Artikler med Jørn Dyerberg som medforfatter. (Listen er fra Pubmed pr. 23. marts 2013).

1.
BMJ Open. 2012 Sep 17;2(5). pii: e000859. doi: 10.1136/bmjopen-2012-000859. Print 2012.=A trans European Union difference in the decline in trans fatty acids in popular foods: a market basket investigation.=
Stender S, Astrup A, Dyerberg J.===Source===
Department of Clinical Biochemistry, Copenhagen University Hospital, Gentofte, Denmark.

Abstract

OBJECTIVES:

To minimise the intake of industrial trans fatty acids (I-TFA) some countries have introduced labelling, while others have introduced legislative limits on the content of I-TFA in food. However, most countries still rely on food producers to voluntarily reduce the I-TFA content in food. The objective of the present study was to investigate the efficiency of these strategies in the EU.

DESIGN:

The potential consumption of I-TFA was assessed in a market basket investigation by analysing the I-TFA content in popular foods.

SETTING:

A standardised purchase methodology was used in 16 EU countries in 2005 and again in 2009.

SAMPLES:

Seventy servings of French fries and chicken nuggets, 90 packages of microwave popcorn, and 442 samples of biscuits/cakes/wafers with 'partially hydrogenated vegetable fat' listed high on the list of ingredients were analysed. A high-trans menu was defined as a large serving of French fries and nuggets, 100 g of microwave popcorn and 100 g of biscuits/wafers/cakes.

RESULTS:

In 2005, a high-trans menu provided above 30 g of I-TFA in five EU countries in Eastern Europe and 20-30 g in eight EU countries in Western Europe. In 2009 the values in Hungary, Poland and the Czech Republic remained high between 10 and 20 g, whereas they were less than 2 g in Germany, France and the UK.

CONCLUSIONS:

In 2009 contents of I-TFA in popular foods in Western Europe appear low but, in spite of some reduction, still high in Eastern European EU countries. These findings suggest that millions of people in the EU still consume I-TFA in amounts that substantially increase their risk of coronary heart disease.
PMID:22986123[PubMed] PMCID:PMC3467660 Free PMC ArticleRelated citations
Icon for HighWireIcon for PubMed Central

2.
Am J Clin Nutr. 2011 Apr;93(4):684-8. doi: 10.3945/ajcn.110.004622. Epub 2011 Jan 26.=The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?=
Astrup A, Dyerberg J, Elwood P, Hermansen K, Hu FB, Jakobsen MU, Kok FJ, Krauss RM, Lecerf JM, LeGrand P,Nestel P, Risérus U, Sanders T, Sinclair A, Stender S, Tholstrup T, Willett WC.===Source===
Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark.

Abstract

Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs are replaced with polyunsaturated fatty acids (PUFAs). In populations who consume a Western diet, the replacement of 1% of energy from SFAs with PUFAs lowers LDL cholesterol and is likely to produce a reduction in CHD incidence of ≥2-3%. No clear benefit of substituting carbohydrates for SFAs has been shown, although there might be a benefit if the carbohydrate is unrefined and has a low glycemic index. Insufficient evidence exists to judge the effect on CHD risk of replacing SFAs with MUFAs. No clear association between SFA intake relative to refined carbohydrates and the risk of insulin resistance and diabetes has been shown. The effect of diet on a single biomarker is insufficient evidence to assess CHD risk. The combination of multiple biomarkers and the use of clinical endpoints could help substantiate the effects on CHD. Furthermore, the effect of particular foods on CHD cannot be predicted solely by their content of total SFAs because individual SFAs may have different cardiovascular effects and major SFA food sources contain other constituents that could influence CHD risk. Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate alternatives.
PMID:21270379[PubMed – indexed for MEDLINE] PMCID:PMC3138219 Free PMC ArticleRelated citations
Icon for HighWireIcon for PubMed Central
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

3.
Nutr Diabetes. 2011 Jan 31;1:e4. doi: 10.1038/nutd.2010.4.=Effect of trans fatty acid intake on abdominal and liver fat deposition and blood lipids: a randomized trial in overweight postmenopausal women.=
Bendsen NT, Chabanova E, Thomsen HS, Larsen TM, Newman JW, Stender S, Dyerberg J, Haugaard SB, Astrup A.===Source===
Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark.

Abstract

Background:Intake of industrially produced trans fatty acids (TFAs) is, according to observational studies, associated with an increased risk of cardiovascular disease, but the causal mechanisms have not been fully elucidated. Besides inducing dyslipidemia, TFA intake is suspected to promote abdominal and liver fat deposition.Objective:We examined the effect of a high intake of TFA as part of an isocaloric diet on whole-body, abdominal and hepatic fat deposition, and blood lipids in postmenopausal women.Methods:In a 16-week double-blind parallel intervention study, 52 healthy overweight postmenopausal women were randomized to receive either partially hydrogenated soybean oil providing 15.7 g day(-1) of TFA or a control oil with mainly oleic and palmitic acid. Before and after the intervention, body composition was assessed by dual-energy X-ray absorptiometry, abdominal fat by magnetic resonance (MR) imaging, and liver fat by (1)H MR spectroscopy.Results:Compared with the control fat, TFA intake decreased plasma high-density lipoprotein (HDL)-cholesterol by 10%, increased low-density lipoprotein (LDL)-cholesterol by 18% and resulted in an increased LDL/HDL-cholesterol ratio (baseline adjusted mean (95% CI) difference between diet groups 0.41 (0.22; 0.60); P<0.001). TFA tended to increase the body fat (0.46 (-0.20; 1.17) kg; P=0.16) and waist circumference (1.1 (-0.1; 2.4) cm; P=0.08) more than the control fat, whereas neither abdominal nor liver fat deposition was affected by TFA.Conclusion:The adverse effect of dietary TFA on cardiovascular disease risk involves induction of dyslipidemia, and perhaps body fat, whereas weight gain-independent accumulation of ectopic fat could not be identified as a contributory factor during short-term intake.
PMID:23154296[PubMed] PMCID:PMC3302130 Free PMC ArticleRelated citations
Icon for PubMed Central

4.
Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):137-41. doi: 10.1016/j.plefa.2010.06.007.=Bioavailability of marine n-3 fatty acid formulations.=
Dyerberg J, Madsen P, Møller JM, Aardestrup I, Schmidt EB.===Source===
Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark. jdcon@post4.tele.dk

Abstract

The use of marine n-3 polyunsaturated fatty acids (n-3 PUFA) as supplements has prompted the development of concentrated formulations to overcome compliance problems. The present study compares three concentrated preparations – ethyl esters, free fatty acids and re-esterified triglycerides – with placebo oil in a double-blinded design, and with fish body oil and cod liver oil in single-blinded arms. Seventy-two volunteers were given approximately 3.3g of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) daily for 2 weeks. Increases in absolute amounts of EPA and DHA in fasting serum triglycerides, cholesterol esters and phospholipids were examined. Bioavailability of EPA+DHA from re-esterified triglycerides was superior (124%) compared with natural fish oil, whereas the bioavailability from ethyl esters was inferior (73%). Free fatty acid bioavailability (91%) did not differ significantly from natural triglycerides. The stereochemistry of fatty acid in acylglycerols did not influence the bioavailability of EPA and DHA.
Copyright 2010 Elsevier Ltd. All rights reserved.
PMID:20638827[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

5.
N Engl J Med. 2009 Jul 16;361(3):314-6. doi: 10.1056/NEJMc0903380.=What went in when trans went out?=
Stender S, Astrup A, Dyerberg J.PMID:19605843[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for Atypon
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

6.
Obes Rev. 2008 Mar;9 Suppl 1:48-52. doi: 10.1111/j.1467-789X.2007.00438.x.=Nutrition transition and its relationship to the development of obesity and related chronic diseases.=
Astrup A, Dyerberg J, Selleck M, Stender S.===Source===
Department of Human Nutrition, Centre for Advanced Food Studies, Faculty of Life Sciences, The University of Copenhagen, Frederiksberg, Denmark. ast@life.ku.dk

Abstract

The prevalence of overweight and obesity has also increased substantially in the nutritional transition countries, and the health burden of obesity-related complications is growing. The introduction of fast-food chains and Westernized dietary habits providing meals with fast-food characteristics seems to be a marker of the increasing prevalence of obesity. The mechanisms involved are probably that the supply of foods is characterized by large portion sizes with a high energy density, and sugar-rich soft drinks. The high energy density of foods is partly brought about by a high dietary fat content, and it has been shown that even in a Chinese population the increase from about 15% to 20% in the proportion of calories from fat is sufficient to explain some weight gain in the population. In addition, fast food from major chains in most countries still contains unacceptably high levels of industrially produced trans fatty acids that have powerful biological effects, and contribute to type 2 diabetes and coronary artery disease. New evidence also suggests that a high intake of trans fat may produce abdominal obesity, an important factor in the metabolic syndrome, type 2 diabetes and cardiovascular disease. The optimal diet for the prevention of weight gain, obesity, metabolic syndrome and type 2 diabetes is fat-reduced, without any industrially produced trans fatty acids, fibre-rich, high in low energy density carbohydrates (fruit, vegetables and whole grain products) and with a restricted intake of energy-containing drinks.
PMID:18307699[PubMed – indexed for MEDLINE] Related citations
Icon for Blackwell Publishing
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

7.
Int J Epidemiol. 2008 Feb;37(1):173-82. Epub 2007 Dec 12.=Intake of ruminant trans fatty acids and risk of coronary heart disease.=
Jakobsen MU, Overvad K, Dyerberg J, Heitmann BL.===Source===
Research Unit for Dietary Studies at Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Øster Søgade 18, DK-1357 Copenhagen, Denmark. muj@dce.au.dk

Abstract

BACKGROUND:

Studies have shown a positive association between trans fatty acids (TFA) intake and risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA. Some of these studies indicate an inverse association between ruminant TFA (R-TFA) intake and CHD implying that R-TFA intake is innocuous or even protective against CHD. The aim of this study was to describe the association between R-TFA intake and risk of CHD evaluating both the absolute and the energy-adjusted intake.

METHODS:

The study was an 18-year follow-up study of 3686 Danes, aged 30-71 years, at baseline without previous CHD.

RESULTS:

There were no overall associations between absolute or energy-adjusted R-TFA intakes and risk of CHD. However, among women, indications of inverse associations between R-TFA intake and risk of CHD were found: hazard ratio (HR) per 0.5 g increase in absolute R-TFA intake = 0.84 [95% confidence interval (CI): 0.70, 1.01] and HR per 0.5 g increase in energy-adjusted R-TFA intake = 0.77 (95% CI: 0.55, 1.09). No associations between absolute or energy-adjusted R-TFA intakes and CHD were found among men.

CONCLUSIONS:

This study suggests that R-TFA intake is not associated with a higher risk of CHD. Whether R-TFA intake is even protective against CHD among women cannot be concluded from this study.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlCommentary: Ruminant trans fatty acids and coronary heart disease–cause for concern? [Int J Epidemiol. 2008]

PMID:18077475[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

8.
Food Nutr Res. 2008;52. doi: 10.3402/fnr.v52i0.1651. Epub 2008 Mar 12.=Ruminant and industrially produced trans fatty acids: health aspects.=
Stender S, Astrup A, Dyerberg J.===Source===
Department of Clinical Biochemistry, Gentofte University Hospital, Denmark.

Abstract

Fatty acids of trans configuration in our food come from two different sources – industrially produced partially hydrogenated fat (IP-TFA) used in frying oils, margarines, spreads, and in bakery products, and ruminant fat in dairy and meat products (RP-TFA). The first source may contain up to 60% of the fatty acids in trans form compared to the content in ruminant fat which generally does not exceed 6%. In Western Europe, including Scandinavia, the average daily intake of IP-TFA has decreased during the recent decade due to societal pressure and a legislative ban, whereas the intake of RP-TFA has remained stable.In spite of this decrease we have found that in many countries consumption >20 g of IP-TFA in a one-meal menu consisting of some popular foods is possible, even though the average intake of IP-TFA in these countries is low. Subgroups of the populations may therefore, on average, consume >5 g IP-TFA per day. This level of consumption is generally not possible for RP-TFA. A daily intake of 5 g TFA (primarily IP-TFA) is associated with a 29% increased risk of coronary heart disease. Such an association is not found for RP-TFA up to a daily intake of 4 g.The high amount of IP-TFA in popular foods, the evidence of a more harmful effect on health by IP-TFA than by RP-TFA, and the feasibility of eliminating IP-TFA from foods without side effects for the population, suggest that a selective elimination of IP-TFA from our food is a 'low hanging fruit' in the quest for a more healthy diet for subgroups of the population.
PMID:19109659[PubMed] PMCID:PMC2596737 Free PMC ArticleRelated citations
Icon for PubMed Central

9.
Sci Total Environ. 2007 Oct 1;384(1-3):106-19. Epub 2007 Jul 16.=Traditional and modern Greenlandic food – dietary composition, nutrients and contaminants.=
Deutch B, Dyerberg J, Pedersen HS, Aschlund E, Hansen JC.===Source===
Centre for Arctic Environmental Medicine, Aarhus University, Building 260, Vennelyst Boulevard 6, DK-8000, Aarhus, Denmark. bd@mil.au.dk

Abstract

OBJECTIVES:

High levels of n-3 fatty acids and other nutrients in traditional Inuit food appear to provide some protection against the typical diseases of affluent industrialized societies: cardiovascular diseases and type 2 diabetes. An increased intake of imported food among Inuits will probably increase their frequency of these diseases. However, since the 1970s it has become evident that the marine-based Inuit diet also contains high levels of potentially toxic lipophilic organic pollutants and heavy metals. Since these two food related opposing health effects appear to be inseparable, the phenomenon has been known as "The Arctic Dilemma". However, both the fatty acid composition and the contaminant levels vary in Greenlandic food items. Thus in principle it is possible to compose a diet where the benefits and risks are better balanced. Our objectives of this study were to compare traditional and modern meals in Greenland concerning the dietary composition, nutrients, and health indicators among the consumers.

STUDY DESIGN:

The present study was a cross-sectional dietary survey as part of the Arctic Monitoring and Assessment, Human Health Programme (AMAP). These results were compared with older dietary surveys in Greenland.

METHODS:

Dietary components, fatty acids, and nutrients in 90 local meals collected by duplicate portion method in Uummannaq town, north Greenland 2004 and in Narsaq, south Greenland 2006, were compared with 177 duplicate meals sampled in the village of Igdslorsuit, Uummannaq, district, 1976 and also compared with other dietary studies in Greenland 1953-1987. Anthropometric measures (weight, height, and body mass index, BMI) and blood lipids were measured as health indicators among the participants.

RESULTS:

Between the traditional foods sampled or analysed 30-50 years ago and the modern food from 2004 to 2006, significant differences were found in the dietary composition. The percentage of local food had decreased, to a present average of about 20% and with it the dietary content of n-3 fatty acids. Also, the intakes of many vitamins and minerals had decreased, and were below Nordic Nutrient Recommendations in 2004 and 2006. Vitamin A, B(1), (B(2)), B(12), iron, iodine, phosphorus, and selenium contents were correlated with n-3 content, whereas vitamin C, folate, and calcium contents were not and the same time very low. In the traditional food, especially from the villages, the intakes of vitamin A, vitamin D, and iron were extremely high and borderline toxic. The levels of contaminants such as organochlorins and heavy metals were also strongly correlated with the relative content of local food in the diet. The best balance between potentially beneficial and harmful substances was found for 20-30% local food, corresponding to a daily intake of 3-5 g of n-3 fatty acids. Body weight, height, body mass index (BMI), cholesterol, and S-triglycerides had increased significantly between 1976 and 2004.

CONCLUSION:

The dietary changes to a more western fare were found to be negative resulting in less adequate nutrient coverage but at the same time lower contaminant load. Thus, we recommend not to increase the consumption of local products beyond the present level but rather to improve the quality of the imported food.
PMID:17629548[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

10.
Int J Obes (Lond). 2007 Jun;31(6):887-90. Epub 2007 Apr 24.=Fast food: unfriendly and unhealthy.=
Stender S, Dyerberg J, Astrup A.===Source===
Department of Clinical Biochemistry, Gentofte Hospital University of Copenhagen, Copenhagen, Denmark.

