in t
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Germany has been thrown around a lot as an example of both what to do and what not to do in terms of addressing global warming by embracing green energy technology. It’s possible to look back now and review the numbers, to see what the effect was of its decision to embrace renewable technology and actively shut down their nuclear power plants. The numbers, I think, tell a pretty clear story. Firs
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01596-8 An interlocked ring pattern of virtual exotic particles has been created in a quantum computer. Plus, an ambitious field trial to vaccinate wild koalas against chlamydia and what record ocean temperatures will mean for wildlife and weather.
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Nature Communications, Published online: 11 May 2023; doi:10.1038/s41467-023-38420-w Electron screening is crucial to interpret inelastic X-ray scattering experiments in materials. Here the authors use a combined analysis based on the Bethe-Salpeter equation and time-dependent density functional theory to calculate the dielectric function and obtain the band gap of liquid water.
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The Atlantic has long been known as an ideas-driven magazine. Now we’re bringing that same ethos to audio. Today we’re introducing Radio Atlantic , The Atlantic’ s flagship podcast, with a new host: senior editor Hanna Rosin. Like the magazine, the show will “road test” the big ideas that both drive the news and shape our culture. Through conversations—and sometimes sharp debates—with the most in
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Researchers say wipes common in schools and care homes exposing people to dangerous chemical group called ‘quats’ Since the pandemic’s outset, the global use of disinfectants has gone through the roof. Clorox dramatically boosted production of its wipe packs to 1.5m a day by mid-2021, and an industry trade group said 83% of consumers surveyed around the same time reported they had used a disinfec
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This article is from The Spark, MIT Technology Review’s weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here. Buckle up, because this week, we’re talking about batteries. Over the past couple of months, I’ve been noticing a lot of announcements about a new type of battery, one that could majorly shake things up if all the promises I’m hearing turn out to be true. T
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Politiskt tal om att "värna barnen" gäller ofta bara vissa barn. Ryssland är ett tydligt exempel på det. Där talas om "barns bästa" – samtidigt som barn bombas, dödas och tas från sina föräldrar i grannlandet Ukraina. Det kan verka som en paradox men är det inte, enligt forskaren Maria Brock. Inlägget dök först upp på forskning.se .
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Nature Communications, Published online: 11 May 2023; doi:10.1038/s41467-023-37824-y The p140Cap adaptor protein is a tumour suppressor associated with improved prognosis in breast cancer. Here, the authors identify a role for p140Cap in preventing the immunosuppressive and pro-tumour function of polymorphonuclear myeloid-derived suppressor cells via downmodulation of the β-Catenin/Tumor Initiati
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Nature Communications, Published online: 11 May 2023; doi:10.1038/s41467-023-38244-8 Removing immunogenic uncapped mRNA from transcribed mRNA can be challenging, but is critical in mRNA research and clinical applications such as vaccines. Here, authors develop hydrophobic photocaged tag-modified cap analogs, which can be used to separate capped mRNA from uncapped mRNA, with subsequent tag removal
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Nature Communications, Published online: 11 May 2023; doi:10.1038/s41467-023-38266-2 Proteins binding to DNA can locally alter DNA damage formation by UV light. Here, Elliott et al. generate high-resolution quantitative UV damage profiles for genomic regions of interest, revealing distinctive damage signatures for specific proteins and elevated UV damage at melanoma mutation hotspots.
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Är det en människa eller en robot som svarar i telefonen? Det är inte helt lätt att avgöra när ai-system får allt mer mänskliga drag. Men utvecklingen kan påverka förtroendet för en samtalspartner, visar forskning. Inlägget dök först upp på forskning.se .
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The course focuses on taming a ubiquitous emotion. But what about addressing its root causes? There are six rules of anger management, says my anger workbook. The first rule: “STOP, think, take a look at the BIG picture.” Then, because why use lower-case when you’ve got capitals: “ANGER MANAGEMENT IS A THINKING PERSON’S GAME!” But thinking, it turns out soon into the course, is discouraged. “I’m
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Open access notables The Intelligence Community Must Evolve To Meet the Reality of Arctic Change is a product of the Wilson Center's subject specalist center The Polar Institute . As its title suggests the report is squarely centered on nitty-gritty details of geopolitical adaptations forced by climate change as they're reflected in national security matters, here (unsurprisingly given the Wilson
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The Environmental Protection Agency (EPA)'s Lead and Copper Drinking Water Rule Revision (LCRR) costs $335 million to implement while generating $9 billion in health benefits annually—far exceeding the EPA's public statements that the LCRR generates $645 million in annual health benefits, according to a new study from researchers at Harvard T.H. Chan School of Public Health. The researchers also e
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Hunterian Museum collection amassed by 18th-century surgeon-anatomist John Hunter includes body parts of humans and animals The relaunch of an extraordinary collection of human and animal specimens gathered in the 18th century by a medical pioneer has prompted the Royal College of Surgeons in England (RCS) to commission research into complex questions about provenance and consent. The collection
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The world's oceans absorb approximately a quarter of all carbon dioxide (CO2) emissions. During absorption, CO2 reacts with seawater and oceanic pH levels fall. This is known as ocean acidification and results in lower carbon ion concentrations. Certain ocean inhabitants use carbon ion to build and sustain their shells. Pteropods, which are important components of the marine ecosystem, are among t
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The pioneering IVF procedure known as mitochondrial donation therapy (MDT) could prevent children from being born with devastating mitochondrial diseases. Madeleine Finlay speaks to Prof Darren Griffin, an expert in genetic diseases and reproduction, about how MDT works, the ethical considerations attached, and what techniques like it could mean for the future of reproduction. Help support our ind
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The pioneering IVF procedure known as mitochondrial donation therapy (MDT) could prevent children from being born with devastating mitochondrial diseases. Madeleine Finlay speaks to Prof Darren Griffin, an expert in genetic diseases and reproduction, about how MDT works, the ethical considerations attached, and what techniques like it could mean for the future of reproduction Read science editor
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The world's oceans absorb approximately a quarter of all carbon dioxide (CO2) emissions. During absorption, CO2 reacts with seawater and oceanic pH levels fall. This is known as ocean acidification and results in lower carbon ion concentrations. Certain ocean inhabitants use carbon ion to build and sustain their shells. Pteropods, which are important components of the marine ecosystem, are among t
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“Our country is being destroyed by stupid people,” former President Donald Trump declared during a CNN town hall tonight, shortly after he endorsed defaulting on the national debt. Trump remains without shame. Neither impeachment nor indictment nor arraignment nor a barely day-old verdict against him in a civil suit can change the fact that he’s still leading the field of Republican presidential
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At this point, we’re approaching peak carelessness when it comes to large tech corporations handling our data. We have a huge data-hungry industry that thrives on the back of our online identity, leaving very little for the imagination. And we actually opted in, since using social media and so on isn’t free. This could lead to one of two outcomes, one being a world fully centered around profiting
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The brain is a complex system comprising a myriad of interacting elements, posing significant challenges in understanding its structure, function, and dynamics. Network science has emerged as a powerful tool for studying such intricate systems, offering a framework for integrating multiscale data and complexity. Here, we discuss the application of network science in the study of the brain, address
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This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here. A verdict against a sexual abuser and the indictment of a con-man fabulist are causes for optimism. But the fundamental indecency of the new American right marches on. First, here are three new stories
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Direct Hit A possible meteorite struck a house in Hopewell, New Jersey on Monday. Though the 4-inch-by-6-inch object hasn't been officially confirmed to be a space rock, it certainly looks like one. The timing also makes sense: according to a Hopewell Township Police Department report , it's believed that the incident may be related to the Eta Aquariids, a meteor shower that reportedly reached it
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The process of speciation allows a single species to diverge into two. Dive into the different versions of this process, including “allopatric speciation” and “sympatric speciation,” and discover how they work.