Abstract

Although nutrition experts might be able to navigate the menus of fast-food restaurant chains, and based on the nutritional information, compose apparently 'healthy' meals, there are still many reasons why frequent fast-food consumption at most chains is unhealthy and contributes to weight gain, obesity, type 2 diabetes and coronary artery disease. Fast food generally has a high-energy density, which, together with large portion sizes, induces over consumption of calories. In addition, we have found it to be a myth that the typical fast-food meal is the same worldwide. Chemical analyses of 74 samples of fast-food menus consisting of French fries and fried chicken (nuggets/hot wings) bought in McDonalds and KFC outlets in 35 countries in 2005-2006 showed that the total fat content of the same menu varies from 41 to 65 g at McDonalds and from 42 to 74 g at KFC. In addition, fast food from major chains in most countries still contains unacceptably high levels of industrially produced trans-fatty acids (IP-TFA). IP-TFA have powerful biological effects and may contribute to increased weight gain, abdominal obesity, type 2 diabetes and coronary artery disease. The food quality and portion size need to be improved before it is safe to eat frequently at most fast-food chains.

Comment on

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlFast food: friendly? [Int J Obes (Lond). 2007]

Republished in

• Ugeskr Laeger. 2007 May 7;169(19):1804-6.

PMID:17452996[PubMed – indexed for MEDLINE] Related citations
Icon for Nature Publishing Group
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

11.
Ugeskr Laeger. 2007 May 7;169(19):1804-6.=[Fast food promotes weight gain].=
[Article in Danish]
Stender S, Dyerberg J, Astrup AV.===Source===
Gentofte Hospital, Klinisk-biokemisk Afdeling, Hellerup. stst@geh.regionh.dk

Abstract

The total amounts of fat in a fast food menu consisting of French fries and fried Chicken Nuggets from McDonald's and KFC, respectively, bought in 35 different countries vary from 41 to 71 gram. In most countries the menu contained unacceptably high amounts of industrially-produced trans fat which contributes to an increased risk of ischaemic heart disease, weight gain, abdominal fat accumulation and type 2 diabetes. The quality of the ingredients in fast food ought to be better and the size of the portions smaller and less energy-dense so that frequent fast food meals do not increase the risk of obesity and diseases among customers.

Republished from

• Int J Obes (Lond). 2007 Jun;31(6):887-90.

PMID:17537359[PubMed] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types===

12.
Lakartidningen. 2007 Feb 28-Mar 6;104(9):691; author reply 691.=[Trans fats–good if Sweden could follow the Danish example].=
[Article in Swedish]
Dyerberg J, Stender S, Astrup A.PMID:17393870[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

13.
Sci Total Environ. 2006 Nov 1;370(2-3):372-81. Epub 2006 Aug 14.=Dietary composition and contaminants in north Greenland, in the 1970s and 2004.=
Deutch B, Dyerberg J, Pedersen HS, Asmund G, Møller P, Hansen JC.===Source===
Centre for Arctic Environmental Medicine, Aarhus University, Vennelyst Boulevard 6, DK-8000, Aarhus, Denmark. bd@mil.au.dk

Abstract

OBJECTIVES:

The fatty acid composition and other nutrients in traditional Inuit food appear to provide some protection against diseases of affluent industrialized societies, such as cardiovascular diseases and type 2 diabetes. A transition towards increased amounts of imported food might increase the occurrence of these diseases among Inuit. However, since the 1970s it has become evident that the marine-based Inuit diet also contains high levels of potentially toxic lipophilic organic pollutants and heavy metals. Since these two opposing effects on health appear to be inseparable, the phenomenon has become known as "The Arctic Dilemma". However, both the fatty acid composition and the contaminant levels vary in Greenlandic food items. Thus, in theory, it is possible to compose a diet where the benefits outweigh the risks. Our objective was to compare traditional and modern meals in Greenland regarding dietary composition, content of n-3 fatty acids and contaminants.

STUDY DESIGN:

The present study was part of the Arctic Monitoring and Assessment Programme, AMAP, comparing the results of dietary composition and nutrients in 177 traditional meals collected in Uummannaq municipality, north Greenland in 1976 with 90 meals sampled in Uummannaq town in 2004 under similar conditions. Eleven pesticides, 14 PCB congeners, heavy metals, selenium, and fatty acids were analysed in meals and blood samples from the participants. Contaminant levels were compared between 1976 and 2004 after adjustment for n-3 fatty acids, indicating local food content.

RESULTS:

Between the traditional meals collected 30 years ago and the meals from 2004, dramatic and significant changes have occurred in the dietary composition. The percentage of local food has decreased, and with it the intake of n-3 fatty acids. Calculated as daily intake, all but three contaminants had decreased significantly. However, this could be explained by the lower intake of local food. After adjustment for n-3 fatty acid content in the food, significant declines of concentration in the local food were evident only for PCBs and lead, whereas for mercury, DDTs, and chlordanes the levels were unchanged, and for hexachlorobenzene, mirex, and toxaphenes, the levels had increased significantly.

CONCLUSION:

The consumption of locally produced food has decreased in Greenland during the last 30 years and this has led to a reduction in the daily intake of contaminants. However, the concentrations of contaminants in local food items have not decreased, except for PCB and Lead. Therefore, we recommend that the consumption of local products is not increased beyond the present level, until the level of contaminants is reduced to a safer level.
PMID:16904734[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

14.
Ugeskr Laeger. 2006 Aug 21;168(34):2787-9.=[Antioxidants and health].=
[Article in Danish]
Skibsted LH, Dragsted LO, Dyerberg J, Hansen HS, Kiens B, Ovesen LF, Tjønneland AM.===Source===
Motions- og Ernaeringsrådets, Søborg. sm@meraadet.dk

Abstract

The Danish Fitness and Nutrition Council has evaluated the basis for recommendations on the intake of antioxidants and has found limited basis for increasing the recommended intake levels for the antioxidants vitamin C and E. Evidence was insufficient to support recommendations for polyphenol or carotenoid supplementation. Supplementation with high doses of vitamin E and beta-carotene may present a health risk. A high intake of fruit and vegetables is associated with a reduced risk of lifestyle diseases, but there is no evidence that this association is due to an antioxidant effect.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface control[Antioxidants and AMD]. [Ugeskr Laeger. 2006]

PMID:16942696[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

15.
Atheroscler Suppl. 2006 May;7(2):33-5. Epub 2006 May 18.=Trans, and n-3 polyunsaturated fatty acids and vascular function-a yin yang situation?=
Dyerberg J, Christensen JH, Eskesen D, Astrup A, Stender S.===Source===
Capio Diagnostics Ltd., Copenhagen, Denmark. jdcon@post4.tele.dk

Abstract

Trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (n-3 PUFA) have opposite effects on several biological functions. We report a study on the effects on risk markers for cardiovascular disease. Eighty-seven healthy males were randomly assigned to 8 weeks of daily intake of either 20 g of industrially produced TFA (IP-TFA), 4 g n-3 PUFA, or control fat, incorporated in bakery products as part of the daily food. High-density lipoprotein cholesterol decreased in the TFA-group, triglycerides and mean arterial blood pressure decreased in the n-3 group. Heart rate variability (HRV), arterial dilatory capacity, flow mediated vasodilation, compliance, and distensibility were unchanged. Post hoc, we did a subgroup analysis of the results from the subjects with normal initial HRV. In these, 24-h heart rate (HR) was significantly increased by approximately three beats/min in the TFA group, with a decrease of the same magnitude in the n-3 group. A high HR is associated to an increased mortality and vice versa. Our results thus support the notion that IP-TFA and n-3 PUFA affect risk for cardiovascular mortality via mechanisms not only related to changes in plasma concentrations of lipids and lipoproteins.
PMID:16713391[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

16.
Atheroscler Suppl. 2006 May;7(2):9-11. Epub 2006 May 18.=Intake of ruminant trans fatty acids and risk of coronary heart disease-an overview.=
Jakobsen MU, Bysted A, Andersen NL, Heitmann BL, Hartkopp HB, Leth T, Overvad K, Dyerberg J.===Source===
Research Unit for Dietary Studies and Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen University Hospital, Denmark. mu@ipm.hosp.dk

Abstract

Epidemiological studies have shown a strong direct (positive) association between the intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), primarily accounted for by industrially produced TFA (IP-TFA). However, comparisons between ruminant TFA (R-TFA) and IP-TFA and risk of CHD have been based on quintiles of intake, which implies that the associations between the two sources of TFA and the risk of CHD were described across different ranges of intake. Controlled metabolic studies of the effect of intake of total and specific R-TFA on CHD risk factors are warranted. Moreover, further epidemiological studies of intake of R-TFA and risk of CHD in populations with a high intake of R-TFA are warranted.
PMID:16713389[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

17.
Atheroscler Suppl. 2006 May;7(2):47-52. Epub 2006 May 19.=A trans world journey.=
Stender S, Dyerberg J, Bysted A, Leth T, Astrup A.===Source===
Department of Clinical Biochemistry, Gentofte University Hospital, Copenhagen, Denmark. stst@gentoftehosp.kbhamt.dk

Abstract

A high intake of industrially produced trans fatty acids (IP-TFA) is associated with increased risk of coronary heart disease (CHD), and a daily intake as low as possible is required to minimize health risks. To achieve this at the individual level in Denmark, legislation limited IP-TFA in foods to a maximum of 2% of fat content from 2004. We assessed the potential exposure of consumers to IP-TFA by analysing popular foods in Denmark, and in 25 other countries. Fifty-five servings of French fries and chicken nuggets, 87 packages of microwave popcorn, and 393 samples of biscuits/cakes/wafers with "partially hydrogenated vegetable fat" listed high on the food label were bought between November 2004 and February 2006. The content of IP-TFA was analysed by standardized methodology. We defined a "high trans menu" as a large size serving of French fries and nuggets, 100 g of microwave popcorn, and 100 g of biscuits/wafers/cakes. The amounts of IP-TFA in a "high trans menu" was 30 g in 2001 in Denmark, but was reduced to less than 1g in 2005. By contrast, a "high trans menu" provided more than 20 g in 17 out of 18 countries, with Hungary, Czech Republic, Poland, Bulgaria, and USA, ranking highest with 42, 40, 38, 37, and 36 g, respectively. The legislation in Denmark has reduced the exposure of IP-TFA at the individual level without noticeable effect on availability, price, and quality of foods previously containing high amounts of IP-TFA. The findings of high concentrations of IP-TFA in popular foods outside Denmark suggest that millions of people inside and outside EU have intakes of IP-TFA that may increase their risk of CHD. The Danish experience demonstrates that this risk can be eliminated.
PMID:16713385[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

18.
Ugeskr Laeger. 2006 Apr 24;168(17):1654-7.=[High levels of industrially produced trans fatty acids in popular fast food – but not in Denmark–secondary publication].=
[Article in Danish]
Stender S, Dyerberg J, Bysted A, Leth T, Astrup AV.===Source===
Amtssygehuset i Gentofte, Klinisk-biokemisk Afdeling, Hellerup. stst@gentoftehosp.kbhamt.dk

Abstract

An intake of trans-fatty acids of 5 grams per day is associated with an increase of 25% in the risk of ischemic heart disease. In 2004 Denmark, as the first country in the world, introduced a limitation on the content of industrially produced trans-fatty acids in foods. The amount in a "high-trans menu" consisting of popular foods was, from 2001 to 2005, reduced in Denmark from 30 g to <1 g. The amount in the same menu bought in countries within and outside the European Union is 20-40 g. During a period of just a few years, Denmark has thus eliminated a risk factor for ischemic heart disease without noticeable side effects for consumers. This risk factor is, however, still present in many other countries.
PMID:16674878[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

19.
N Engl J Med. 2006 Apr 13;354(15):1650-2.=High levels of industrially produced trans fat in popular fast foods.=
Stender S, Dyerberg J, Astrup A.PMID:16611965[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for Atypon
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

20.
Eur J Clin Nutr. 2006 Mar;60(3):312-8.=Intake of ruminant trans fatty acids in the Danish population aged 1-80 years.=
Jakobsen MU, Bysted A, Andersen NL, Heitmann BL, Hartkopp HB, Leth T, Overvad K, Dyerberg J.===Source===
Research Unit for Dietary Studies and Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark. mu@ipm.hosp.dk

Abstract

OBJECTIVE:

To estimate the intake of ruminant trans fatty acids (TFA) in the Danish population aged 1-80 years.

DESIGN:

Descriptive study.

SUBJECTS:

A sex- and age-stratified random sample drawn from the Danish Civil Registration System. A total of 3098 participants (51% female) aged 1-80 years were included. The participation was 66%. DIETARY INFORMATION: A 7-day dietary record.

RESULTS:

The estimated median intake of ruminant TFA was 1.4 g/day with the 80% central range being from 0.9 to 2.1 among children aged 1-6 years and 1.6 g/day (1.0-2.4) among children aged 7-14 years. The median TFA intake was 1.8 g/day (0.9-2.9) among adults aged 15-29 years and among adults aged 30-80 years. The intake expressed as percentage of energy intake was 0.8, 0.6, 0.7, and 0.7, respectively. Dairy products were the main source of ruminant TFA.

CONCLUSIONS:

The median intake of ruminant TFA in the Danish population aged 1-80 years is estimated to be 1.7 g/day (0.9-2.7), corresponding to 0.7% of energy intake (0.5-1.0), with dairy products being the main source of ruminant TFA.

SPONSORSHIP:

The Danish Heart Foundation (Grants 02-2-9-8-22010 and 03-2-9-4-22087) and the Female Researchers in Joint Action (FREJA) programme from the Danish Medical Research Council.
PMID:16234830[PubMed – indexed for MEDLINE] Related citations
Icon for Nature Publishing Group
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

21.
Clin Chem. 2005 Aug;51(8):1457-61. Epub 2005 Jun 16.=Quantification of lipoprotein subclasses by proton nuclear magnetic resonance-based partial least-squares regression models.=
Petersen M, Dyrby M, Toubro S, Engelsen SB, Nørgaard L, Pedersen HT, Dyerberg J.===Source===
Institute of Human Nutrition, Department of Food Science, Quality and Technology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. mpe@kvl.de

Abstract

BACKGROUND:

Cardiovascular disease risk can be estimated in part on the basis of the plasma lipoprotein profile. Analysis of lipoprotein subclasses improves the risk evaluation, but the traditional methods are very time-consuming. Novel, rapid, and productive methods are therefore needed.

METHODS:

We obtained plasma samples from 103 fasting people and determined the plasma lipoprotein subclass profiles by an established ultracentrifugation-based method. Proton nuclear magnetic resonance (NMR) spectra were obtained from replicate samples on a 600 MHz NMR spectrometer. From the ultracentrifugation-based reference data and the NMR spectra, we developed partial least-squares (PLS) regression models to predict cholesterol and triglyceride (TG) concentrations in plasma as well as in VLDL, intermediate-density lipoprotein (IDL), LDL, 3 LDL fractions, HDL, and 3 HDL subclasses.

RESULTS:

The correlation coefficients (r) between the plasma TG and cholesterol concentrations measured by the 2 methods were 0.98 and 0.91, respectively. For LDL- and HDL-cholesterol concentrations, r = 0.90 and 0.94, respectively. For cholesterol concentrations in the LDL-1, LDL-2, and LDL-3 fractions, r = 0.74, 0.78, and 0.69, respectively, and for HDL subclasses HDL(2b), HDL(2a), and HDL(3), cholesterol concentrations were predicted with r = 0.92, 0.94, and 0.75, respectively. TG concentrations in VLDL, IDL, LDL, and HDL were predicted with correlations of 0.98, 0.85, 0.77, and 0.74, respectively. The cholesterol and TG concentrations in the main lipoprotein fractions and in LDL fractions and HDL subclasses predicted by the PLS models were 94%-100% of the concentrations obtained by ultracentrifugation.

CONCLUSION:

NMR-based PLS regression models are appropriate for use in research in which analyses of the plasma lipoprotein profile, including LDL and HDL subclasses, are required in large numbers of samples.
PMID:15961551[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

22.
Platelets. 2005 Aug;16(5):301-5.=No effect of taurine on platelet aggregation in men with a predisposition to type 2 diabetes mellitus.=
Spohr C, Brøns C, Winther K, Dyerberg J, Vaag A.===Source===
Steno Diabetes Center, Gentofte, Denmark. spohr@sol.dk

Abstract

Any diet therapy that potentially could affect platelet function would also influence the initiation of atherosclerotic plaque formation which is an important complication of diabetes mellitus eventually resulting in myocardial infarction and stroke. Blood platelets are rich in taurine, and it has been shown that taurine inhibits platelet aggregation in healthy subjects. The purpose was to examine the effect of taurine supplementation on platelet aggregation in high-risk subjects with a positive family history of T2DM. Twenty healthy men were included in a double-blinded, randomized, crossover study, receiving daily supplementation of 1.5 g taurine or placebo for two 8-week periods. Subjects were overweight and first-degree relatives of T2DM patients. At the end of each treatment, fasting blood samples for assessment of platelet aggregation was drawn. Platelet aggregation was induced by ADP. Plasma taurine concentration was significantly greater after taurine intervention compared to placebo (131.4+/-61.7 vs. 38.9+/-6.7 micromol/l, P<0.0001). There was no difference in the threshold level for complete platelet aggregation induced by ADP in vivo between placebo and taurine intervention (placebo 3.86+/-2.21 vs. taurine 3.86+/-3.25 micromol/l). Supplementation with 1.5 g of taurine for 8 weeks had no effect on platelet aggregation in overweight prediabetic men.
PMID:16011981[PubMed – indexed for MEDLINE] Related citations
Icon for Informa Healthcare
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

23.
Ugeskr Laeger. 2005 May 2;167(18):1971-2.=[N-3 polyunsaturated acids and cardiovascular disease. Cochrane analysis with unclear conclusions].=
[Article in Danish]
Dyerberg J, Astrup A, Stender S.===Source===
Den Kgl. Veterinaer- og Landbohøjskole, Institut for Human Ernaering, Capio Diagnostik a.s., og Amtssygehuset i Gentofte, Klinisk Biokemisk Afdeling.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface control[Do fish and omega-3 fatty acid prevent heart disease?]. [Ugeskr Laeger. 2005]

PMID:15929276[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

24.
Eur J Clin Nutr. 2004 Sep;58(9):1239-47.=Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic predisposition for type II diabetes mellitus.=
Brøns C, Spohr C, Storgaard H, Dyerberg J, Vaag A.===Source===
Steno Diabetes Center, Gentofte, Denmark. chbe@steno.dk

Abstract

BACKGROUND:

The prevalence of type 2 diabetes mellitus (T2DM) is increasing with an epidemic growth rate. Animal studies with taurine supplementation have shown increased insulin secretion and action, suggesting that taurine supplementation may have a potential to prevent T2DM.

OBJECTIVE:

To assess the effect of taurine treatment on insulin secretion and action, and on plasma lipid levels in overweight men with a positive history of T2DM.

DESIGN:

20 nondiabetic subjects were included in a double-blinded, randomized, crossover study, receiving a daily supplementation of 1.5 g taurine or placebo for two periods of 8 weeks. The subjects were overweight first-degree relatives of T2DM patients. An intravenous glucose tolerance test (IVGTT) was used to measure first-phase insulin secretory response, and a euglycemic hyperinsulinemic clamp was used to determine peripheral insulin action.

RESULTS:

Mean plasma taurine concentration was 39 +/- 7 (s.d.) micromol/l after placebo and 131 +/- 62 micromol/l after taurine intervention (P < 0.0001). There was no significant difference after taurine intervention compared to placebo in incremental insulin response (Insincr.) neither during the IVGTT, nor in insulin-stimulated glucose disposal during the clamp. Insulin secretion, adjusted for insulin sensitivity, was also unchanged. There was no significant effect of taurine supplementation on blood lipid levels as well.

CONCLUSION:

Daily supplementation with 1.5 g taurine for 8 weeks had no effect on insulin secretion or sensitivity, or on blood lipid levels. These findings in persons with an increased risk of T2DM are in contrast to those from animal studies, and do not support the assumption that dietary supplementation with taurine can be used to prevent the development of T2DM.
Copyright 2004 Nature Publishing Group
PMID:15054439[PubMed – indexed for MEDLINE] Related citations
Icon for Nature Publishing Group
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

25.
Am J Epidemiol. 2004 Jul 15;160(2):141-9.=Dietary fat and risk of coronary heart disease: possible effect modification by gender and age.=
Jakobsen MU, Overvad K, Dyerberg J, Schroll M, Heitmann BL.===Source===
Research Unit for Dietary Studies and Danish Epidemiology Science Centre, Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark. mu@ipm.hosp.dk

Abstract

In a 16-year follow-up study (ending in 1998) of 3,686 Danish men and women aged 30-71 years at recruitment, the association between energy intake from dietary fat and the risk of coronary heart disease was evaluated while assessing the possible modifying role of gender and age. In the models used, total energy and protein intake were fixed. Differences in intake of energy from fat thus reflected complementary differences in intake of energy from carbohydrates. A 5% higher level of energy from saturated fat intake was associated with a 36% greater risk of coronary heart disease among women (hazard ratio (HR) = 1.36, 95% confidence interval (CI): 0.98, 1.88). No overall association between saturated fat and coronary heart disease was found among men. However, age-dependent analyses showed that saturated fat was positively associated with coronary heart disease among the younger men (HR = 1.29, 95% CI: 0.87, 1.91) and the younger women (HR = 2.68, 95% CI: 1.40, 5.12) but not among the older men (HR = 0.94, 95% CI: 0.70, 1.28) and the older women (HR = 1.22, 95% CI: 0.86, 1.71). Polyunsaturated fat was inversely associated with coronary heart disease among women and men, although not significantly. In conclusion, the present study suggests that coronary heart disease risk relates to both the quantity and the quality of dietary fats.
PMID:15234935[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

26.
Eur J Clin Nutr. 2004 Jul;58(7):1062-70.=Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study.=
Dyerberg J, Eskesen DC, Andersen PW, Astrup A, Buemann B, Christensen JH, Clausen P, Rasmussen BF,Schmidt EB, Tholstrup T, Toft E, Toubro S, Stender S.===Source===
Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. jdcon@post4.tele.dk

Abstract

BACKGROUND:

Studies of long-term intake of industrially produced trans fatty acids (TFA) and n-3 polyunsaturated fatty acids (PUFA) suggest opposite effects on cardiovascular disease risk. Common mechanisms of action are probable.

OBJECTIVE:

To examine the effects on cardiovascular risk markers of dietary enrichment with TFA or n-3 PUFA.

DESIGN:

Randomized, double-blind, parallel intervention trial.

SETTING:

Department of Human Nutrition, The Royal Veterinary and Agricultural University.

SUBJECTS:

In all, 87 healthy males included, 79 completed.

INTERVENTION:

Subjects were randomly assigned to 8 weeks of a daily intake of 33 g of experimental fats from either partially hydrogenated soy oil containing 20 g of TFA, 12 g of fish oil with approximately 4 g of n-3 PUFA and 21 g of control fat, or 33 g of control fat. The experimental fats were incorporated into bakery products. Plasma lipids, blood pressure, heart rate variability (HRV), arterial dilatory capacity, compliance, and distensibility were recorded before and after intervention and at follow-up 12 weeks after the intervention.

RESULTS:

High-density lipoprotein cholesterol (HDL-C) decreased in the TFA group and triglycerides and mean arterial blood pressure decreased in the n-3 PUFA group compared to the control group. HRV, arterial dilatory capacity, compliance, and distensibility were unchanged.

CONCLUSION:

The results indicate that the association between coronary heart disease risk and intake of TFA and n-3 PUFA relates only modestly to changes in traditional risk markers.

SPONSORSHIP:

Danish Medical Research Council (Grant no. 22-01-0390), Center of Advanced Food Research (Copenhagen, Denmark) (Grant no. KVL-R-2001-107), the Danish Heart Association (Grant no. 99-2-3-45-22748), Novozymes (Bagsvaerd, Denmark), Aarhus Olie (Aarhus, Denmark), and from private sources. The experimental fats were provided by Pronova Biocare (Aalesund, Norway) and Aarhus Olie (Aarhus, Denmark).
PMID:15220949[PubMed – indexed for MEDLINE] Related citations
Icon for Nature Publishing Group
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

27.
Ugeskr Laeger. 2004 Jan 26;166(5):362-6.=[Hereditary angioedema].=
[Article in Danish]
Bygum A, Zachariae H, Dyerberg J, Kragballe K.===Source===
bygum@dadlnet.dk
PMID:15017729[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

28.
Ugeskr Laeger. 2004 Jan 5;166(1-2):29-32.=[Denmark is the first county in the world to forbid the use of industrially produced fatty acids].=
[Article in Danish]
Stender S, Dyerberg J.===Source===
Klinisk-biokemisk Afdeling, Amtssygehuset i Gentofte, DK-2900 Hellerup. stst@gentoftehosp.kbhamt.dk
PMID:14752989[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

29.
Ann Nutr Metab. 2004;48(2):61-6. Epub 2003 Dec 16.=Influence of trans fatty acids on health.=
Stender S, Dyerberg J.===Source===
Danish Nutrition Council, Gentofte Hospital, University of Copenhagen, Denmark. stst@gentoftehosp.kbhamt.dk

Abstract

The contribution of dietary trans fatty acids (TFAs) on the risk of ischemic heart disease (IHD) has recently gained further support due to the results from large, prospective, population-based studies. Compared to saturated fat, TFAs are, gram to gram, associated with a considerably (2.5- to >10-fold) higher risk increment for IHD. A negative effect on the human fetus and on newborns and an increase in colon cancer risk in adults are possible but, however, still equivocal. Recent findings justify further studies concerning the effect of TFAs on allergic diseases in children and on the risk of type-2 diabetes in adults. The intake of industrially produced TFAs in European countries is decreasing. However, determination of the TFA content in various popular food items collected in Danish shops showed that it is likely that persons with a frequent intake of, e.g., French fries, microwave oven popcorn, chocolate bars, fast food, etc., consume industrially produced TFAs in amounts far exceeding the average intake, and are thereby exposed to an unnecessary health risk. The Danish government has decided that oils and fats containing more than 2% industrially produced TFAs will not be sold in Denmark after the January 1, 2004.
Copyright 2004 S. Karger AG, Basel
PMID:14679314[PubMed – indexed for MEDLINE] Related citations
Icon for S. Karger AG, Basel, Switzerland
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

30.
Eur J Intern Med. 2003 Jul;14(4):244-248.=Plasma homocysteine, angiographically proven coronary artery disease, and wine consumption.=
Toft E, Ellegaard Hansen V, Hagstrup Christensen J, Berg Schmidt E, Aarup Skou H, Fog L, Ekelund S, Dyerberg J.===Source===
Department of Cardiology, Aalborg Hospital, Arhus University Hospital, Aalborg, Denmark

Abstract

BACKGROUND:

Plasma total homocysteine (p-tHcy) is considered to be an independent risk factor for atherosclerotic vascular disease. This cross-sectional study was undertaken to examine p-tHcy levels and their relationship to coronary artery disease (CAD) and alcohol intake.

METHODS:

We consecutively studied 291 patients referred for elective coronary angiography due to suspected CAD. The patients completed an alcohol questionnaire, and blood samples were drawn after an overnight fast for measurement of p-tHcy.

RESULTS:

Patients without CAD (n=85) had significantly lower p-tHcy (10.1+/-4.7 μmol/l) than patients with at least one significant coronary artery stenosis (n=206, p-tHcy: 11.9+/-6.4 μmol/l). Patients with a previous myocardial infarction (MI; n=74) also had a higher p-tHcy (12.3+/-4.0 μmol/l) than patients without MI (n=217; p-tHcy: 10.7+/-6.2 μmol/l). Patients with a daily intake of wine (n=30) had lower p-tHcy (9.4+/-2.8 μmol/l) than patients who did not drink wine (n=47; p-tHcy: 12.1+/-6.0 μmol/l; P<0.05), independent of age, prior MI, and degree of CAD.

CONCLUSIONS:

p-tHcy correlated positively with CAD. There was an inverse correlation between p-tHcy and wine consumption, suggesting a new potential mechanism by which wine consumption may lower the risk of CAD.
PMID:12919840[PubMed – as supplied by publisher] Related citations
Icon for Elsevier Science

31.
Am J Clin Nutr. 2002 Dec;76(6):1202-6.=Effect of protein and methionine intakes on plasma homocysteine concentrations: a 6-mo randomized controlled trial in overweight subjects.=
Haulrik N, Toubro S, Dyerberg J, Stender S, Skov AR, Astrup A.===Source===
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Copenhagen.

Abstract

BACKGROUND:

A high plasma homocysteine concentration is an independent risk factor for cardiovascular disease. Homocysteine concentrations are thought to be raised by high protein and methionine intakes.

OBJECTIVE:

Our goal was to investigate the effects of high and low protein and methionine intakes on homocysteine in overweight subjects.

DESIGN:

Sixty-five overweight subjects were randomly assigned to a 6-mo intervention with a low-protein, low-methionine diet (LP: 12% of total energy, 1.4 g methionine/d; n = 25); a high-protein, high-methionine diet (HP: 22% of total energy, 2.7 g methionine/d; n = 25), both of which had similar fat contents (30% of total energy); or a control diet with an intermediate protein content (n = 15). All food was self-selected at a shop at the department. Protein intake was increased in the HP group mainly through lean meat and low-fat dairy products. Dietary compliance was evaluated by urinary nitrogen excretion.

RESULTS:

Homocysteine concentrations did not change significantly in the LP or control groups but were 25% lower in the HP group (NS). Homocysteine concentrations after the 3-mo intervention were inversely associated with vitamin B-12 intake and with weight change (by multivariate analysis performed for all subjects), but not with methionine or protein intake. Sixty-nine percent of the variation could be explained by baseline homocysteine (P < 0.001), 2% by vitamin B-12 (P = 0.02), and another 2% by weight change (P = 0.06). The plasma homocysteine concentration after 6 mo was associated only with baseline homocysteine (P < 0.001).

CONCLUSION:

A high-protein, high-methionine diet does not raise homocysteine concentrations compared with a low-protein, low-methionine diet in overweight subjects.
PMID:12450883[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

32.
Nutr Res Rev. 2002 Jun;15(1):91-121. doi: 10.1079/NRR200235.=Alcohol drinking and cardiac risk.=
Buemann B, Dyerberg J, Astrup A.===Source===
Research Department of Human Nutrition and Center for Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg, Denmark. BBU@KVL.DK

Abstract

The present paper provides a comprehensive review of the literature pertaining to the impact of alcohol intake on cardiovascular disease. Both cross-sectional and prospective studies have disclosed a negative association between moderate intake of alcoholic beverages and cardiovascular disease. The relationship appears to be present for both wine, beer and spirits. Effects of alcohol itself and also the role of different cardio-protective substances in alcoholic beverages are discussed. Alcohol has been suggested to beneficially affect the blood lipid profile, as it increases plasma HDL-cholesterol level. Furthermore, it may inhibit thrombogenesis by reducing thromboxan formation and decreasing the plasma level of fibrinogen. However, high blood concentrations of alcohol may impair fibrinolysis by increasing plasma plasminogen activator inhibitor-1 level. This action could contribute to explaining the 'U'-shaped association between alcohol intake and cardiac events. Alcohol seems to promote abdominal fat distribution, but the importance of this effect in non-obese individuals is uncertain. Wine in particular, but also beer, contains polyphenols which act as antioxidants. Their action could maintain the integrity of the endothelial function by reducing the formation of superoxide. Moreover, these antioxidants may protect against LDL oxidation and modulate the macrophage attack on the endothelium. Although the cardio-protective effect of alcohol can hardly be addressed in healthy individuals by intervention studies with hard end points, there are many observational and experimental findings indicating that moderate alcohol drinking possesses properties preventive of cardiovascular disease.
PMID:19087400[PubMed] Related citations
Icon for Cambridge University Press

33.
Ugeskr Laeger. 2002 Mar 4;164(10):1334-8.=[Children, fat and cardiovascular diseases].=
[Article in Danish]
Michaelsen KF, Dyerberg J, Falk E, Hansen HS, Marckmann P, Overvad OK, Schack-Nielsen L, Skovby F, Sørensen KE.===Source===
Arhus Universitetshospital, Skejby Sygehus, koronar-patologisk forskningsenhed og hjertemedicinsk afdeling B.