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Welcome to Up for Debate. Each week, Conor Friedersdorf rounds up timely conversations and solicits reader responses to one thought-provoking question. Later, he publishes some thoughtful replies. Sign up for the newsletter here. Question of the Week A 30-year-old man behaves erratically on an afternoon New York City subway train. In an aggressive tone, in the midst of an apparent mental-health c
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Fries With That? Wendy's is the latest fast food chain to get in on the AI craze. The company has announced that it will let an AI chatbot take customer orders at the drive-thru window. The Wall Street Journal reports that the Ohio-based company will be introducing an AI chatbot, developed by Google's cloud-computing division, to one of its Columbus locations as it tests out whether the technolog
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In a new collaboration, scientists at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) have identified the types of microbes that associate with engineered oilcane. Further exploration of the oilcane microbiome may reveal opportunities to leverage plant-microbial interactions in these feedstocks, which could increase oil yields for sustainable bioenergy production.
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Jonathan Pruitt An investigation at McMaster University found that Jonathan Pruitt, a behavioral ecologist by training who has had 15 papers retracted in the last three years, “engaged in fabrication and falsification” including duplicating data, according to summarized findings sent to coauthors. Kate Laskowski, an assistant professor at the University of California, Davis, shared on Twitter the
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In a new collaboration, scientists at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) have identified the types of microbes that associate with engineered oilcane. Further exploration of the oilcane microbiome may reveal opportunities to leverage plant-microbial interactions in these feedstocks, which could increase oil yields for sustainable bioenergy production.
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Falling Slowly NASA's Hubble Space Telescope is slowly falling to its death — but now , a couple of startups have a solution that may just be crazy enough to work. As Gizmodo reports, the Tokyo-based Astroscale startup and California's Momentus Space have drafted a joint plan to save Hubble, which has been slowly sinking further into low-Earth orbit since it was first launched 33 years ago. At th
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Abstract High-entropy alloy (HEA) nanocrystals have attracted extensive attention in catalysis. However, there are no effective strategies for synthesizing them in a controllable and predictable manner. With quinary HEA nanocrystals made of platinum-group metals as an example, we demonstrate that their structures with spatial compositions can be predicted by quantitatively knowing the reduction k
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Abstract Intracellular deposition of α-synuclein and tau are hallmarks of synucleinopathies and tauopathies, respectively. Recently, several dye-based imaging probes with selectivity for tau aggregates have been developed, but suitable imaging biomarkers for synucleinopathies are still unavailable. Detection of both of these aggregates early in the disease process may allow for prophylactic thera
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Abstract As governments and industry turn to increased use of automated decision systems, it becomes essential to consider how closely such systems can reproduce human judgment. We identify a core potential failure, finding that annotators label objects differently depending on whether they are being asked a factual question or a normative question. This challenges a natural assumption maintained
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Abstract Here, we reported the complete profiling of the crotonylation proteome in common wheat. Through a combination of crotonylation and multi-omics analysis, we identified a TaPGK associated with wheat cold stress. Then, we confirmed the positive role of TaPGK-modulating wheat cold tolerance. Meanwhile, we found that cold stress induced lysine crotonylation of TaPGK. Moreover, we screened a l
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Abstract The main carcinogen for keratinocyte skin cancers (KCs) such as basal and squamous cell carcinomas is ultraviolet (UV) radiation. There is growing evidence that accumulation of mutations and clonal expansion play a key role in KC development. The relationship between UV exposure, epidermal mutation load, and KCs remains unclear. Here, we examined the mutation load in both murine ( n = 23
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Abstract Neural progenitor cells (NPCs) have the capability to self-renew and differentiate into neurons and glial cells. In the adult brain, NPCs are found near brain microvascular networks (BMVNs) in specialized microenvironments called the neurovascular niche (NVN). Although several in vitro NVN models have been previously reported, most do not properly recapitulate the intimate cellular inter
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Abstract Digital information, when converted into a DNA sequence, provides dense, stable, energy-efficient, and sustainable data storage. The most stable method for encapsulating DNA has been in an inorganic matrix of silica, iron oxide, or both, but are limited by low DNA uptake and complex recovery techniques. This study investigated a rationally designed thermally responsive functionally grade
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Abstract Semicrystalline polymers are solids that are supposed to flow only above their melting temperature. By using confinement within nanoscopic cylindrical pores, we show that a semicrystalline polymer can flow at temperatures below the melting point with a viscosity intermediate to the melt and crystal states. During this process, the capillary force is strong and drags the polymer chains in
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Abstract Mechanical behaviors of a polymer gel are coupled with its swelling behavior. It has been known that typical hydrogels display extension-induced swelling and drying-induced stiffening, called normal mechanical-swelling coupling. In this study, we experimentally found that highly extended double-network (DN) hydrogels exhibit abnormal inverse mechanical-swelling coupling such as extension
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Abstract Ring-forming AAA + chaperones solubilize protein aggregates and protect organisms from proteostatic stress. In metazoans, the AAA + chaperone Skd3 in the mitochondrial intermembrane space (IMS) is critical for human health and efficiently refolds aggregated proteins, but its underlying mechanism is poorly understood. Here, we show that Skd3 harbors both disaggregase and protein refolding
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Abstract Most state-of-art models project a reduced equatorial Pacific east-west temperature gradient and a weakened Walker circulation under global warming. However, the causes of this robust projection remain elusive. Here, we devise a series of slab ocean model experiments to diagnostically decompose the global warming response into the contributions from the direct carbon dioxide (CO 2 ) forc