Abstract

Children do not normally develop atherosclerosis. However, they do develop fatty streaks in the aorta. These are reversible. During the first years of life dietary fat has an influence on blood lipids, and other traditional risk factors influence vascular function, but the consequences are unknown. As saturated fat has no positive effects, the Danish Nutrition Council recommends that the intake of saturated fat is reduced to 10 energy per cent from the age of 12 months. This can be accomplished with semi-skimmed milk (1.5% fat) instead of full-cream milk. During the first year of life, it is recommended that a teaspoon of fat is added to each serving of home made mashed food or porridge to prevent the diet from being so hypocaloric that it has a negative effect on growth.
PMID:11894424[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

34.
Int J Circumpolar Health. 2001 Aug;60(3):360-5.=N-3 fatty acids and cardiac function after myocardial infarction in Denmark.=
Skou HA, Toft E, Christensen JH, Hansen JB, Dyerberg J, Schmidt EB.===Source===
Department of Medicine, Hjørring Hospital, Denmark. helleskou@hotmail.com

Abstract

In order to evaluate the effect of marine n-3 polyunsaturated fatty acids (n-3 PUFA) on systolic left ventricular function, we investigated the effect of daily supplementation with 5.2 g n-3 PUFA for 12 weeks in 55 patients with a recent myocardial infarction in a double blind placebo-controlled design. Left ventricular function was assessed by transthoracal echo-cardiography and plasma concentration of proANP and N-terminal proANP. No effect of n-3 PUFA could be demonstrated on these indices of left ventricular function.
PMID:11590875[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

35.
Ugeskr Laeger. 2001 Apr 23;163(17):2349-53.=[The importance of trans-fatty acids for health. Update 2001].=
[Article in Danish]
Stender S, Dyerberg J.===Source===
Klinisk biokemisk afdeling, Amtssygehuset i Gentofte.

Abstract

The contribution of a high intake of trans fatty acids to the risk of coronary heart disease has gained further support since the report from the Danish Nutrition Council in 1994. Any deleterious effect of trans fatty acids on the human fetus and newborn infants has not been negated. Their possible effect on cancer is still unsettled. The daily intake of trans fatty acids from partially hydrogenated oils in Denmark was in 1994 about 2.5 grams (recommended 2.0 grams) and has since decreased, mainly due to a reduction of the trans fatty acid content in Danish margarines. Population groups with eating habits that include frequent intake of French fries, micro-oven popcorn, chocolate bars, fast food, etc., may consume trans fatty acids in amounts far exceeding the recommended maximum levels. The Danish Nutrition Council recommends that the addition of industrially produced trans fatty acids to food stuffs ceases before 2005 and until then that declaration of the content in foodstuffs becomes mandatory.
PMID:11347454[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

36.
Ugeskr Laeger. 2001 Mar 26;163(13):1830-3.=[Homocysteine and cardiovascular disease].=
[Article in Danish]
Skovby F, Dyerberg J, Nexø E, Osler M, Rasmussen K, Stender S.===Source===
H:S Rigshospitalet, klinisk genetisk afdeling.

Abstract

Treatment of highly increased plasma concentrations of homocysteine in patients with rare inborn errors of metabolism reduces their risk of vascular thromboses. Many, but not all, epidemiological studies show a relation between slightly increased plasma homocysteine and ischaemic cardiovascular disease. Folic acid supplements reduce plasma homocysteine. The results of ongoing studies of the effect of folic acid and other vitamins on the incidence of cardiovascular disease are expected within the next five years. The available data support the measurement of plasma homocysteine as a part of screening of patients with early and/or frequent vascular thromboses and a disparity between established risk factors and symptoms. Plasma homocysteine > 30 mumol/l in such patients should prompt a search for an inborn error of metabolism.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface control[Folic acid fortification]. [Ugeskr Laeger. 2002]

PMID:11293310[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

37.
Circulation. 2001 Feb 6;103(5):651-7.=Marine n-3 fatty acids, wine intake, and heart rate variability in patients referred for coronary angiography.=
Christensen JH, Skou HA, Fog L, Hansen V, Vesterlund T, Dyerberg J, Toft E, Schmidt EB.===Source===
Department of Nephrology, Aalborg Hospital, Aalborg, Denmark. jhc@dadlnet.dk

Abstract

BACKGROUND:

Dietary n-3 polyunsaturated fatty acids (PUFAs) derived from fish may reduce the incidence of sudden cardiac death (SCD). In addition, wine drinking is suggested to have a protective effect against cardiovascular death.

METHODS AND RESULTS:

We included 291 patients referred for coronary angiography in whom ischemic heart disease was suspected and all of whom completed a food questionnaire regarding fish and wine intake. The n-3 PUFA composition of granulocyte membranes and of adipose tissue was measured. In addition, 24-hour heart rate variability (HRV) was analyzed. Fish intake was positively associated with the level of n-3 PUFAs in adipose tissue. Significant positive correlation coefficients were found between HRV indices and the levels of n-3 PUFAs in granulocytes. Wine intake was also significantly positively related to HRV, but the patients with the highest wine intake also had the highest intake of fish, as documented by a high n-3 PUFA content in adipose tissue. Multiple linear regression analysis revealed that traditional factors such as treatment with ss-blockers, smoking, age, and previous myocardial infarction were independently related to HRV, and furthermore that n-3 PUFAs (but not wine intake) were significantly independently associated with HRV.

CONCLUSIONS:

The close positive association between n-3 PUFAs and HRV in patients suspected of having ischemic heart disease may indicate a protective effect of n-3 PUFAs against SCD. This may partly explain the reduction in SCD observed in humans with a modest intake of n-3 PUFA. Wine intake was also positively correlated with HRV, but this correlation was no longer significant after controlling for the cellular level of n-3 PUFA.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlPolyunsaturated fatty acids and cardiovascular events: a fish tale. [Circulation. 2001]

PMID:11156875[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

38.
World Rev Nutr Diet. 2001;88:90-9.=omega 3 fatty acids. From eskimos to clinical cardiology–what took us so long?=
von Schacky C, Dyerberg J.===Source===
University of Munich, Medizinische Klinik Innenstadt, Munich, Germany. vonschacky@medinn.med.uni-muenchen.de
PMID:11935977[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

39.
Ugeskr Laeger. 2000 Apr 3;162(14):2046-50.=[Proper advice on nutrition. Recommendations concerning the conduct of the nutritional news].=
[Article in Danish]
Sørensen TI, Astrup AV, Dyerberg J, Hermansen K, Hyldstrup L, Sandström B, Stender S.===Abstract===
The Committee on Proper Conduct in Public Advice on Nutrition, set up by the Danish Nutrition Council, has produced recommendations to persons involved in communicating results of nutrition research. The guidelines are targeted on scientists, industry, journalists and publishers as well as consumers to facilitate proper conduct in communication of own or other scientists' research results, which might influence consumers' choice and intake of food. The results are presented as recommendations and checklists providing the necessary requirements to bring people in a position to make the best possible evaluation of the new scientific results and to put the results into their proper perspective. The aim of this report is to improve the process so that the communicator focuses on the background information necessary for the reader/listener/viewer in the current situation to achieve a balanced view and benefit from the new scientific result.
PMID:10815521[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms===

40.
Nutr Metab Cardiovasc Dis. 2000 Apr;10(2):57-61.=Alpha-linolenic acid and heart rate variability.=
Christensen JH, Christensen MS, Toft E, Dyerberg J, Schmidt EB.===Source===
Department of Nephrology, Aalborg Hospital, Denmark.

Abstract

BACKGROUND AND AIM:

The marine long-chained n-3 polyunsaturated fatty acids seem to have antiarrhythmic effects in humans. Similar effect has also been postulated for alpha-linolenic acid, a plant-derived polyunsaturated fatty acid–from the n-3 family. The purpose of the study was to examine the relation between the content of alpha-linolenic acid in cell membranes and the risk of malignant arrhythmias as assessed by determination of heart rate variability (HRV).

METHODS AND RESULTS:

Patients at high risk of sudden cardiac death (52 with a previous myocardial infarction and 29 with chronic renal failure on dialysis) were enrolled as well as 64 healthy volunteers. The cell membrane content of alpha-linolenic acid was analyzed by gas chromatography and related to 24-hour HRV, which was measured in all subjects. No correlations were found between levels of alpha-linolenic acid and 24-hour HRV.

CONCLUSION:

The present study was unable to demonstrate a positive correlation between cell membrane levels of alpha-linolenic acid and HRV. Our results suggest that alpha-linolenic acid per se is devoid of an antiarrhythmic effect, though this effect could arise from its conversion to the longer chained n-3 PUFA, usually derived from fish.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlWhy do coronary patients gain a clinical benefit from polyunsaturated fatty acids? [Nutr Metab Cardiovasc Dis. 2000]

PMID:10919169[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

41.
Public Health Nutr. 2000 Mar;3(1):91-8.=N-3 fatty acids from fish and coronary artery disease: implications for public health.=
Schmidt EB, Skou HA, Christensen JH, Dyerberg J.===Source===
Department of Medicine, Hjørring/Brønderslev Hospital, Hjørring, Denmark. ebs@dadlnet.dk

Abstract

OBJECTIVE:

To review and discuss the effect of n-3 polyunsaturated fatty acids (PUFA) from fish in the prevention and, primarily, in the treatment of coronary artery disease (CAD).

DESIGN:

Overview of the literature.

SETTING:

Denmark.

RESULTS:

There is good evidence that fish consumption may reduce the risk of CAD.

CONCLUSIONS:

Fish can be recommended to reduce the risk of CAD both in healthy subjects and in patients with a high risk of CAD or with documented CAD. The use of fish oil concentrates can not be recommended in general, but may be considered in patients after a myocardial infarction or in patients with hypertriglyceridaemia. An increased intake of n-3 polyunsaturated fatty acids from fish may have substantial implications for public health and health economy by decreasing the risk of coronary events and sudden cardiac death.
PMID:10786728[PubMed – indexed for MEDLINE] Related citations
Icon for Cambridge University Press
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

42.
Am J Clin Nutr. 1999 Sep;70(3):331-7.=Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids.=
Christensen JH, Christensen MS, Dyerberg J, Schmidt EB.===Source===
Department of Nephrology, Aalborg Hospital, Aalborg, Denmark.

Abstract

BACKGROUND:

Dietary intake of long-chain n-3 polyunsaturated fatty acids (PUFA) may protect against sudden cardiac death, an event that may be predicted by measurement of heart rate variability (HRV).

OBJECTIVE:

The objectives of this study were to 1) examine the correlations between the content of fatty acids in blood cell membranes (platelets and granulocytes) and HRV in healthy subjects, and 2) assess the effect on HRV of dietary intervention with n-3 PUFA in different doses.

DESIGN:

Sixty healthy volunteers (25 women and 35 men) were randomly assigned to 3 treatment groups in a double-blind design. Subjects received a daily supplement of either 6.6 g n-3 PUFA, 2.0 g n-3 PUFA, or placebo (olive oil). A 24-h Holter recording was obtained for each subject before supplementation and after 12 wk of supplementation; the 24-h HRV was then related to the content of fatty acids in granulocytes and platelets.

RESULTS:

Before supplementation, positive correlations were observed in men between the content of docosahexaenoic acid in cell membranes and HRV indexes (r = 0.50, P < 0.01), whereas such correlations were not found in women. Dietary intervention revealed a dose-dependent effect of n-3 PUFA on HRV in men, whereas no effect was found in women.

CONCLUSION:

The study showed a beneficial effect of n-3 PUFA on HRV in healthy men, suggesting an antiarrhythmic effect of n-3 PUFA. No such effect was observed in healthy women.
PMID:10479194[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

43.
Lipids. 1999;34 Suppl:S303-5.=n-3 fatty acids and coronary heart disease–the urgent need of clinical trials.=
Schmidt EB, Dyerberg J.===Source===
Department of Medicine, Hjørring/Brønderslev Hospital, Copenhagen K, Denmark. ebs@dadlnet.dk
PMID:10419185[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

44.
Lipids. 1999;34 Suppl:S197.=n-3 fatty acids and the risk of sudden cardiac death assessed by 24-hour heart rate variability.=
Christensen JH, Dyerberg J, Schmidt EB.===Source===
Department of Nephrology, Aalborg Hospital, Copenhagen, Denmark. jhc@dadlnet.dk
PMID:10419147[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

45.
Clin Nephrol. 1998 Feb;49(2):102-6.=Heart rate variability and n-3 fatty acids in patients with chronic renal failure–a pilot study.=
Christensen JH, Aarøe J, Knudsen N, Dideriksen K, Kornerup HJ, Dyerberg J, Schmidt EB.===Source===
Department of Endocrinology, Aalborg Hospital, Denmark.

Abstract

Patients with chronic renal failure (CRF) often have autonomic cardiac dysfunction, which can be assessed by measuring heart rate variability (HRV). This dysfunction prediposes the patients to sudden cardiac death. This study describes 24-hour HRV in patients with CRF compared to HRV in patients with a previous myocardial infarction (MI). Furthermore, associations between HRV in patients with CRF and the content of n-3 polyunsaturated fatty acids (PUFA) in cell membranes were examined, because n-3 PUFA may improve HRV. Twenty-nine patients with CRF treated with dialysis were enrolled. A 24-hour Holter recording was obtained at baseline and the HRV variables, RR (= mean of all normal RR intervals during the 24-hour recording) and SDNN (= standard deviation of all normal RR intervals in the entire 24-hour recording) were analyzed. Also, granulocyte fatty acid composition was determined. The patients were allocated to dietary supplementation with either 5.2 g of n-3 PUFA or a placebo oil (olive oil) daily for 12 weeks in a double-blind design. At the end of the supplementation period the Holter recording and blood sampling were repeated. At baseline the CRF patients' mean SDNN ws 86 ms compared to 118 ms (p < 0.01) in patients with a previous MI. After supplementation with either n-3 PUFA or placebo a highly significant correlation was observed between the content of n-3 PUFA in cell membranes and HRV (r = 0.71, p < 0.01). Furthermore, when the patients were dichotomized according to their mean SDNN, it was found, that those with the highest SDNN had a higher content of n-3 PUFA in cell membranes compared to those with the lowest SDNN (7.8% vs 4.2%, p < 0.05). In conclusion, HRV was decreased in CRF patients indicating a cardiovascular autonomic dysfunction. The positive correlation between the n-3 PUFA content in cell membranes and HRV suggests that the effects of an increased intake of n-3 PUFA in CRF patients should be further studied.
PMID:9524780[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

46.
Scand J Clin Lab Invest. 1997 Oct;57(6):495-9.=n-3 fatty acids do not decrease plasma endothelin levels in healthy individuals.=
Christensen MS, Therkelsen K, Møller JM, Dyerberg J, Schmidt EB.===Source===
Department of Medicine B, Hjørring-Brønderslev Hospital, Denmark.

Abstract

The effect of three different doses of n-3 polyunsaturated fatty acids (PUFA) on endothelin-1 (ET-1) was studied. Study 1 included 40 healthy volunteers randomized to a single supplement of 20 g of n-3 or n-6 PUFA. Plasma ET-1 was measured 14 h after ingestion, and no changes in plasma ET-1 after intake of n-3 PUFA were observed, compared to baseline values. In study 2, 32 subjects had 0.65 g of n-3 PUFA or a fat mixture per day for 12 weeks. No changes in plasma ET-1 were found after the oil supplements. Finally, 22 persons had 4 g of n-3 PUFA for 6 weeks. A significant increase in plasma ET-1 was seen in this group after the supplement. Thus, n-3 PUFAs do not lower plasma levels of ET-1, the most potent vasoconstrictor known.
PMID:9350068[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

47.
Ugeskr Laeger. 1997 Sep 8;159(37):5525-9.=[n-3 polyunsaturated fatty acids, heart rate variability and ventricular arrhythmias in post-AMI-patients. A clinical controlled trial].=
[Article in Danish]
Christensen JH, Gustenhoff P, Korup E, Aarøe J, Toft E, Møller JM, Rasmussen K, Dyerberg J, Schmidt EB.===Source===
Aalborg Sygehus, medicinsk endokrinologisk afdeling.

Abstract

There is evidence for an antiarrhythmic effect of n-3 polyunsaturated fatty acids (n-3 PUFA) in animals. The aim of the present study was to investigate the effect of dietary n-3 PUFA on ventricular arrhythmias and heart rate variability (HRV) in patients with a previous myocardial infarction. Fifty-five patients were randomized to receive either 5.2 g of n-3 PUFA daily for 12 weeks or placebo in a double blind, placebo-controlled study. Prior to randomization a 24-hour Holter recording was obtained, and this was repeated at the end of the study. The major end-points were the number of ventricular extrasystoles (VE)/24 hours and the 24-hour HRV. A non-significant decrease in VE/24 hours was found in both the n-3 PUFA group and among controls after dietary supplementation, whereas HRV significantly increased after n-3 PUFA compared to both baseline values (p = 0.04) and to controls (p = 0.01). The present study therefore supports the hypothesis that n-3 PUFA may have an anti-arrhythmic effect in humans.
PMID:9312922[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

48.
Am J Cardiol. 1997 Jun 15;79(12):1670-3.=Fish consumption, n-3 fatty acids in cell membranes, and heart rate variability in survivors of myocardial infarction with left ventricular dysfunction.=
Christensen JH, Korup E, Aarøe J, Toft E, Møller J, Rasmussen K, Dyerberg J, Schmidt EB.===Source===
Department of Endocrinology, Aalborg Hospital, Denmark.