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Abstract Earth’s life-sustaining oceans harbor diverse bacterial communities that display varying composition across time and space. While particular patterns of variation have been linked to a range of factors, unifying rules are lacking, preventing the prediction of future changes. Here, analyzing the distribution of fast- and slow-growing bacteria in ocean datasets spanning seasons, latitude,
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Abstract Understanding the diffusion of small molecules in polymer microsystems is of great interest in diverse fundamental and industrial research. Despite the rapidly advancing optical imaging and spectroscopic techniques, entities under investigation are usually limited to flat films or bulky samples. We demonstrate a route to in situ detection of diffusion dynamics in polymer micro-objects by
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Abstract An obstacle to conducting diverse bioorthogonal reactions in living systems is the sensitivity of artificial metal catalysts. It has been reported that artificial metallocatalysts can be assembled in “cleaner” environments in cells for stabilized performance, which is powerful but is limited by the prerequisite of using specific cells. We report here a strategy to establish membrane-anch
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Abstract In nature, cyclopropylcarbinyl cation is often involved in cationic cascade reactions catalyzed by natural enzymes to produce a great number of structurally diverse natural substances. However, mimicking this natural process with artificial organic catalysts remains a daunting challenge in synthetic chemistry. We report a small molecule–catalyzed asymmetric rearrangement of cyclopropylca
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Abstract Communication between infected cells and cells in the surrounding tissue is a determinant of viral spread. However, it remains unclear how cells in close or distant proximity to an infected cell respond to primary or secondary infections. We establish a cell-based system to characterize a virus microenvironment, distinguishing infected, neighboring, and distal cells. Cell sorting, micros
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Abstract A fundamental feature of cell signaling is the conversion of extracellular signals into adaptive transcriptional responses. The role of RNA modifications in this process is poorly understood. The small nuclear RNA 7SK prevents transcriptional elongation by sequestering the cyclin dependent kinase 9/cyclin T1 (CDK9/CCNT1) positive transcription elongation factor (P-TEFb) complex. We found
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Abstract Despite the high lethality of colorectal cancers (CRCs), only a limited number of genetic risk factors are identified. The mammalian ssDNA-binding protein complex CTC1-STN1-TEN1 protects genome stability, yet its role in tumorigenesis is unknown. Here, we show that attenuated CTC1/STN1 expression is common in CRCs. We generated an inducible STN1 knockout mouse model and found that STN1 d
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Abstract Dynamic signal transduction requires the rapid assembly and disassembly of signaling complexes, often mediated by phosphoprotein binding modules. The guanylate kinase-like (GK) domain of the membrane-associated guanylate kinases (MAGUKs) is such a module orchestrating signaling at cellular junctions. The MAGI subfamily of MAGUKs contains a truncated GK domain with unknown structure and f
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Abstract The molecular and functional contributions of intratumoral nerves to disease remain largely unknown. We localized synaptic markers within tumors suggesting that these nerves form functional connections. Consistent with this, electrophysiological analysis shows that malignancies harbor significantly higher electrical activity than benign disease or normal tissues. We also demonstrate phar
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Abstract The climate response to biomass burning emissions from the 2019–2020 Australian wildfire season is estimated from two 30-member ensembles using CESM2: one of which incorporates observed wildfire emissions and one that does not. In response to the fires, an increase in biomass aerosol burdens across the southern hemisphere is simulated through late 2019 and early 2020, accompanied by an e
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Abstract Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women. LAM cells carry TSC1/TSC2 mutations, causing mTORC1 hyperactivation and uncontrolled cell growth. mTORC1 inhibitors stabilize lung function; however, sustained efficacy requires long-term administration, and some patients fail to tolerate or respond to therapy. Although the genetic basis
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The dairy industry has seen a revolution over the past two decades in fertility success within herds. Widely adopted fertility programs are at the heart of this leap forward, along with the industry's increased understanding—and optimization—of the holistic interactions among the body condition, overall health, and fertility of a dairy cow.
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The dairy industry has seen a revolution over the past two decades in fertility success within herds. Widely adopted fertility programs are at the heart of this leap forward, along with the industry's increased understanding—and optimization—of the holistic interactions among the body condition, overall health, and fertility of a dairy cow.
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The coronavirus genome is 30,000 letters long, encoding more than two dozen different proteins that enable the virus to hijack our cells. Of these, spike gets all the glory and infamy; it is the protein targeted by vaccines, and it is the protein that keeps shape-shifting in new variants. But lately, something strange has been happening with another protein called ORF8, once thought to be a cruci
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Corn tar spot is a new disease causing significant yield loss in the United States. The lack of information about the pathogen and epidemiology of the disease—which was first reported in the U.S. in 2015 and has since spread to multiple states, including Minnesota in 2019—has made it difficult to diagnose and treat properly. Corn tar spot also appears similar to other leaf diseases and abiotic dis
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Scientists aboard Schmidt Ocean Institute's R/V Falkor (too) have returned from an expedition to study the impact of climate change on deep water corals. Scientists from the mainland U.S. and Puerto Rico found greater biodiversity than previously known in Puerto Rican waters and may have identified several suspected new species of corals, collecting over 300 samples across 75 different species. Re
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An increasing number of Floridians agree that human actions are causing climate change, including a record number of Florida Republicans, according to a new survey from Florida Atlantic University. This finding reinforces the trend observed in the prior seven Florida Climate Resilience Surveys, conducted by FAU's Center for Environmental Studies within the Charles E. Schmidt College of Science.
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The development of quantum computing means that the use of classic cryptography for secure communications is in danger of becoming obsolete. Quantum cryptography, on the other hand, uses the laws of quantum mechanics to ensure total security. One example of this is quantum key distribution, which enables two parties to secure a message via a random secret key.
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To make it possible for cellular agriculture—the process of growing meat in bioreactors—to feed millions of people, several technical challenges will have to be overcome. Muscle cells from chicken, fish, cows, and other food sources will have to be grown to produce millions of metric tons per year. Toward this goal, researchers at Tufts University Center for Cellular Agriculture (TUCCA) have devel
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Colistin is a cationic cyclic peptide that disrupts bacterial cell membranes of Gram-negative bacteria. It is one of the few remaining antibiotics of last resort for use against infections with multidrug-resistant bacteria. Hence, the recent global detection of transferable mobile colistin resistance gene families in a wide range of multi-resistant Gram-negative bacteria isolated from all kinds of
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Corn tar spot is a new disease causing significant yield loss in the United States. The lack of information about the pathogen and epidemiology of the disease—which was first reported in the U.S. in 2015 and has since spread to multiple states, including Minnesota in 2019—has made it difficult to diagnose and treat properly. Corn tar spot also appears similar to other leaf diseases and abiotic dis
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Scientists aboard Schmidt Ocean Institute's R/V Falkor (too) have returned from an expedition to study the impact of climate change on deep water corals. Scientists from the mainland U.S. and Puerto Rico found greater biodiversity than previously known in Puerto Rican waters and may have identified several suspected new species of corals, collecting over 300 samples across 75 different species. Re
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To make it possible for cellular agriculture—the process of growing meat in bioreactors—to feed millions of people, several technical challenges will have to be overcome. Muscle cells from chicken, fish, cows, and other food sources will have to be grown to produce millions of metric tons per year. Toward this goal, researchers at Tufts University Center for Cellular Agriculture (TUCCA) have devel
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Colistin is a cationic cyclic peptide that disrupts bacterial cell membranes of Gram-negative bacteria. It is one of the few remaining antibiotics of last resort for use against infections with multidrug-resistant bacteria. Hence, the recent global detection of transferable mobile colistin resistance gene families in a wide range of multi-resistant Gram-negative bacteria isolated from all kinds of
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For three decades, most Alzheimer’s researchers have stuck by the theory that aggregations of proteins called amyloid plaques cause the disease. Researchers investigating alternative possibilities have faced resistance from the biomedical establishment for decades, but intriguing theories about the role of defects in protein processing and the immune system have emerged. Listen to the player belo
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A new study led by City, University of London suggests that the introduction of the Research Excellence Framework (REF) to measure the research performance of UK universities has led to significant increases in the quantity of their high-quality published research, but not in the output of active academics, and that it must do more to support university research strategies.
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Spread across 106 acres in southcentral Utah, the Pando aspen grove resembles a forest but is actually a single organism with more than 47,000 genetically identical aspen stems connected at the root. Pando is the world's largest tree by weight and land mass. Research suggests Pando has been regenerating for 9,000 years, making it one of the oldest organisms on Earth.
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Google is stuffing powerful new AI tools into tons of its existing products and launching a slew of new ones, including a coding assistant, it announced at its annual I/O conference today. Billions of users will soon see Google’s latest AI language mode, PaLM 2, integrated into over 25 products like Maps, Docs, Gmail, Sheets, and the company’s chatbot, Bard. For example, people will be able to si
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Spread across 106 acres in southcentral Utah, the Pando aspen grove resembles a forest but is actually a single organism with more than 47,000 genetically identical aspen stems connected at the root. Pando is the world's largest tree by weight and land mass. Research suggests Pando has been regenerating for 9,000 years, making it one of the oldest organisms on Earth.
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Based Celebrities Being trapped inside a small Mars habitat for months if not years at a time won't be the faint of heart. It's a journey that will require cool minds, quick wits, and plenty of technological know-how. In a wacky take on the concept, Fox announced that it's pitting a unusual mix of 12 celebrities — including disgraced Tour de France champion Lance Armstrong and "Modern Family" act
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Implantable bioelectrodes are electronic devices that can monitor or stimulate biological activity by transmitting signals to and from living biological systems. Such devices can be fabricated using various materials and techniques. But, because of their intimate contact and interactions with living tissues, selection of the right material for performance and biocompatibility is crucial. In recent
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We often come to an understanding of what causes a disease. We know, for example, that cancers are caused by mutations at critical locations in the genome, resulting in loss of control of cell growth. We know that the onset of Huntington's disease, and other diseases that lead to muscle wasting and loss of coordination and balance, are linked to the expansion of short, repeated DNA sequences.
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Nonfood, plant-based biofuels have potential as a green alternative to fossil fuels, but the enzymes required for production are too inefficient and costly to produce. However, new research published in Chemical Science is shining a light on enzymes from fungi that could make biofuels economically viable.
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We often come to an understanding of what causes a disease. We know, for example, that cancers are caused by mutations at critical locations in the genome, resulting in loss of control of cell growth. We know that the onset of Huntington's disease, and other diseases that lead to muscle wasting and loss of coordination and balance, are linked to the expansion of short, repeated DNA sequences.
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Elizabeth Holmes isn’t fooling anyone. Well, almost anyone. The convicted fraudster and founder of the defunct medical start-up Theranos, is waiting to begin an 11-year sentence in federal prison. She received this punishment for misleading investors about her lab-in-a-box technology, which she claimed could run hundreds of tests on a few drops of blood. In reality, when Theranos’s Edison device
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Pull Over Now A Tesla Cybertruck prototype decided to stop and smell the roses during a test journey. The oddly shaped vehicle was spotted by eagle-eyed onlookers outside Corpus Christi, Texas, earlier this week, Electrek reports , near where the company celebrated the opening of its new lithium refining facility on Monday. A video shows a number of employees surrounding the stranded truck. While
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We all remember 2020. At the grocery store, toilet paper shelves were empty. Cleaning supplies and disinfectants were treasured finds. Rattled consumers, concerned that they would run out of essential items, swiftly stockpiled products until they disappeared from shelves. In the media, it was referred to as "panic buying."
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This is a re-post from Yale Climate Connections Electric vehicle (EV) sales are surging in many countries around the world, including the United States. According to the Department of Energy , EVs accounted for just 1% of new U.S. car sales in 2017. That share surpassed 3% in 2021 and approached 6% in 2022. Though the U.S. remains well below the global average EV share of new car sales, which exc
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In space, cataclysmic events happen to stars all the time. Some explode as supernovae, some get torn apart by black holes, and some suffer other fates. But when it comes to planets, stars turn the tables. Then it's the stars who get to inflict destruction.
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One of the Writers Guild of America's demands in its current strike is for studios to regulate the use of artificial intelligence for creating, writing and rewriting TV and movie scripts and other material.
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Climate change is increasingly a major consideration for business leaders as they plan for future investment and work to improve their firm's competitiveness. The private sector, as both a major emitter of greenhouse gases (GHGs) and an important source of innovation, must play an essential role in society's efforts to decarbonize, and ultimately, transition to net zero by 2050.