Abstract

To elucidate a possible antiarrhythmic effect of long-chained n-3 polyunsaturated fatty acids, heart rate variability was assessed in 52 patients with a previous myocardial infarction and left ventricular dysfunction. The content of n-3 polyunsaturated fatty acids in platelets was closely associated with the patient's fish-consuming habits, and a significant positive correlation was observed between the n-3 fatty acid docosahexaenoic acid and heart rate variability.
PMID:9202361[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

49.
Thromb Res. 1997 May 15;86(4):333-5.=Homocysteine in Greenland Inuits.=
Møller JM, Nielsen GL, Ekelund S, Schmidt EB, Dyerberg J.===Source===
Department of Medical Gastroenterology, Aalborg Hospital, Denmark.

Abstract

Patients with homozygous homocystinuria are at greatly increased risk for development of atherosclerosis and thrombosis (1). Elevated plasma levels of homocysteine (HCY) are caused by reduced enzymatic catabolism or reduced enzymatic remethylation of HCY, due to either hereditary enzyme defects or to nutritional deficiencies of vitamins functioning as cofactors. However, several recent studies have suggested that persons with mildly elevated plasma levels of HCY also are at increased risk for coronary heart disease. (2-4). There are some indications that dietary n-3 polyunsaturated fatty acids (PUFAs) may offer protection against coronary heart disease (5-6). Several mechanisms may be involved, including beneficial effects of n-3 PUFAs on plasma lipids, platelet and leukocyte reactivity, blood pressure and vasoreactivity (7). Interestingly, Olszewski el al. recently found HCY-levels to be lowered 36% in 15 type IIa or IIb hyperlipemic men by n-3 PUFA supplementation. A possible beneficial effect of n-3 PUFA on the incidence of coronary heart disease was initially suggested from studies in Greenland Inuits by our group (8). We therefore investigated plasma levels of homocysteine in a group of traditionally living Greenland Inuits with a diet consisting mainly of marine food and with a very high content of n-3 PUFAs.
PMID:9187021[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

50.
Ugeskr Laeger. 1997 Feb 17;159(8):1119-21.=[Diet and secondary prevention of ischemic heart disease].=
[Article in Danish]
Stender S, Astrup AV, Dyerberg J, Faergeman O, Godtfredsen J, Marckmann P, Viggers L, Lind EM.PMID:9072862[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

51.
Diabetes Care. 1996 Dec;19(12):1382-7.=Increased plasma apolipoprotein (a) levels in IDDM patients with diabetic nephropathy.=
Tarnow L, Rossing P, Nielsen FS, Hansen BV, Dyerberg J, Parving HH.===Source===
Steno Diabetes Center, Gentofte, Denmark.

Abstract

OBJECTIVE:

The relative mortality from cardiovascular disease (CVD) is increased 40-fold in IDDM patients suffering from diabetic nephropathy as compared with nondiabetic subjects on average. We assessed the potential contribution of dyslipidemia in general and elevated serum apolipoprotein (a) [apo(a)] in particular to CVD in nephropathic patients with IDDM.

RESEARCH DESIGN AND METHODS:

We investigated 199 IDDM patients with diabetic nephropathy and 192 normoalbuminuric IDDM patients matched for sex, age, diabetes duration, and BMI.

RESULTS:

The prevalence of CVD was 30 and 12% in patients with and without nephropathy, respectively (P < 0.001). The level of apo(a) was significantly higher in patients with nephropathy, 189 (20-2,350) U/l as compared with the normoalbuminuric group, 103 (20-1,940) U/l (P < 0.005). The prevalence of plasma apo(a) > 300 U/l (at-risk level for cardiovascular pathogenicity) was 38% (31-45) vs. 22% (16-28) in patients with and without nephropathy, respectively (P < 0.0005). In nephropathic patients, the prevalence of plasma apo(a) > 300 U/l was raised in patients with CVD (48%, 36-61%) as compared with patients without (34%, 26-42%) (P = 0.05). Furthermore, the serum concentrations of the following apolipoproteins and lipids were higher in patients with nephropathy as compared with normoalbuminuric patients: apoB 1.33 +/- 0.37 vs. 1.06 +/- 0.26 g/l; total cholesterol 5.6 +/- 1.2 vs. 4.8 +/- 0.9 mmol/l; and triglycerides 1.22 (0.31-9.87) vs. 0.77 (0.28-3.05) mmol/l, P < 0.0001. Multiple logistic regression analysis of cardiovascular risk factors revealed that plasma apo(a) concentration > 300 U/l is an independent risk factor for coronary heart disease, odds ratio 1.86 (1.03-3.36) (P < 0.05).

CONCLUSIONS:

Dyslipidemia and raised plasma concentrations of apo(a), particularly > 300 U/l, may contribute to the enhanced morbidity and mortality from CVD characteristically observed in IDDM patients with diabetic nephropathy.
PMID:8941468[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

52.
Ugeskr Laeger. 1996 Nov 25;158(48):6885-91.=[Significance of food for patients with ischemic heart disease].=
[Article in Danish]
Stender S, Astrup AV, Dyerberg J, Faergeman O, Godtfredsen J, Lind EM, Marckmann P, Viggers L.PMID:8984749[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms===

53.
Hum Genet. 1996 Nov;98(5):546-50.=The apolipoprotein E polymorphism in Greenland Inuit in its global perspective.=
Gerdes LU, Gerdes C, Hansen PS, Klausen IC, Faergeman O, Dyerberg J.===Source===
Department of Clinical Biochemistry, Aarhus Kommunehospital, University of Aarhus. lugerdes@post4.tele.dk

Abstract

Apolipoprotein E (apoE) genotypes were determined in Inuit population samples from Nuuk on the south-west coast of Greenland (n = 100) and from the Ammassalik region on the south-east coast (n = 78). The epsilon 2 allele was absent in the latter sample, and the epsilon 4 allele frequency was relatively high, about 23%. As in most other populations, mean plasma lipoprotein-related variables, except high-density lipoprotein (HDL) cholesterol, were higher in both Inuit men and women with epsilon 4 than in epsilon 3 epsilon 3 genotypes (P < 0.05 for triglycerides in men, and for non-HDL cholesterol and apolipoprotein B in women). The estimated apoE allele frequencies were combined with data from other studies of aboriginal peoples to outline a world map of apoE allele frequencies. A recent study of non-human primates suggests that epsilon 4, and not epsilon 3, is the ancestral allele in humans and we have used the map to generate additional hypotheses regarding the history of the apoE polymorphism in humans.
PMID:8882873[PubMed – indexed for MEDLINE] Related citations
Icon for Springer
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

54.
BMJ. 1996 Mar 16;312(7032):677-8.=Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial.=
Christensen JH, Gustenhoff P, Korup E, Aarøe J, Toft E, Møller J, Rasmussen K, Dyerberg J, Schmidt EB.===Source===
Department of Endocrinology, Aalborg Hospital, Aalborg, Denmark.
PMID:8597736[PubMed – indexed for MEDLINE] PMCID:PMC2350515 Free PMC ArticleRelated citations
Icon for HighWireIcon for PubMed Central
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

55.
Scand J Clin Lab Invest. 1996 Feb;56(1):87-92.=No effect of a very low dose of n-3 fatty acids on monocyte function in healthy humans.=
Schmidt EB, Varming K, Møller JM, Bülow Pedersen I, Madsen P, Dyerberg J.===Source===
Department of Medicine, Aalborg Hospital, Copenhagen, Denmark.

Abstract

There is some evidence that intake of sea food rich in n-3 polyunsaturated fatty acids (PUFA) may protect against coronary heart disease (CHD). Thus, even very low daily amounts of n-3 PUFA below 0.5 g have been reported to reduce the incidence of CHD, although it is unknown by what mechanisms this may occur. Monocytes are of major importance in atherogenesis, and we therefore studied the effect of a daily supplement with 0.65 g of n-3 PUFA for 12 weeks on monocyte function in a randomized placebo-controlled trial of 32 healthy subjects. No effect of dietary n-3 PUFA could be demonstrated on monocyte chemotaxis, on chemiluminescence, or on formation of cytokines and leukotriene B4 from activated monocytes.
PMID:8850177[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

56.
Nutrition. 1995 Sep-Oct;11(5):475; discussion 474, 476.=Haemostatic function and platelet polyunsaturated fatty acids in Eskimos. 1979.=
Dyerberg J, Bang HO.PMID:8748204[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms, Substances, Personal Name as Subject===

57.
Ugeskr Laeger. 1995 Jul 10;157(28):4039-41.=[Long-chain polyunsaturated fatty acids and milk substitutes].=
[Article in Danish]
Dyerberg J.===Comment on===

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface control[Importance of n-3 and n-6 fatty acids for visual function and development in newborn infants]. [Ugeskr Laeger. 1995]

PMID:7645083[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

58.
Clin Sci (Lond). 1995 Apr;88(4):375-92.=The influence of trans fatty acids on health: a report from the Danish Nutrition Council.=
Stender S, Dyerberg J, Hølmer G, Ovesen L, Sandström B.===Source===
Danish Nutrition Council, Copenhagen.

Abstract

Trans fatty acids constitute 0-30% of the fat in Danish margarines, most in industry and bakery margarines and usually less in table margarine. The trans fatty acids make margarines more solid at room temperature and therefore provide an economical storage advantage. In British and U.S. reports from 1984-1989, the trans fatty acids were more or less acquitted of unhealthy effects. During the last 5-6 years, however, a series of new studies has been published regarding both the connection between the consumption of trans fatty acids and the occurrence of coronary heart disease and the impact on the lipoprotein level in plasma. Studies suggest that the consumption of trans fatty acids from margarine is equally, or perhaps more, responsible for the development of arteriosclerosis than saturated fatty acids. In addition, it is now clear that both the fetus and the breast-fed baby are exposed to trans fatty acids in relation to the mother's consumption. A couple of recent studies suggest a possible restrictive influence of the trans fatty acids on the weight of the fetus. The average consumption of trans fatty acids from margarine in Denmark in 1991 was approximately 2.5 g/day per person. For about 150,000 adult Danes, the consumption is assumed to be more than 5 g/day per person. On this basis, the Danish Nutrition Council recommend that the consumption of trans fatty acids is reduced as much as possible. This can be done by reducing the fat content in food and by reducing the trans fatty acid content in all Danish margarine products to 5% or less. Thereafter, the group of adult Danes, including pregnant and breast-feeding women, with a large consumption of margarine and margarine-containing products, will on average only consume 2 g of vegetable trans fatty acids/day. This corresponds to the consumption in the low-risk groups in the above-mentioned epidemiological studies. In addition, the Danish Nutrition Council encourage the producers of margarines to make products that can be marketed as 'free of trans fatty acids'.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlThe influence of trans fatty acids on health. [Clin Sci (Lond). 1995]

PMID:7789038[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

59.
Scand J Clin Lab Invest. 1995 Feb;55(1):47-52.=The effect of n-3 fatty acids on neutrophil chemiluminescence.=
Varming K, Schmidt EB, Svaneborg N, Møller JM, Lervang HH, Grunnet N, Jersild C, Dyerberg J.===Source===
Department of Clinical Immunology, Aalborg Hospital, Denmark.

Abstract

The effect of dietary supplementation with n-3 polyunsaturated fatty acids (PUFAs) on the production of free oxygen radicals from activated neutrophils was investigated in healthy subjects, using chemiluminescence. In the first study 22 persons were give 4 g n-3 PUFAs daily for 6 weeks. There was a median reduction of chemiluminescence from neutrophils stimulated with opsonized zymosan of 37% (p < 0.001). The median content of eicosapentaenoic acid in platelets, used as an indicator for cellular fatty acid profile, increased from 0.70 to 2.80% (p < 0.001), and there was a significant negative correlation between the chemiluminescence signal and the content of eicosapentaenoic acid in platelets (p < 0.001). In a second, low-dose study 24 persons were allocated to daily supplementation with either 0.65 g n-3 PUFAs or with a control oil for 6 weeks. Compared to the control group there was a median reduction of 38 and 44% in chemiluminescence from neutrophils stimulated with opsonized zymosan and phorbol,12-myristate,13-acetate (PMA), respectively. Neither of these differences, however, was statistically significant. These findings lend support for a possible role of n-3 PUFAs in the management of inflammatory disorders.
PMID:7624736[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

60.
Ugeskr Laeger. 1994 Dec 19;156(51):7675-9.=[The effect on health of dietary antioxidants and antioxidant supplements].=
[Article in Danish]
Sandström B, Astrup AV, Dyerberg J, Hølmer G, Poulsen HE, Stender S, Kondrup J, Gudmand-Høyer E.===Source===
Ernaeringsrådet, København.

Abstract

Reactive free oxygen radicals are formed in the reactions involved in normal cell metabolism. This formation is closely regulated e.g. by dietary antioxidants. Present knowledge suggests that an imbalance, with surplus of free radicals, can play a role in the pathogenesis of certain types of cancer, atherosclerosis, and cataract. A number of epidemiological studies have demonstrated a reduced risk of developing these diseases in persons who consume a diet with a high content of vegetables and fruit, which contains large quantities of the antioxidants: beta-carotene, vitamins C and E. Intervention studies, using supplements of these antioxidants, have so far not been able to show a beneficial effect. The apparently protective effect of fruit and vegetables may be due to other active ingredients. In Denmark the average intake of vegetables and fruit is low, and it is estimated that an increased consumption of these foods could reduce the occurrence of certain cancer types and atherosclerosis. In contrast, there is no evidence that antioxidant supplements would provide protection against disease, and their safety remains to be established.
PMID:7839531[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

61.
Ugeskr Laeger. 1994 Sep 19;156(38):5536-7.=[Osteoporosis profile].=
[Article in Danish]
Dyerberg J.PMID:7941092[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

62.
Ugeskr Laeger. 1994 Jun 20;156(25):3764-9.=[Significance of trans-fatty acids for health].=
[Article in Danish]
Stender S, Dyerberg J, Hølmer G, Ovesen L, Sandström B.===Abstract===
Trans fatty acids make up 0-30% of the fatty acids in Danish margarines. The intake of trans fatty acids from margarine in Denmark was in 1991 on average about 2.5 gram/person/day, and for about 150,000 Danes more than 5 gram/person/day. Several recent case-control studies and a large cohort study as well as clinical ward studies suggest that the intake of trans fatty acids enhances atherogenesis to the same extent or possibly even more than saturated fatty acids. In addition a few studies suggest that the intake of trans fatty acids by the pregnant mother impairs growth of the human foetus. On this background it seems reasonable to reduce the intake of trans fatty acids as much as possible. This could be implemented by a reduction in the fat content of the diet together with a reduction of trans fatty acid content to less than 5% in all margarines. This would ensure that Danes–including pregnant and nursing women–with a high intake of margarine on average consume less than 2 gram of trans fatty acids of vegetables origin per day. This amount corresponds to intake in low risk groups in several studies.
PMID:8059455[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

63.
Ugeskr Laeger. 1994 Jun 6;156(23):3495-8.=[Fish oils and rheumatoid arthritis. A randomized and double-blind study].=
[Article in Danish]
Faarvang KL, Nielsen GL, Thomsen BS, Teglbjaerg KL, Hansen TM, Lervang HH, Schmidt EB, Dyerberg J, Ernst E.===Source===
Reumatologisk afdeling, Amtssygehuset i Herlev.

Abstract

The effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with active rheumatoid arthritis was evaluated in a multicentre, randomized and double blind study. Fifty-one patients with active rheumatoid arthritis were included from three Danish hospital Departments of Rheumatology. The patients were allocated to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with a fat composition averaging the Danish diet. Small but significant improvements in morning stiffness, joint tenderness and C-reactive protein were observed. There were no serious side-effects. Dietary supplementation with n-3 PUFA in patients with active rheumatoid arthritis has a modest effect on three out of eight disease variables, without effect on other traditional parameters for monitoring disease activity.
PMID:8066866[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

64.
Drugs. 1994 Mar;47(3):405-24.=Omega-3 fatty acids. Current status in cardiovascular medicine.=
Schmidt EB, Dyerberg J.===Source===
Department of Medicine and Hematology, Aalborg Hospital, Denmark.