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To better understand observations of the most distant galaxies, an international team of astronomers has built a sample of local galaxies which can be studied in much higher detail. In a newly published study they show how the amount of light that escapes from a galaxy is connected to its physical properties. The result has implication for how we interpret observations of galaxies in the early uni
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Watching distracting videos helps kids with cancer hold still and avoid the need for anesthesia during radiation treatments, a new study finds. Video-based distraction also reduces children’s anxiety and improves their quality of life as they undergo radiation therapy. The study’s participants, 81 children who were 3 to 10 years old, were being treated for various forms of cancer at 10 pediatric
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A new discovery about the structure of melanin brings scientists one step closer to developing a new, potentially ultra-protective sunscreen derived from a biological substance found in nearly all organisms. The new research marks a major advance in understanding the fundamental structure of melanin and one of its components that turns light into heat, protecting the body from sun damage . Melani
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For a moment, it read like a loss. The first question asked on the verdict form in the matter of E. Jean Carroll v. Donald J. Trump concerned the writer’s battery allegation against the former president. Had she proved that Trump had raped her? “NO,” came the answer. But the form continued: Had Carroll proved that Trump had sexually abused her? YES. Had she proved that she had been injured as a r
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Across multiple fronts, Democrats and their allies are stiffening their resistance to a surge of Republican-led book bans. President Joe Biden and Vice President Kamala Harris in the past month have conspicuously escalated their denunciations of the book bans proliferating in schools across the country, explicitly linking them to restrictions on abortion and voting rights to make the case that “M
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Updated at 2:25 p.m. ET on May 10, 2023 George Santos was a young man in a hurry, and when he came from nowhere to win a seat in the U.S. House last November, he must have thought he’d arrived. But an indictment filed yesterday in federal court on Long Island suggests that his actual destination might be not the U.S. Capitol but a more restrictive federal-government facility. For Santos to be ind
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The 147th annual Westminster Kennel Club Dog Show took place in New York City over the past several days, hosting about 4,000 dogs of more than 200 different breeds and varieties. This year’s Best in Show was awarded to Buddy Holly, a petit basset griffon Vendéen. Below are images from this year’s competition, held at the USTA Billie Jean King National Tennis Center.
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Vacations can be quite enjoyable. Visiting historic cities, lounging in the sun on a tropical beach, or snuggling up at a cozy mountain resort. But while the destinations are great, traveling itself can be a chore. Crowds, cramped flights, delays. It would be great if there were some short cut to our destination. Now imagine the vacationers of a galactic empire. It's great to visit the diamond sho
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According to a study published in Advanced Optical Materials, Prof. Ding Junfeng and his team at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences showed that the semiconductor lead iodide (PbI2) undergoes a transition to a semi-metallic state when subjected to pressure. This transition is accompanied by an improvement in photoelectric properties and an extension of the s
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The ocean absorbs a quarter of the CO₂ given out by human activities, playing a major role in slowing climate change. To have a better grasp of these processes is crucial to understand the ocean's role in the global climate system and to better foresee disruptions caused by the changing climate.
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Doctor Octavius A Japanaese robotics company called Jizai has come up with a strange robotic limb contraption called, appropriately, Arms that can give the wearer extra sets of arms like Marvel's iconic Spider-Man villain Doctor Octopus — well, sort of. An artfully shot promotional video shows two models demonstrating the system's capabilities by dancing to some classical music, allowing the appe
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A team of researchers, jointly led by the Universities of Oxford and Cambridge, have discovered that a solar cell material—bismuth oxyiodide (BiOI)—is capable of detecting X-ray dose rates over 250 times lower than the current best performing detectors used commercially. This has the potential to make medical imaging safer, and open up new opportunities in non-invasive diagnostics, such as X-ray v
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The world would look very different without multicellular organisms—take away the plants, animals, fungi, and seaweed, and Earth starts to look like a wetter, greener version of Mars. But precisely how multicellular organisms evolved from single-celled ancestors remains poorly understood. The transition happened hundreds of millions of years ago, and early multicellular species are largely lost to
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The world would look very different without multicellular organisms—take away the plants, animals, fungi, and seaweed, and Earth starts to look like a wetter, greener version of Mars. But precisely how multicellular organisms evolved from single-celled ancestors remains poorly understood. The transition happened hundreds of millions of years ago, and early multicellular species are largely lost to
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The determination of plant vessel structure is fundamental for further understanding vascular function in different plant groups. Vessel dimorphism may be an important hydraulic strategy and ecological adaptation of plants. Previous studies have found that lianas, a common tropical and subtropical plant growth form, generally have larger vessel diameters than co-occurring trees. However, these res
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Discarded or drifting in the ocean, plastic debris can accumulate on the water's surface, forming floating islands of garbage. Although it's harder to spot, researchers suspect a significant amount also sinks. In a new study in ACS' Environmental Science & Technology, one team used computer modeling to study how far bits of lightweight plastic travel when falling into the Mediterranean Sea. Their
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A new study found that air pollution from the oil and gas sector in the United States has substantial adverse impacts on air quality, human health, and health costs. The findings show that the pollutants nitrogen oxide (NO2), fine particulate matter (PM2.5) and ozone (O3) from U.S. oil and gas production contributed to 7,500 excess deaths, 410,000 asthma attacks, and 2,200 new cases of childhood a
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Researchers have developed a new class of integrated photonic devices — 'leaky-wave metasurfaces' — that convert light initially confined in an optical waveguide to an arbitrary optical pattern in free space. These are the first to demonstrate simultaneous control of all four optical degrees of freedom. Because they're so thin, transparent, and compatible with photonic integrated circuits, they
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The determination of plant vessel structure is fundamental for further understanding vascular function in different plant groups. Vessel dimorphism may be an important hydraulic strategy and ecological adaptation of plants. Previous studies have found that lianas, a common tropical and subtropical plant growth form, generally have larger vessel diameters than co-occurring trees. However, these res
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Fungi produce metabolites that humans have used to improve health. For example, they secrete penicillin, which is then purified and used as an antibiotic for humans, leading to the development of many other antibiotics. However, the ecology of fungal metabolites in microbial communities is not well understood. In a new study, researchers use cheese rinds to demonstrate that fungal antibiotics can
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06063-y A phase I clinical trial of an adjuvant personalized mRNA neoantigen vaccine, autogene cevumeran, in patients with pancreatic ductal carcinoma demonstrates that the vaccine can induce T cell activity that may correlate with delayed recurrence of disease.
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Fungi produce metabolites that humans have used to improve health. For example, they secrete penicillin, which is then purified and used as an antibiotic for humans, leading to the development of many other antibiotics. However, the ecology of fungal metabolites in microbial communities is not well understood. In a new study, researchers use cheese rinds to demonstrate that fungal antibiotics can
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Rhinoceros belong to a mammalian order called odd-toed ungulates that also include horses and tapirs. They are found in Africa and Asia. Until recently, evidence suggested that throughout their evolutionary history, gammaretroviruses such as Murine leukemia virus had not colonized their genomes, unlike most other mammalian orders.
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People with type 2 diabetes who have full chewing function have a blood glucose level that is significantly lower than patients whose ability to chew effectively is impaired, a new study shows. The retrospective study, published in PLOS ONE , looked at data gathered from 94 patients with type 2 diabetes who had been seen at an outpatient clinic in a hospital in Istanbul, Turkey. The researchers d
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At first, it was just Michael J. Fox’s pinky that was fluttering. Years later, his whole upper body was rocking back and forth. Now, at age 61, Fox struggles to walk down the street without falling over. No amount of money or celebrity can change the manifestations of his degenerative neurological condition, Parkinson’s disease. He routinely breaks bones: in his hand, his arm, his face. “You lose
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The last public execution in the United States was a raucous and tawdry affair. By the time 20,000 people poured into Owensboro, Kentucky, for the 1936 hanging of Rainey Bethea, a Black man in his 20s who had pleaded guilty to the rape of a 70-year-old white woman, public executions had been on the wane in America for several decades. Reformers worried about the brutalizing effect of such violenc
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For as long as I can remember, I have been that friend —the one who, from May to November, gets invited to every outdoor soiree. It’s not because I make the best desserts, even though I do . It’s because, with me around, the shoes can come off and the DEET can stay sheathed: No one else need fear for their blood when the mosquitoes are all busy biting me. Explanations abound for why people like m
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After many trials, the judge will dismiss the jurors by thanking them for their time and public service. These words of gratitude are usually a formality, a polite nod to a key feature of our democratic process: defendants’ right, under the Seventh Amendment , to judgment by their peers in “Suits at common law.” Federal Judge Lewis A. Kaplan also offered a piece of practical advice to the Manhatt
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When considering laws, workplace policies or school rules, one might take notice of whom they impact. New research from the University of New Mexico has found whether it's interventions to reduce workplace bullying, help with weight loss, or enhance student engagement, people show a gender bias in how they feel.
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The Federal Drug Administration (FDA) just gave the OK for genetically-modified pig sausages to enter the food supply. Gene-hacked hot dogs for all! The pork sausage in question was created out of meat from two-year-old pigs that were genetically modified at Washington State University (WSU). The team behind the project was led by Jon Oatley, a professor in the School of Molecular Biosciences in
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Researchers say mosquitoes may be attracted to soap because when not feeding on blood they supplement sugar intake with nectar Lathering up with soap might seem a reasonable mosquito-evasion strategy on the basis that if they can’t smell you, they can’t bite you. However, a study suggests that rather than helping you go incognito, soapy fragrances could make you a more attractive target, with mos
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06046-z This study illustrates long interspersed nuclear element-1 retrotransposition-induced somatic mosaicism in normal cells and provides insights into the genomic and epigenomic regulation of transposable elements over the human lifetime.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06044-1 A study presents evidence to support a model in which liquid–liquid phase separation of components of the transport machinery mediates formation of transient protein transport channels on peroxisomes.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06049-w Cryogenic electron microscopy images of a spliceosome complex undergoing catalytic activation provide mechanistic insight into how the two ATP-dependent RNA helicases involved in this process, PRP2 and Aquarius, work together.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05978-w Lithographically patterned perovskite nanocrystal arrays were used to determine radiation vectors from X-rays to visible light and the emission colours of the nanoparticles was used to create images of three-dimensional objects and for phase-contrast imaging.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06047-y Gene expression analysis in muscle tissues showed upregulation of ectodysplasin A2 receptor in tumour-bearing mice and patients with cachectic cancer, and thus therapeutic targeting of relevant pathways may be beneficial in prevention of muscle loss.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05898-9 The authors report a high-throughput combinatorial printing method capable of fabricating materials with compositional gradients at microscale spatial resolution, demonstrating a variety of high-throughput printing strategies and applications in combinatorial doping, functional grading and chemical reaction.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05976-y Comparisons within the human pangenome establish that homologous regions on short arms of heterologous human acrocentric chromosomes actively recombine, leading to the high rate of Robertsonian translocation breakpoints in these regions.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06052-1 After 600 rounds of selection, anaerobic snowflake yeast evolved to be macroscopic, becoming around 20,000 times larger (approximately mm scale) and about 10,000-fold more biophysically tough, while retaining a clonal multicellular life cycle.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05896-x An initial draft of the human pangenome is presented and made publicly available by the Human Pangenome Reference Consortium; the draft contains 94 de novo haplotype assemblies from 47 ancestrally diverse individuals.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05974-0 The CIP2A–TOPBP1 complex tethers fragmented chromosomes from micronuclei for asymmetric mitotic inheritance, explaining distinct patterns of chromosome rearrangements in cancers and genomic disorders.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05866-3 Salinity reconstructions show that Indian Ocean surface salinity increased during glacial periods and that the release of this water via the Agulhas Leakage during deglaciation can trigger abrupt changes in the Atlantic Meridional Overturning Circulation.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06050-3 Integrative structural biology combining quantitative live imaging, cryo-correlative microscopy, subtomogram averaging and molecular modelling enables in situ determination of the structure of the endoplasmic reticulum–mitochondria encounter complex in yeast.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05901-3 Investigation of the physical conditions of the circumgalactic medium led to detection of two compact [C ii]-emitting galaxies with narrow linewidths at a redshift of 5.7, associated with a complex, high-ionization C iv absorption system.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-05885-0 A loophole-free violation of Bell’s inequality with superconducting circuits shows that non-locality is a viable new resource in quantum information technology realized with superconducting circuits, promising many potential applications.
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Nature, Published online: 10 May 2023; doi:10.1038/s41586-023-06053-0 Complementary single-cell and single-nucleus transcriptomic analyses of Zea mays, Sorghum bicolor and Setaria viridis root cells provide insights into the evolution of cell types and gene modules that control key traits in these important crop species.
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01488-x Superconducting quantum bits, a promising platform for future quantum computers, have been entangled over a separation of 30 metres, with a performance that enabled the demonstration of a milestone in quantum physics.
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01490-3 A pangenome is a collection of DNA sequences that reveals genetic variation between individuals. Four scientists discuss the generation of a human pangenome, and what insights can be gained from it.
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01528-6 The processing of messenger RNA during splicing requires the activity of a complex of RNAs and proteins termed the spliceosome. Structural data shed light on previously mysterious aspects of splicing in humans.
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01526-8 Efforts to tackle pancreatic cancer by harnessing immune cells have had limited success. A clinical trial reports promising results from testing a personalized approach to boosting immune responses to such tumours.
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01366-6 Most light-field sensors — devices that detect the angles of incoming light rays to reconstruct 3D scenes — can detect light only in the ultraviolet and visible wavelength ranges. A newly developed light-field sensor comprising perovskite nanocrystals encodes the angles of incoming visible-light beams and X-rays as different co
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01489-w Analysis of microfossils in marine sediments spanning the past 1.2 million years suggests that increased intrusion of highly saline waters from the Indian Ocean into the South Atlantic propelled Earth’s deglaciations during this period.