Abstract

Omega-3 polyunsaturated fatty acids (PUFA) reduce fasting and postprandial triglycerides, decrease platelet and leucocyte reactivity, and may slightly decrease blood pressure. Omega-3 PUFA may also beneficially influence vessel wall characteristics and blood rheology. Furthermore, these compounds have been shown to inhibit ventricular tachyarrhythmias in animals. Omega-3 PUFA may impair fibrinolysis and could lead to increased oxidation of lipoproteins. Potential adverse effects must not be neglected, but should be viewed in light of the beneficial effects of these agents. Clinical studies investigating the effects of dietary omega-3 PUFA in the prevention and treatment of cardiovascular disease (CVD) are beginning to emerge. The results have offered some promise, but further studies are needed to define the role of these agents in CVD. Long term trials and studies using omega-3 PUFA as adjuvants to conventional therapy in patients with coronary artery disease, hyperlipidaemia and hypertension may be of particular interest.
PMID:7514972[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

65.
Lipids. 1994 Feb;29(2):145-7.=The acute effects of a single very high dose of n-3 fatty acids on plasma lipids and lipoproteins in healthy subjects.=
Svaneborg N, Møller JM, Schmidt EB, Varming K, Lervang HH, Dyerberg J.===Source===
Department of Haematology, Aalborg Hospital, Denmark.

Abstract

Forty healthy volunteers were allocated in a double blind, randomized study to receive either 20 g of n-3 polyunsaturated fatty acids (PUFA) or 20 g of n-6 PUFA at their evening meal. The effect on plasma lipids and lipoproteins of this single dose of fish oil vs. corn oil was studied the next morning, 14 h after ingestion. Plasma triglycerides and very low density lipoprotein-cholesterol significantly decreased (33%) after n-3 PUFA (P < 0.001), and significantly (P < 0.01) more than after intake of n-6 PUFA. The decrease in plasma triglycerides after n-3 PUFA ingestion was more pronounced in subjects with higher baseline levels of triglycerides (P < 0.001). Total cholesterol decreased after both supplements, but did not differ between the supplements. Low density lipoprotein-cholesterol did not change, and high density lipoprotein-cholesterol significantly decreased in subjects given n-3 PUFA compared to baseline, but not when compared to subjects receiving n-6 PUFA. In conclusion, we have shown that a single very high dose of n-3 PUFA has a pronounced hypotriglyceridemic effect, which is directly related to the initial plasma level.
PMID:8152348[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

66.
World Rev Nutr Diet. 1994;76:133-6.=The epidemiology of omega 3 fatty acids.=
Dyerberg J.===Source===
Medi-Lab A.S., Copenhagen, Denmark.
PMID:7856223[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

67.
Scand J Clin Lab Invest. 1993 Jul;53(4):417-23.=The effect of low-dose supplementation with n-3 polyunsaturated fatty acids on some risk markers of coronary heart disease.=
Lervang HH, Schmidt EB, Møller J, Svaneborg N, Varming K, Madsen PH, Dyerberg J.===Source===
Department of Medicine, Aalborg Hospital, Denmark.

Abstract

Epidemiological data have suggested that a low dose of dietary n-3 polyunsaturated fatty acids from seafood may protect against coronary heart disease. We studied the effect of supplementation with a low dose of very long-chain n-3 fatty acids (0.65 g day-1) on plasma lipids, haemostasis, and neutrophil aggregation. Twenty-four healthy subjects were randomized to supplementation with very long-chain n-3 fatty acids or a control oil for 8 weeks. Laboratory analyses were done twice before and twice at the end of the supplementation period. The supplement with n-3 polyunsaturated fatty acid did not significantly affect plasma lipids or plasma levels of fibrinogen, factor VII, plasminogen activator inhibitor, whole blood aggregation or aggregability of neutrophil leukocytes. Therefore, the potential beneficial effect of very long-chain n-3 fatty acids in coronary heart disease is likely to be mediated through other mechanisms.
PMID:8378746[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

68.
Eur J Clin Nutr. 1993 Jun;47(6):431-6.=No effect of human serum and erythrocytes enriched in n-3 fatty acids by oral intake on Plasmodium falciparum blood stage parasites in vitro.=
Abu-Zeid YA, Hansen HS, Jakobsen PH, Bygbjerg IC, Dyerberg J.===Source===
Department of Infectious Diseases, University Hospital (Rigshospitalet), Copenhagen, Denmark.

Abstract

To examine the effect of n-3 polyunsaturated fatty acids (n-3 PUFA) on the erythrocytic growth of Plasmodium falciparum, serum and erythrocytes were separated from blood of a healthy donor before and after he had taken fish oil capsules for 8 days. Such intake supplied an amount of eicosapentaenoic acid (EPA, 20:5n-3) of 3.5 g/d and docosahexaenoic acid (DHA, 22:6n-3) of 2.5 g/d and 24 mg/d of total tocopherol. Post-intake fish oil serum (post-s) and erythrocytes (post-e) were tested in vitro for inhibitory activity against blood stages of P. falciparum compared with pre-intake serum (pre-s) and pre-intake erythrocyte (pre-e). Also the effect of EPA and arachidonic acid (AA, 20:4n-6) on the erythrocytic growth of P. falciparum was tested using in vitro assays. The results show that both post-s and post-e had no antimalarial activity on P. falciparum. No differential antimalarial effect was observed for 20:5n-3 compared with 20:4n-6, which at high concentrations (> 40 microM) had an anti-schizont-growth effect.
PMID:8365384[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

69.
Diabetologia. 1993 May;36(5):438-44.=Apolipoprotein(a) and cardiovascular disease in type 2 (non-insulin-dependent) diabetic patients with and without diabetic nephropathy.=
Nielsen FS, Voldsgaard AI, Gall MA, Rossing P, Hommel E, Andersen P, Dyerberg J, Parving HH.===Source===
Steno Diabetes Center, Gentofte, Denmark.

Abstract

The relative mortality from cardiovascular disease is on average increased five-fold in Type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy compared to non-diabetic subjects. We assessed the possible contribution of dyslipidaemia in general and elevated serum apolipoprotein(a) (apo(a)) in particular. Type 2 diabetic patients with normo-, micro- and macroalbuminuria were compared with healthy subjects. Each group consisted of 37 subjects matched for age, sex and diabetes duration. Serum creatinine in the nephropathy group was 105 (54-740) mumol/l. The prevalence of ischaemic heart disease (resting ECG, Minnesota, Rating Scale) was 57, 35, 19 and 2% in macro-, micro- and normoalbuminuric diabetic patients and healthy subjects, respectively. The prevalence of ischaemic heart disease was higher in all diabetic groups as compared to healthy subjects (p < 0.05), and higher in macroalbuminuric as compared to normoalbuminuric diabetic patients (p < 0.01). There was no significant difference between apo(a) in the four groups: 161 (10-1370), 191 (10-2080), 147 (10-942), 102 (10-1440) U/l (median (range)) in macro-, micro- and normoalbuminuric groups and healthy subjects. Serum total-cholesterol, HDL-cholesterol and LDL-cholesterol were not significantly different when comparing healthy subjects and each diabetic group. Apolipoprotein A-I was lower (p < 0.05) in all diabetic groups as compared to healthy subjects (nephropathy vs healthy subjects): 1.50 +/- 0.25 vs 1.69 +/- 0.32 g/l (mean +/- SD). Triglyceride was higher (p < 0.05) in patients with nephropathy and microalbuminuria as compared to healthy subjects (nephropathy vs healthy subjects): 2.01 (0.66-14.7) vs 1.09 (0.41-2.75) mmol/l (median (range)).(ABSTRACT TRUNCATED AT 250 WORDS)
PMID:8314449[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

70.
Ugeskr Laeger. 1993 Mar 15;155(11):810-4.=[Hyperlipidemia in children].=
[Article in Danish]
Skovby F, Dyerberg J, Faergeman O, Haghfelt T, Jensen TJ, Leth A, Sigurd B, Stender S, Vittrup MA.===Source===
Rigshospitalet, Børneafdeling GGK, Afsnit for klinisk genetik, København.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface control[Doubtful advices on cholesterol screening in children]. [Ugeskr Laeger. 1993]

PMID:8460436[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms===

71.
Eur J Clin Invest. 1992 Oct;22(10):687-91.=The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial.=
Nielsen GL, Faarvang KL, Thomsen BS, Teglbjaerg KL, Jensen LT, Hansen TM, Lervang HH, Schmidt EB, Dyerberg J, Ernst E.===Source===
Department of Rheumatology, Aalborg Hospital, Copenhagen, Denmark.

Abstract

STUDY OBJECTIVE:

To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis.

DESIGN:

Multicenter, randomized, placebo controlled, double blind.

SETTING:

Three Danish hospital Departments of Rheumatology.

PATIENTS:

Fifty-one patients with active rheumatoid arthritis.

INTERVENTION:

Random allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet.

MAIN RESULTS:

Significant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects.

CONCLUSIONS:

Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.
PMID:1459173[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

72.
Scand J Clin Lab Invest. 1992 Oct;52(6):513-21.=Apolipoprotein(a) in insulin-dependent diabetic patients with and without diabetic nephropathy.=
Gall MA, Rossing P, Hommel E, Voldsgaard AI, Andersen P, Nielsen FS, Dyerberg J, Parving HH.===Source===
Steno Memorial and Hvidöre Hospital, Klampenborg, Denmark.

Abstract

Insulin-dependent diabetic patients with diabetic nephropathy have a highly increased morbidity and mortality from cardiovascular diseases. To determine whether altered levels of apolipoprotein(a) (apo(a)), the glycoprotein of the potentially atherogenic lipoprotein(a) (Lp(a)), contribute to the increased risk of ischaemic heart disease, apo(a) was determined in 50 insulin-dependent diabetic patients with diabetic nephropathy (group 1), in 50 insulin-dependent diabetic patients with microalbuminuria (group 2), in 50 insulin-dependent diabetic patients with normoalbuminuria (group 3), and in 50 healthy subjects (group 4). The groups were matched with regard to sex, age and body mass index. The diabetic groups were also matched with regard to diabetes duration. The level of apo(a) was approximately the same in the four groups, being: 122 (x/ divided by 4.2) U l-1, 63 (x/ divided by 4.4) U l-1, 128 (x/ divided by 3.5) U l-1 and 126 (x/ divided by 3.7) U l-1 (geometric mean (x/ divided by antilog SD)) in group 1, 2, 3 and 4, respectively. 1 U l-1 apo(a) approximates 0.7 mg l-1 Lp(a).(ABSTRACT TRUNCATED AT 250 WORDS)
PMID:1411263[PubMed – indexed for MEDLINE] Related citations
Icon for Informa Healthcare
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

73.
Clin Rheumatol. 1992 Sep;11(3):393-5.=Decreased interleukin-1 beta levels in plasma from rheumatoid arthritis patients after dietary supplementation with n-3 polyunsaturated fatty acids.=
Espersen GT, Grunnet N, Lervang HH, Nielsen GL, Thomsen BS, Faarvang KL, Dyerberg J, Ernst E.===Source===
Department of Clinical Immunology, Aalborg Hospital, Denmark.

Abstract

The effects of dietary supplementation with n-3 fatty acids on the level of cytokines and complement activation in plasma from patients with rheumatoid arthritis were examined. Thirty-two patients with active rheumatoid arthritis were included in a 12-week double-blind, randomized study of dietary supplementation with n-3 fatty acids (3.6 g per day) or placebo. The cytokines were measured in plasma before and after treatment with fish oil or placebo. In general, cytokine values at the upper limits of the calculated normal areas were found. The Interleukin-1 beta concentration in plasma was reduced significantly after 12 weeks of dietary supplementation with fish oil (p < 0.03). No significant difference was observed in the placebo group. The tumour necrosis factor alpha activity in plasma did not change significantly (p = 0.167). No significant changes were observed in the degree of complement activation. The clinical status of the patients was improved in the fish oil group, but not in the placebo group, judged by Ritchie's articular index (p < 0.02). We conclude that dietary supplementation with n-3 fatty acids results in significantly reduced plasma IL-1 beta levels in patients with rheumatoid arthritis. Even though the cytokine levels were low, the anti-inflammatory effect of n-3 fatty acids could in part be explained by their ability to decrease cytokine production.
PMID:1458789[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

74.
Thromb Res. 1992 Sep 1;67(5):569-77.=The acute effect of a single very high dose of N-3 fatty acids on coagulation and fibrinolysis.=
Møller JM, Svaneborg N, Lervang HH, Varming K, Madsen P, Dyerberg J, Schmidt EB.===Source===
Department of Endocrinology, Aalborg Hospital, Copenhagen.

Abstract

The objective of the study was to investigate the acute effect of a single very high dose of n-3 PUFA on coagulation and fibrinolysis. Forty healthy volunteers were randomized into two groups to receive either 20 grams of n-3 PUFA or 20 grams of n-6 PUFA as a single dose at 6 p.m. with their evening meal. Coagulation and fibrinolysis were evaluated in the fasting state at 8 a.m. the next morning and compared to values obtained at 8 a.m. the day before, when the participants were on their habitual diets. PAI-1 activity in plasma increased by a mean of 62% in subjects randomized to receive n-3 PUFA despite that no changes could be demonstrated in t-PA antigen levels. PAI-1 activity was unaltered in the 20 controls receiving n-6 PUFA. Plasma fibrinogen, coagulation factor VII, thrombin-antithrombin complexes and D-dimer did not significantly change after either supplement. The substantial increase in levels of PAI-1 activity in plasma after a single very high dose of n-3 PUFA may limit the usefulness of single very high doses of n-3 PUFA in acute clinical conditions.
PMID:1448789[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

75.
Ugeskr Laeger. 1992 Aug 17;154(34):2287.=[Should we eat fish oil?].=
[Article in Danish]
Dyerberg J.PMID:1413135[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

76.
Hum Genet. 1992 Jun;89(4):384-8.=Differences in apolipoprotein (a) polymorphism in west Greenland Eskimos and Caucasian Danes.=
Klausen IC, Gerdes LU, Schmidt EB, Dyerberg J, Faergeman O.===Source===
Department of Internal Medicine and Cardiology A, Aarhus County Hospital, University of Aarhus, Denmark.

Abstract

Previous studies in Greenland suggest that death rates from ischemic heart disease [IHD] are lower in Eskimos than in Danes and other Caucasian populations. This has been explained by a high intake of n-3 polyunsaturated fatty acids with beneficial effects on blood lipids and hemostasis. In other populations, lipoprotein(a) [Lp(a)] is associated with IHD, plasma concentrations of Lp(a) being genetically determined to a major extent. We have compared Lp(a) concentrations and apo(a) phenotypes in 120 Greenlandic Eskimos with those in 466 Danish men. The median Lp(a) concentration in Eskimos (8.7 mg/dl;[95% CI 6.5-10.7]) was not significantly different from that in Danes (6.3 mg/dl; [95% CI 5.2-7.0]), whereas the 90th percentile was significantly higher among Danes: 46.36 mg/dl; [95% CI 43.0-54.3] vs. 27.6 mg/dl [95% CI 20.7-36.9]. In 20% of the Danes, but in only 8% of the Eskimos (P = 0.009), the concentration of Lp(a) exceeded 30 mg/dl. The difference is probably explained by a low frequency of the low molecular weight apo(a) phenotypes among Eskimos, since the apo(a) isoforms F and B were absent, and the S1 and S2 types were present in only 3.3% of Eskimos. In contrast, these apo(a) isoforms were present in 26.6% of the Danes in either single-band or double-band phenotypes. The pattern of apo(a) polymorphism found in this study could provide part of a genetic explanation for the putative low rates of IHD in Eskimo populations.
PMID:1618487[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

77.
J Intern Med. 1992 Jun;231(6):623-5.=Plasma concentration levels of apolipoprotein A-I, apolipoprotein B and lipoprotein (a) in Greenland Inuit (Eskimos).=
Gerdes LU, Schmidt EB, Klausen IC, Kristensen SD, Ernst E, Faergeman O, Dyerberg J.===Source===
Department of Internal Medicine and Cardiology A, Aarhus Amtssygehus, University of Aarhus, Denmark.
PMID:1535650[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

78.
Diabetologia. 1992 May;35(5):447-51.=Plasma lipoproteins and renal function during simvastatin treatment in diabetic nephropathy.=
Hommel E, Andersen P, Gall MA, Nielsen F, Jensen B, Rossing P, Dyerberg J, Parving HH.===Source===
Steno Memorial and Hvidöre Hospital, Copenhagen, Denmark.