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Nature, Published online: 10 May 2023; doi:10.1038/d41586-023-01527-7 Muscle loss during chronic disease is a life-threatening condition for which there is no effective treatment. The identification of an underlying molecular mechanism might offer new therapeutic targets.
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Nature, Published online: 05 May 2023; doi:10.1038/d41586-023-01570-4 A new, phosphate-storing organelle discovered inside fruit-fly intestines. Plus, controversy over COVID genome database GISAID and what a promising trial of the Alzheimer’s drug donanemab means for treatments.
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In Brief: The amount of CO 2 in the atmosphere is measured at Mauna Loa Observatory, Hawaii, and all around the world. NASA also measures CO 2 from space. Data from around the planet all shows the same upward trend. The longest record of direct measurements of carbon dioxide (CO 2 ) in Earth’s atmosphere comes from Mauna Loa Observatory in Hawaii, operated by the National Oceanic and Atmospheric
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Solar flares and coronal mass ejections (CME) are two of the most energetic processes in the solar system, showering the Earth's magnetic field with billions of tons of highly energetic plasma gas, potentially disrupting power grids, satellites and communications networks. Understanding the underlying particle acceleration process involved in large solar energetic particle (SEP) events like these
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Calcium homeostasis, involving the flow of calcium ions within cells, is essential for cell signaling and function. Importantly, calcium enters the cellular powerplants known as mitochondria, where it fine tunes energy production. Now, new research at the Lewis Katz School of Medicine at Temple University shows that, when it comes to mitochondria, calcium has another, vital function—serving as a r
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A new study published in PNAS Nexus explores the role of the dynamin protein DYN-1 in axonal fusion. The axon is a long, thin protrusion of nerve cells that carries electrical impulses. Severed axons can be repaired by a highly efficient regrowth process known as axonal fusion. Previous research has shown that molecules involved in apoptosis—programmed cell death—are also involved in axonal repair
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More than 30 million people in the US are eligible to have their arrest and conviction records cleared — but most people who qualify either can't afford it or simply don't know it's an option. In this gripping talk, second chance advocate and 2023 Audacious Project grantee Sheena Meade makes the case for "clean slate" laws that streamline this complicated process, increasing access to work, housi
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Industry says the Albanese government is ‘defunding space programs without explanation’ Follow our Australia news live blog for the latest updates Get our morning and afternoon news emails , free app or daily news podcast Australia’s first national space mission – building satellites to detect and respond to bushfires and floods, and to undertake maritime surveillance – is up in the air. The form
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Calcium homeostasis, involving the flow of calcium ions within cells, is essential for cell signaling and function. Importantly, calcium enters the cellular powerplants known as mitochondria, where it fine tunes energy production. Now, new research at the Lewis Katz School of Medicine at Temple University shows that, when it comes to mitochondria, calcium has another, vital function—serving as a r
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A new study published in PNAS Nexus explores the role of the dynamin protein DYN-1 in axonal fusion. The axon is a long, thin protrusion of nerve cells that carries electrical impulses. Severed axons can be repaired by a highly efficient regrowth process known as axonal fusion. Previous research has shown that molecules involved in apoptosis—programmed cell death—are also involved in axonal repair
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A team of ichthyologists from CSIRO National Research Collections Australia–Australian National Fish Collection, Hokkaido University and Sorbonne Université, EPHE has discovered a new species of deepwater shark after identifying egg cases found in a museum. In their study, reported in Journal of Fish Biology, the group found the shark after discovering unique shark egg cases in two Australian muse
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A team of ichthyologists from CSIRO National Research Collections Australia–Australian National Fish Collection, Hokkaido University and Sorbonne Université, EPHE has discovered a new species of deepwater shark after identifying egg cases found in a museum. In their study, reported in Journal of Fish Biology, the group found the shark after discovering unique shark egg cases in two Australian muse
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Authorities in eastern Switzerland ordered residents of the tiny village of Brienz to evacuate by Friday evening because geology experts say a mass of 2 million cubic meters of Alpine rock looming overhead could break loose and spill down in the coming weeks.
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An international collaboration of researchers, including the Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU) has succeeded in a proof-of-principle experiment to verify strong-field quantum electrodynamics with exotic atoms, by performing high-precision measurements of the energy spectrum of muonic characteristic X-rays emitted from muonic atoms using a state-of-the-art
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Our industrialized society releases many and various pollutants into the world. Combustion in particular produces aerosol mass including black carbon. Although this only accounts for a small percentage of aerosol particles, black carbon is especially problematic due to its ability to absorb heat and impede the heat reflection capabilities of surfaces such as snow. So, it's essential to know how bl
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Theories abound for why some people are mosquito magnets while others get off bite-free. A team of researchers from Virginia Tech report May 10 in the journal iScience that washing with some soaps attracted mosquitoes, while other soaps were repellent, but these effects varied between different people as a result of interactions between the soaps and each person's unique odor profile.
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Theories abound for why some people are mosquito magnets while others get off bite-free. A team of researchers from Virginia Tech report May 10 in the journal iScience that washing with some soaps attracted mosquitoes, while other soaps were repellent, but these effects varied between different people as a result of interactions between the soaps and each person's unique odor profile.
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The joke about the Human Genome Project is how many times it’s been finished, but not actually. The first time was in 2000, when Bill Clinton announced the “first survey of the entire human genome” at a White House ceremony, calling it “the most important and most wondrous map ever produced by humankind.” But the job wasn’t done. A year later, the triumph was announced again, this time with the f
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UC Santa Cruz scientists, along with a consortium of researchers, have released a draft of the first human pangenome—a new, usable reference for genomics that combines the genetic material of 47 individuals from different ancestral backgrounds to allow for a deeper, more accurate understanding of worldwide genomic diversity.
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Last month, Tesla CEO Elon Musk's lawyers argued that 2016 recordings of him making big promises about the car's Autopilot software could have been deepfaked. While the judge didn't buy the lawyers' arguments and ordered Musk to testify under oath, the stunt illustrates a broader trend. As generative AI-powered tools make it easier than ever before to synthesize the voices and faces of public fig
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A specialized weight loss program designed for Deaf people by Deaf people helped participants lose weight, researchers report. Losing weight can be hard for anyone, but may be especially difficult for Deaf sign language users who experience barriers to mainstream weight loss programs and the social support they offer. Over six months, Deaf sign language users who participated in the program lost
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Kenny, Josh, and Henry had to move their still site after someone posted a picture of it on social media. #discoveryplus #moonshiners Stream Full Episodes of Moonshiners https://www.discoveryplus.com/show/moonshiners About Moonshiners: Every spring, a fearless group of men and women venture deep into the woods of Appalachia, defying the law, rivals and nature itself to keep the centuries-old trad
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D oes climate change directly influence the weather we experience? Until recently—for the past 40 years or so—that question has followed nearly every major hurricane or flood, every record snowfall or heat wave. In some people, it provokes instant denial, often political or economic, often rooted in prideful ignorance. But the question raises a genuine analytical issue: How do we determine the ef
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Training Day OpenAI's finances are all over the place , but one thing is clear — not much of the money it spends or earns is going to the low-wage contract workers hired to train its AI. Two OpenAI contractors revealed to NBC News that the kind of work that goes into training large language models (LLMs) like those behind ChatGPT is very much "grunt work" — though in the case of these two individ
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The planet’s biomass—the material that makes up all living organisms—is concentrated in organisms at either end of the size spectrum, research finds. Researchers spent five years compiling and analyzing data about the size and biomass of every type of living organism on the planet—from tiny one-celled organisms like soil archaea and bacteria to large organisms like blue whales and sequoia trees.
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Nature Communications, Published online: 10 May 2023; doi:10.1038/s41467-023-38432-6 Malignant peripheral nerve sheath tumours are an aggressive form of sarcoma, with limited treatment options. Here, the authors utilise DNA methylation and transcriptomic data to identify two subtypes of tumours with potential therapeutic vulnerabilities.
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Residents were not at home in Hopewell Township when rock appeared to hit house on Monday A possible meteorite crashed into a bedroom of a New Jersey home, puncturing a hole into the roof and leaving residents rattled, though they were not home at the time. The metallic object in the Monday incident looks like a shiny rock, about 4in by 6in, police in Hopewell Township said. Continue reading…
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An unusual quasicrystal has been discovered by a team from the Martin Luther University Halle-Wittenberg (MLU), the University of Sheffield and Xi'an Jiaotong University. It has a dodecagonal honeycomb structure that has never been seen before. Until now, similar quasicrystals were only known to come in a solid—not liquid—form. The team presents its results in the journal Nature Chemistry.
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A new advanced artificial intelligence (AI) system has shown world-leading accuracy and speed in identifying protein patterns within individual cells. The new system, developed at the University of Surrey's Institute for People-Centered AI, could help scientists understand differences in cancer tumors and identify new drugs for diseases.
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In 2018, just as 3D printing was starting to take off as a construction method, Dubai set an ambitious goal: the city wanted to become the 3D printing capital of the world, aiming for a quarter of its new buildings to be printed rather than conventionally constructed. Follow-through was swift, with the Dubai municipality building becoming the world’s largest 3D-printed structure in 2019. The city
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The bodies of birds across the Americas are getting smaller and longer-winged as the world warms, according to new resarch. Smallest-bodied species are changing the fastest, the researchers report. The new study combines data from two previously published papers that measured body-size and wing-length changes in a total of more than 86,000 bird specimens over four decades in North and South Ameri
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Scientists at EPFL have developed PeSTo, an AI model that can predict, with high confidence, the binding interfaces of proteins when they bind other proteins, nucleic acids, lipids, ions, and small molecules. The model's low computational cost enables the processing of large amounts of structural data, opening up opportunities for new biological discoveries. The research is published in the journa
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Bacteria are intimately involved in our daily lives. These microorganisms have been used in human history for food such as cheese, yogurt, and wine. In more recent years, through metabolic engineering, microorganisms been used extensively as microbial cell factories to manufacture plastics, feed for livestock, dietary supplements and drugs.
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Om en främling rör vid oss strax innan vår partner rör oss – ja, då kan få vi få skralt påslag av må bra-hormonet oxytocin när partnern rör oss. Det framgår av en studie där personer smektes på armen. Det hela tros handla om ett system som är flexibelt för att passa oss människor i våra relationer. Inlägget dök först upp på forskning.se .
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The ASTRONET Science Vision and Infrastructure Roadmap 2022 to 2035 is the latest comprehensive roadmap produced by the ASTRONET network of European funding agencies and research organizations. The network includes the UK Science and Technology Facilities Council (STFC).
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In a development that could make quantum computers less prone to errors, a team of physicists from Quantinuum, California Institute of Technology and Harvard University has created a signature of non-Abelian anyons (nonabelions) in a special type of quantum computer. The team has published their results on the arXiv preprint server.
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Scientists at EPFL have developed PeSTo, an AI model that can predict, with high confidence, the binding interfaces of proteins when they bind other proteins, nucleic acids, lipids, ions, and small molecules. The model's low computational cost enables the processing of large amounts of structural data, opening up opportunities for new biological discoveries. The research is published in the journa
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Bacteria are intimately involved in our daily lives. These microorganisms have been used in human history for food such as cheese, yogurt, and wine. In more recent years, through metabolic engineering, microorganisms been used extensively as microbial cell factories to manufacture plastics, feed for livestock, dietary supplements and drugs.
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Anionic M0 complexes (M = group 10 metals) have attracted attention as active species for catalytic reactions; however, their molecular structures have very rarely been determined due to their extremely high reactivity. Particularly, the structures of Pt0 complexes, which are expected to exhibit a high degree of reactivity, have not been determined, and their syntheses have been almost nonexistent
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Each winter off the western tip of the Caribbean island of Little Cayman, thousands of endangered Nassau grouper gather to spawn under the light of the full moon. The fish pack the coral reef and when the ritual begins individual females dash out of the fray straight up towards the surface with multiple males in pursuit. During these vertical bursts, females release their eggs and the males jostle
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This is today’s edition of The Download , our weekday newsletter that provides a daily dose of what’s going on in the world of technology. This startup says its first fusion plant is five years away. Experts doubt it. The news : A startup called Helion, backed by Sam Altman, claims it’s on track to flip on the world’s first fusion power plant in five years. That’s a dramatically short timeline fo
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Each winter off the western tip of the Caribbean island of Little Cayman, thousands of endangered Nassau grouper gather to spawn under the light of the full moon. The fish pack the coral reef and when the ritual begins individual females dash out of the fray straight up towards the surface with multiple males in pursuit. During these vertical bursts, females release their eggs and the males jostle
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An international team of astronomers has used the James Webb Space Telescope (JWST) to observe a luminous dusty star-forming galaxy known as GN20. Results of the observational campaign, published April 26 on the arXiv preprint server, deliver important insights into the stellar structure of this galaxy.
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A startup backed by Sam Altman says it’s on track to flip on the world’s first fusion power plant in five years, dramatically shortening the timeline to a carbon-free energy source that’s eluded scientists for three-quarters of a century . Helion Energy’s announcement that it’s on the verge of commercializing the process that powers the sun is an astounding claim—and a questionable one, according
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