Abstract

The aim of this study was to assess the effect of simvastatin on plasma lipoproteins and renal function in hypercholesterolaemic Type 1 (insulin-dependent) diabetic patients with diabetic nephropathy. Twenty-six hypercholesterolaemic (total cholesterol greater than or equal to 5.5 mmol/l) Type 1 diabetic patients with nephropathy were enrolled in a double-blind randomized placebo-controlled study for 12 weeks. The active treatment group (n = 14) received simvastatin (10-20 mg/day) for 12 weeks while the remaining 12 patients received treatment with placebo. The results during simvastatin treatment (baseline vs 12 weeks): total cholesterol 6.6 vs 4.8 mmol/l (p less than 0.01), LDL-cholesterol 4.25 vs 2.57 mmol/l (p less than 0.01) and apolipoprotein B 1.37 vs 1.06 mmol/l (p less than 0.01). HDL-cholesterol, and apolipoprotein A-I remained unchanged. Total cholesterol, LDL-cholesterol, HDL-cholesterol, apolipoprotein A-I, apolipoprotein B remained unchanged during placebo treatment. Albuminuria measured during the simvastatin and the placebo treatment (baseline vs 12 weeks) (the data are logarithmically transformed before analysis because of their positively skewed transformation; geometric mean (x/divided by antilog SE) is indicated) was 458 (x/divided by 1.58) vs 393 (x/divided by 1.61) and 481 (x/divided by 1.62) vs 368 (x/divided by 1.78 micrograms/min (NS). Glomerular filtration rate during simvastatin and placebo treatment (baseline vs 12 weeks) was 64 vs 63 and 72 vs 74 ml.min-1.1.73 m-2, respectively. Two patients receiving simvastatin treatment were withdrawn, one due to gastrointestinal side effects and one due to myalgia.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID:1521727[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

79.
Scand J Clin Lab Invest. 1992 May;52(3):229-36.=Long-term supplementation with n-3 fatty acids, II: Effect on neutrophil and monocyte chemotaxis.=
Schmidt EB, Varming K, Pedersen JO, Lervang HH, Grunnet N, Jersild C, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

The effect of a daily supplement with 4 g of n-3 polyunsaturated fatty acids (PUFA) for 9 months to 24 healthy volunteers on neutrophil and monocyte chemotaxis was studied using the under-agarose technique. Autologous serum and n-formyl-methionyl-leucyl-phenylalanine were used as chemoattractants. The effect after 9 months of supplementation with n-3 PUFA was also compared to results after short-term supplementation with n-3 PUFA for 6 weeks. Monocyte chemotaxis was reduced after 9 months of supplementation with n-3 PUFA to the same extent as after 6 weeks supplement. Neutrophil-directed migration towards chemoattractants was reduced after 9 months on fish oil, and this decrease was significantly greater than the decrease obtained after 6 weeks of supplementation. The spontaneous migration of neutrophils was significantly attenuated after 9 months compared to baseline and to 6 weeks. These findings lend support to a role for n-3 PUFA in the management of chronic inflammatory and atherosclerotic vascular diseases.
PMID:1411255[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

80.
Scand J Clin Lab Invest. 1992 May;52(3):221-8.=Long-term supplementation with n-3 fatty acids, I: Effect on blood lipids, haemostasis and blood pressure.=
Schmidt EB, Lervang HH, Varming K, Madsen P, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

The effect of dietary supplementation with 4 g of n-3 polyunsaturated fatty acids (PUFA) daily for 9 months on blood pressure, plasma lipids and lipoproteins, platelet function, coagulation and fibrinolysis was studied in 24 healthy volunteers. Each variable was determined before, after 6 weeks and 9 months of supplementation with n-3 PUFA, and 3 months after the supplementation period had ended. Systolic and diastolic blood pressure declined after intake of n-3 PUFAs. Plasma triglycerides were reduced, and there was a trend towards an increase in HDL-cholesterol after 9 months of supplementation, while total cholesterol, LDL-cholesterol and apolipoproteins A1 and B were unaltered. The bleeding time was increased, and plasma levels of von Willebrand factor decreased after 9 months supplementation with n-3 PUFA. Fibrinogen levels increased, while fibrinolysis was reduced after 9 months supplementation with n-3 PUFA. Overall, no clear benefit on lipid pattern and haemostasis was achieved with respect to development of coronary heart disease.
PMID:1411254[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

81.
Ann Nutr Metab. 1992;36(5-6):283-7.=n-3 polyunsaturated fatty acid supplementation (Pikasol) in men with moderate and severe hypertriglyceridaemia: a dose-response study.=
Schmidt EB, Varming K, Svaneborg N, Dyerberg J.===Source===
Department of Medicine, Aalborg Hospital, Denmark.

Abstract

The effect of n-3 fatty acids in 11 men with hypertriglyceridaemia was investigated. The subjects were given daily supplements with three different doses of n-3 fatty acids for 8-week periods. The supplements given were 2, 4 and 9 g of n-3 fatty acids/day, respectively. Total cholesterol, triglycerides and the ratio of total cholesterol to HDL-cholesterol significantly decreased with all three doses in a dose-dependent way. HDL-cholesterol increased in a dose-dependent fashion, while apolipoproteins A1 and B were unaltered by the supplements apart from a small increase in apolipoprotein A1 after the lowest dose of n-3 fatty acids. The greatest effect was observed after 2 g of n-3 fatty acids/day.
PMID:1492755[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

82.
Scand J Immunol. 1991 Oct;34(4):399-410.=Dietary supplementation with omega-3-polyunsaturated fatty acids decreases mononuclear cell proliferation and interleukin-1 beta content but not monokine secretion in healthy and insulin-dependent diabetic individuals.=
Mølvig J, Pociot F, Worsaae H, Wogensen LD, Baek L, Christensen P, Mandrup-Poulsen T, Andersen K, Madsen P,Dyerberg J, et al.===Source===
Steno Memorial Hospital, Hagedorn Research Laboratory, Gentofte, Denmark.

Abstract

The effects of dietary supplementation with omega-3-polyunsaturated fatty acids (omega-3-PUFA) on the proliferative response of PBMC and on the secretion of monokines and arachidonic acid metabolites from PBMC and monocytes (Mo) from healthy subjects and patients with recent-onset insulin-dependent diabetes mellitus (IDDM) were examined. Three groups of eight to nine healthy individuals were randomized to either 2.0 g/day or 4.0 g/day of omega-3-PUFA devoid of vitamins A and D, or an isocaloric amount of placebo. Furthermore, eight patients with recent-onset IDDM received 4.0 g/day of omega-3-PUFA. IL-1 beta production and TNF-alpha secretion was determined before and after 7 weeks of treatment, and 10 weeks after withdrawal of treatment. Significant increases in platelet and PBMC membrane eicosapentaenoic acid was found in omega-3-PUFA-treated individuals. omega-3-PUFA treatment significantly reduced the content of IL-1 beta in lysates of PBMC, but did not affect PBMC or Mo secretion of IL-1 beta, TNF-alpha or prostaglandin E2 (PGE2) or PBMC leukotriene B4 (LTB4) secretion in healthy subjects or in IDDM patients. A significant inhibition of the PHA-stimulated, but not the spontaneous or PPD-stimulated, proliferative response of PBMC was observed in healthy and diabetic subjects treated with omega-3-PUFA. No correlation was found between PHA-stimulated PBMC proliferation and PBMC secretion of TNF-alpha and IL-1 beta. There were no significant differences in the spontaneous or the PPD- or PHA-stimulated proliferative responses of PBMC between diabetic and healthy individuals at entry. We conclude that although dietary supplementation with 4.0 g/day of omega-3-PUFA inhibits the proliferation of PBMC and reduces IL-1 beta immunoreactivity in PBMC and Mo, it does not alter monokine, PGE2 or LTB4, secretion in healthy or IDDM subjects.
PMID:1656517[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

83.
Clin Chim Acta. 1991 May 15;198(3):271-7.=The effect of n-3 polyunsaturated fatty acids on Lp(a).=
Schmidt EB, Klausen IC, Kristensen SD, Lervang HH, Faergeman O, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
PMID:1832343[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

84.
Arterioscler Thromb. 1991 Mar-Apr;11(2):429-35.=n-3 fatty acids and leukocyte chemotaxis. Effects in hyperlipidemia and dose-response studies in healthy men.=
Schmidt EB, Pedersen JO, Varming K, Ernst E, Jersild C, Grunnet N, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

Dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFAs) has been shown to inhibit neutrophil and monocyte chemotaxis in healthy subjects and, with respect to neutrophils, also in various patient groups. We studied the effect of dietary supplementation with n-3 PUFAs on monocyte and neutrophil chemotaxis in patients with hyperlipidemia. Chemotaxis was investigated with the under-agarose assay, using autologous serum and N-formyl-methionyl-leucyl-phenylalanine as chemoattractants. The patients were examined before and after 6 weeks of supplementation with 6 g n-3 PUFAs daily. Monocyte chemotaxis was reduced after n-3 PUFA supplementation in type IIa patients but was unaffected in patients with type IV hyperlipidemia. Furthermore, monocyte chemotaxis was increased in untreated type IIa patients compared with normocholesterolemic controls. We also studied the dose-response effects of n-3 PUFAs on monocyte and neutrophil chemotaxis in healthy men given 1.3, 4, and 9 g n-3 PUFAs daily for 6-week periods. Monocyte and neutrophil chemotaxis was reduced after n-3 PUFA supplements in a dose-dependent fashion, with the majority of the effect observed after the low dose. These results lend support to the notion of an antiatherosclerotic effect of n-3 PUFAs and may provide an explanation for the hitherto-unexplained effect of low doses of n-3 PUFAs in coronary heart disease.
PMID:1998659[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

85.
Ugeskr Laeger. 1991 Jan 28;153(5):355-60.=[Standardized prothrombin time determinations and optimal anticoagulant therapy].=
[Article in Danish]
Jespersen J, Hansen MS, Dyerberg J, Ingerslev J, Jensen G, Jørgensen M, Laursen B, Nielsen JD, Svendsen TL.===Source===
Sektionen for haemostase og trombose under Dansk Selskab for Klinisk Kemi, Dansk Selskab for Intern Medicin og Dansk Selskab for Klinisk Immunologi.

Abstract

WHO and other international organizations have recommended the introduction of a standardized prothrombin time determination. This would allow a universal scale for the intensity of oral anticoagulation therapy to be used. A prerequisite is the use of thromboplastin, calibrated against the international reference thromboplastin, standardized methodology etc. This permits every prothrombin time determination to be expressed as International Normalized Ratio (INR). The introduction of INR facilitates the implementation of optimal oral anticoagulation as defined by larged international studies.
PMID:1994562[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

86.
World Rev Nutr Diet. 1991;66:16-9.=Conference summary and future directions.=
Dyerberg J.===Source===
Medi-Lab a.s., Copenhagen, Denmark.
PMID:2053335[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

87.
Ugeskr Laeger. 1990 Oct 15;152(42):3088-9.=[Human milk substitutes based on cow's milk].=
[Article in Danish]
Dyerberg J.PMID:2238188[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms===

88.
Clin Chim Acta. 1990 Jul;189(1):25-32.=The effect of n-3 polyunsaturated fatty acids on lipids, platelet function, coagulation, fibrinolysis and monocyte chemotaxis in patients with hypertension.=
Schmidt EB, Nielsen LK, Pedersen JO, Kornerup HJ, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

We have studied the effect of dietary supplementation with 4 g of n-3 polyunsaturated fatty acids (n-3 PUFA) daily for 6 wk on plasma lipids, haemostasis and monocyte chemotaxis in 10 patients with untreated hypertension. Total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides did not change, but the ratio of total to HDL-cholesterol was significantly reduced after the fish oil supplement. Platelet function was unaltered by intake of n-3. Plasma fibrinogen and fibronectin decreased after supplementation with n-3 PUFA, while the effects on fibrinolysis were equivocal. Monocyte chemotaxis was reduced by the supplement. These data lend support to a role for an increased intake of n-3 PUFA in the management of patients with hypertension.
PMID:2383918[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

89.
Ugeskr Laeger. 1990 May 14;152(20):1434-7.=[Recommendations for clinical-chemical departments: lipid-lipoprotein analysis].=
[Article in Danish]
Dyerberg J, Stender S, Andersen GE, Faergeman O, Haghfelt T, Hviid T, Jensen TJ, Leth A, Sigurd B, Skovby F.===Source===
Medicinsk Laboratorium a.s., København.

Abstract

The section for preventive cardiology within the Danish Society for Cardiology has established a lipid group with representatives from The Danish Society for Clinical Chemistry, The Danish Society for Internal Medicine, The Danish Society for Cardiology, The Danish Society of Hypertension, The Danish College of General Practitioners, and The Danish Paediatric Society. The lipid group has elaborated recommendations for clinical chemical departments regarding lipid and lipoprotein analyses. The group suggests that doctors ordering lipid and lipoprotein analyses are offered the following: S-Cholesterol (total), substance conc., (fPt)S-Triglycerides, substance conc., S-HDL-cholesterol, substance conc., and (fPt)S-LDL-cholesterol, substance conc. (calculated). It is recommended that the biological variation be minimized by sampling in a sitting position after a 15 minutes' rest and by basing the clinical decision on a minimum of 2-3 determinations with an interval of about one month. The analytical variations should be reduced to below 3% (calculated as the variation coefficient), and it is recommended that laboratories participate in external quality control systems at least four times annually by reporting at least two human reference materials with different concentrations. As the use of reference intervals dependent on age and sex, based on random samplings of the background population, are less informative, it is recommended to refer to cutoff values for the clinical decision. The following cutoff values are recommended: S-Cholesterol (total), substance conc.: 6 mmol/l, (fPt)S-Triglycerides, substance conc.; 2.5 mmol/l, S-HDL-cholesterol, substance conc.: 0.9 mmol/l (fPt)-LDL-cholesterol, substance conc. (calculated): 4.5 mmol/l.(ABSTRACT TRUNCATED AT 250 WORDS)

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface control[Age and cholesterol recommendations]. [Ugeskr Laeger. 1995]

PMID:2343500[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

90.
Prostaglandins Leukot Essent Fatty Acids. 1990 May;40(1):39-43.=Plasma 6-keto-PGF1 alpha, thromboxane B2 and PGE2 during diabetic ketoacidosis.=
Mourits-Andersen T, Jensen IW, Nielsen LK, Nielsen GL, Dyerberg J, Ditzel J.===Source===
Department of Medicine, Aalborg Hospital, Denmark.

Abstract

In 10 patients admitted to hospital with diabetic ketoacidosis plasma prostanoids 6-keto-PGF alpha, thromboxane B2 and PGE2 were studied before treatment and following recovery. During ketoacidosis the median plasma 6-keto-PGF1 alpha and PGE2 were significantly increased compared to those of a normal reference group: 5.2 pg/ml and 3.9 pg/ml versus 1.7 pg/ml and 0.4 pg/ml (p less than 0.01 and p less than 0.05). In response to therapy both prostanoids decreased significantly towards a normal level, 6-keto-PGF1 alpha: 0.5 pg/ml p less than 0.01 and PGE2: 0.08 p less than 0.05 respectively. The changes in plasma 6-keto-PGF1 alpha were negatively correlated to changes in pH, rho: -0.7788 p = 0.0135, whereas the changes in PGE2 were positively correlated to serum creatinine at admittance, rho: 0.6976, p = 0.0368 and to the amount of intravenous fluid and insulin used during treatment, rho: 0.7500 p = 0.0126 and rho: 0.8424, p = 0.0023 respectively. Plasma thromboxane B2 concentrations were not elevated and did not change after treatment of the ketoacidosis.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlPlasma 6-keto-PGF1 alpha, thromboxane B2 and PGE2 during diabetic ketoacidosis. [Prostaglandins Leukot Essent Fatty Acids. 1990]

PMID:2119041[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

91.
Ugeskr Laeger. 1990 Apr 30;152(18):1290-3.=[Fish oil products. Contents of n-3 fatty acids and oxidative break-down products].=
[Article in Danish]
Madsen PH, Dyerberg J.===Source===
Aalborg Sygehus, klinisk-kemisk afdeling, København.

Abstract

Twenty-five fish oil products commercially available in Denmark were examined for their content of n-3 fatty acids. The magnitude of n-3 fatty acid intake was calculated when the dosage recommended by the manufacturers was adhered to. Where the majority of the products were concerned, the intake was much less than the approximately 2 g daily which produces demonstrable effect. Where isolated preparations are concerned, the intake is so limited that this has probably no value. The content of oxidation products in the preparations was also investigated. Compared with the quantity of oxidation products from other sources, the content in the preparations examined is of minor significance.
PMID:2343482[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

92.
J Diabet Complications. 1990 Apr-Jun;4(2):68-9.=General experience with fish oil treatment.=
Dyerberg J.PMID:2145304[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

93.
Thromb Haemost. 1990 Feb 19;63(1):1-5.=Dose-response studies on the effect of n-3 polyunsaturated fatty acids on lipids and haemostasis.=
Schmidt EB, Varming K, Ernst E, Madsen P, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

We have studied the dose-response effects of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA's) on lipids and haemostasis. Ten healthy males were each given 1.3 g, 4 g or 9 g of n-3 PUFA's daily for 6-week periods. Bleeding time, HDL-cholesterol and plasminogen activator inhibitor increased with the dose of n-3 PUFA. Plasma fibrinogen and triglyceride levels were reduced in a dose-dependent fashion. After ingestion of 1.3 g of n-3 PUFA's plasma fibrinogen decreased from 9 to 7 mumol/l and HDL-cholesterol increased from 1.2 to 1.3 mmol/l. The bleeding time was prolonged from 5 to 6.5 min while triglyceride levels decreased from 1.2 to 0.9 mmol/l after ingestion of 4 g of n-3 PUFA's. Dietary supplementation with the highest daily dose (9 g) reduced plasma levels of triglycerides, fibrinogen and von Willebrand factor, while bleeding time, plasminogen activator antigen, plasminogen activator inhibitor and the ratio of HDL-cholesterol to total cholesterol increased.

Comment in

• The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
  Destroy user interface controlDose-response studies of platelet aggregation and bleeding time during eicosapentaenoic acid intake.[Thromb Haemost. 1991]

PMID:2339345[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

94.
Scand J Gastroenterol. 1990 Jan;25(1):40-4.=Plasma prekallikrein as a prognostic indicator in chronic liver insufficiency.=
Agnholt J, Mikkelsen JH, i Bud M, Møller-Petersen J, Rasmussen SN, Dyerberg J.===Source===
Dept. of Medical Gastroenterology, Aalborg Hospital, Denmark.

Abstract

The prognostic value of plasma prekallikrein activity, prothrombin time, and serum albumin with regard to survival in chronic liver insufficiency was evaluated in 21 consecutive patients. Twenty patients had liver cirrhosis, and one patient had malignant liver disease (hepatocellular carcinoma). Eight patients died between 4 and 43 days after the time of blood sampling. These patients had a prekallikrein value less than 0.42. There were no overlapping prekallikrein values between patients who died and patients who survived (overlap index 0; p less than 0.001). Overlap index for prothrombin time was 0.35 (p less than 0.02), and for serum albumin 0.34 (p less than 0.02). In conclusion, plasma prekallikrein seems to indicate whether death is imminent in patients with liver insufficiency due to cirrhosis. Longitudinal studies of prekallikrein activity in different subgroups of patients with chronic and acute liver disease are recommended.
PMID:2154845[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

95.
Thromb Res. 1989 Nov 15;56(4):553-8.=Studies on coagulation and fibrinolysis in Greenland Eskimos.=
Schmidt EB, Sørensen S, Ernst E, Kristensen SD, Pedersen JO, Dyerberg J.===Source===
Department of Clinical Chemistry and Clinical Immunology, Aalborg Hospital, Denmark.
PMID:2609292[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

96.
Thromb Haemost. 1989 Sep 29;62(2):797-801.=The effect of n-3 fatty acids on lipids and haemostasis in patients with type IIa and type IV hyperlipidaemia.=
Schmidt EB, Ernst E, Varming K, Pedersen JO, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

Plasma lipids and haemostasis were investigated in 17 patients with hyperlipidaemia before and after 6 weeks supplementation with 6 g n-3 fatty acids. Nine of the patients had type IIa and 8 had type IV hyperlipidaemia. No effect on plasma cholesterol, LDL- or HDL-cholesterol were seen, but plasma triglycerides decreased after n-3 supplementation. Apolipoprotein B increased and apolipoprotein A1 decreased after the oil supplement. The bleeding time was prolonged, but platelet aggregation was unaltered by n-3 fatty acids. Protein C activity increased in type IIa and decreased in type IV after the supplement. Fibrinolysis was markedly depressed while von Willebrand factor antigen was reduced after intake of n-3 fatty acids.
PMID:2814927[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

97.
Sygeplejersken. 1989 Sep 20;89(38):20-3.=[Fish and fish oil].=
[Article in Danish]
Dyerberg J.PMID:2814881[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

98.
J Intern Med. 1989 Aug;226(2):101-5.=Protein C in renal allotransplantation during the perioperative period.=
Sørensen PJ, Nielsen AH, Knudsen F, Schmitz O, Dyerberg J.===Source===
Department of Nephrology, Aalborg Hospital, Denmark.

Abstract

Protein C activity, both coagulant and amidolytic, as well as antigen level were studied during the perioperative period in 40 renal transplants recipients and 21 healthy controls. At transplantations the protein C coagulant activity was significantly lower in the patients than in the normal controls, and further decreased in the patients during the first week after transplantation, whereas the amidolytic activity of protein C was normal and the protein C antigen level was elevated. In the patients with established kidney function, protein C coagulant activity was higher than in patients with impaired graft function. Furthermore, it seems that the protein C coagulant activity was closely related to changes in graft function in the 11 patients with graft rejection episodes. The low protein C coagulant activity following renal transplantation could be a contributing factor to thromboembolic complications.
PMID:2671246[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

99.
Thromb Res. 1989 May 15;54(4):301-10.=Protein C assays in uremia.=
Sørensen PJ, Knudsen F, Nielsen AH, Dyerberg J.===Source===
Department of Medicine, Nephrology C and Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

Protein C was determined in 42 patients with terminal uremia and 20 healthy controls in three different ways 1) anticoagulant activity 2) amidolytic activity 3) antigen level. Protein C anticoagulant activity was markedly decreased in uremia, but was partly normalized during hemodialysis treatment, whereas the amidolytic activity and antigen level of protein C were normal and without changes during dialysis. The activities and antigen levels of factor II and X were normal before and after hemodialysis. In anticoagulated patients we found a good correlation between prothrombin levels and protein C levels determined with three different assays. We did not find any evidence for a defect carboxylation of protein C as the cause for the defective protein C in uremia. The BaCl2 precipitation in the Protein C anticoagulant assay was incomplete both in uremia and in controls but without differences between the two groups. In vitro addition of urea and creatinine did not decrease protein C activity. The cause of the defective protein C in uremia is still not known but it might contribute to thromboembolic complications.
PMID:2763269[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

100.
Atherosclerosis. 1989 May;77(1):53-7.=Cod liver oil inhibits neutrophil and monocyte chemotaxis in healthy males.=
Schmidt EB, Pedersen JO, Ekelund S, Grunnet N, Jersild C, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

Epidemiological evidence suggests a reduced rate of chronic inflammatory diseases and ischaemic heart disease in populations with a high consumption of fish. This has been ascribed to the high content in sea food of polyunsaturated fatty acids (PUFAs), belonging to the n – 3 family. We have studied neutrophil and monocyte chemotaxis in 12 healthy males before and after 6 weeks supplementation with cod liver oil, corresponding to 5.3 g n – 3 PUFAs daily. Neutrophil and monocyte chemotaxis were investigated using the under agarose technique with N-formyl-methionyl-leucyl-phenylalanine (N-FMLP) and autologous serum as chemoattractants. Neutrophil chemotaxis towards both chemoattractants and monocyte chemotaxis towards N-FMLP were significantly reduced after supplementation with cod liver oil.
PMID:2719762[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

101.
Wien Klin Wochenschr. 1989 Apr 14;101(8):277-82.=n-3 fatty acids and cardiovascular disease–observations generated by studies in Greenland Eskimos.=
Dyerberg J, Schmidt EB.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

Polyunsaturated fatty acids of the n-3 type (n-3 PUFAs) may offer some protection against ischaemic heart disease (IHD). Part of the evidence has been derived from our investigations on Greenland Eskimos. Through six expeditions to Greenland, we have studied Eskimos living on their traditional sea diet. We found favourable changes in lipids and lipoproteins, together with a reduced platelet reactivity in the Eskimos – findings of importance for their low incidence of IHD. In this survey we intend to review studies on the effects of an increased intake of n-3 PUFAs, focusing on lipids and platelets. We conclude that beneficial changes in general have been obtained. However, individual patients and patient groups likely to profit from supplementation with n-3 PUFAs need to be further defined. The optimum dose needs to be established, and the effect and safety to be documented by highly needed long term studies.
PMID:2658332[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

102.
Arctic Med Res. 1989 Apr;48(2):47-54.=Coronary heart disease in Greenland Inuit: a paradox. Implications for western diet patterns.=
Dyerberg J.===Abstract===
Epidemiologic examinations of Greenland Inuit have disclosed a connection between high seafood intake containing a high level of n-3 polyunsaturated fatty acids (PUFAs) and a low coronary heart disease (CHD) morbidity. Other epidemiologic studies have confirmed this interrelation, and a biological substrate for a causal relationship has been established. This includes a lipid lowering effect of n-3 PUFAs and a modulatory effect on eicosanoid metabolism, shifting platelet vessel wall balance in an antithrombotic direction. Other metabolic effects of n-3 PUFAs are an altered inflammatory response to proinflammatory stimuli and a modest hypotensive effect. These findings create a basis for controlled clinical studies and justify, in the author's opinion, both a mass strategy of advocating that a well-balanced diet should include a higher use of seafood in Western diets, and a more intensive recommendation of n-3 PUFAs in certain high-risk patients with a heterogeneous risk-factor profile. Among these, patients with essential hypertension and patients undergoing reconstructive coronary intervention are obvious candidates. A major outcome of the research, stemming from the epidemiological studies, is establishment of the fact that separate attention should be paid to both the n-6 and the n-3 fatty acids.
PMID:2736000[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

103.
Ugeskr Laeger. 1989 Jan 9;151(2):69-70.=[Fish oils].=
[Article in Danish]
Dyerberg J.PMID:2911900[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

104.
Blood Purif. 1989;7(4):230-2.=Functional impairment of protein C activity during haemodialysis–a new mechanism of extracorporeal thrombogenesis.=
Knudsen F, Sørensen J, Nielsen AH, Dyerberg J.PMID:2775516[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

105.
Blood Purif. 1989;7(4):218-22.=Further investigations of the defective protein C in hemodialysis, hemofiltration and continuous ambulatory peritoneal dialysis.=
Sørensen PJ, Nielsen AH, Knudsen F, Dyerberg J.===Source===
Department of Medicine, Aalborg Hospital, Denmark.

Abstract

Protein C activity was determined in patients with terminal renal failure treated in three different ways: hemodialysis (n = 20), hemofiltration (n = 7) and continuous ambulatory peritoneal dialysis (n = 7). The protein C activity was decreased in terminal uremia, independent of the kidney replacement therapy employed, compared with 21 normal controls. In the hemodialysis patients protein C activity increased significantly during a hemodialysis treatment, whereas hemofiltration treatment normalized the depressed protein C activity. In vitro experiments with dialysis and with inhibition of normal plasma with ultrafiltrates could not reveal the presence of an inhibitor of protein C in uremic plasma.
PMID:2775514[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

106.
J Intern Med Suppl. 1989;731:201-6.=The effect of n-3 polyunsaturated fatty acids on lipids, haemostasis, neutrophil and monocyte chemotaxis in insulin-dependent diabetes mellitus.=
Schmidt EB, Sørensen PJ, Pedersen JO, Jersild C, Ditzel J, Grunnet N, Dyerberg J.===Source===
Department of Medicine, Aalborg Hospital, Denmark.

Abstract

Insulin-dependent diabetes mellitus (IDDM) is associated with an increased risk of coronary artery disease (CAD). There is some evidence that polyunsaturated fatty acids of the marine n-3 type (n-3 PUFA's) may offer protection against CAD. We have studied the effect of short-term dietary supplementation with n-3 PUFAs on lipids, haemostasis, neutrophil and monocyte chemotaxis in 10 patients with IDDM. The patients were given 4 g daily of n-3 PUFAs (fish oil) for 6 weeks and were investigated before and after the supplement. No significant effects on platelets or haemostasis were observed. High density lipoprotein (HDL)-cholesterol significantly increased, and triglycerides and the ratio of total cholesterol to HDL-cholesterol significantly decreased. Monocyte chemotaxis was unaltered, while neutrophil chemotaxis significantly increased after fish oil. The finding of an improvement in neutrophil chemotaxis after supplementation with n-3 PUFAs to patients with IDDM needs to be confirmed in future studies.
PMID:2706043[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

107.
J Intern Med Suppl. 1989;731:1-3.=n-3 fatty acids in health and disease. Introduction.=
Nordøy A, Dyerberg J.===Source===
Department of Medicine, University of Tromsø, Norway.
PMID:2706037[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

108.
J Intern Med Suppl. 1989;731:151-8.=n-3 fatty acids and leucocytes.=
Schmidt EB, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

The evidence presented here favours the view that dietary supplementation with n-3 fatty acids results in attenuated activity of pro-inflammatory leukotrienes formed through the 5-lipoxygenase pathway in leucocytes. Neutrophil and monocyte chemotaxis seem to decrease, although this may depend on the patient groups studied. n-3 fatty acids increase the proliferative responses of lymphocytes. It is less clear, whether n-3 fatty acids affect other parts of leucocyte function. The possible value of n-3 PUFAs in inflammatory diseases in humans needs to be documented in carefully conducted clinical trials, which also should look carefully for possible side effects. However, the results obtained so far have been promising. The modulating effect of n-3 fatty acids on leucocyte activity-together with their other effects-could be favourable in atherosclerosis and coronary disease.
PMID:2650691[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

109.
J Intern Med Suppl. 1989;731:141-50.=Dietary supplementation with n-3 polyunsaturated fatty acids and human platelet function: a review with particular emphasis on implications for cardiovascular disease.=
Kristensen SD, Schmidt EB, Dyerberg J.===Source===
University Department of Medicine and Cardiology, County Hospital of Aarhus, Denmark.

Abstract

The low incidence of myocardial infarction in Greenland Eskimos may be due to their intake of marine food with a high content of n-3 polyunsaturated fatty acids (PUFAs). In Eskimos the platelet count is lowered, the platelet aggregation is inhibited, the bleeding time is prolonged and the ratio between proaggregatory thromboxanes and anti-aggregatory prostacyclins is decreased, when compared to age- and sex-matched Danes. In this review, studies evaluating the effect of a fish diet or fish-oil supplementation on human platelet function are summarized. Most studies have demonstrated that supplementation with n-3 PUFAs can cause inhibition of platelet behaviour. The optimal dose of n-3 PUFAs and the patient groups most likely to profit from supplementation need to be defined. The safety and the clinical effect of the supplementation should be investigated in long-term studies.
PMID:2650690[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

110.
J Intern Med Suppl. 1989;731:237-8.=Prospectives on n-3 fatty acids in medical research.=
Dyerberg J, Nordøy A.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
PMID:2539834[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

111.
Int J Epidemiol. 1988 Sep;17(3):514-9.=Mortality from ischaemic heart disease and cerebrovascular disease in Greenland.=
Bjerregaard P, Dyerberg J.===Source===
Danish Institute for Clinical Epidemiology, Copenhagen, Denmark.

Abstract

Mortality 1968-83 from Ischaemic Heart Disease (IHD) and Cerebrovascular Disease (CD) was studied in native Greenlanders. Mortality from IHD was lower in Greenland than in Denmark for both males and females and especially low in Greenlandic settlements. IHD mortality decreased during the period. Mortality from CD was higher in Greenland than in Denmark with no certain time trend. Living conditions, of which a high intake of seafood may be a key factor, and/or a genetic predisposition seem to protect Greenlanders from IHD and to predispose them to CD.

PIP:

Mortality from ischemic heart disease and cerebrovascular disease among native Greenlanders is studied and compared with sex-specific rates in Denmark. Living conditions, nutrition, and genetic predisposition are considered as factors influencing these causes of death.
PMID:3209329[PubMed – indexed for MEDLINE] Related citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms===

112.
Scand J Clin Lab Invest. 1988 Sep;48(5):469-73.=Antithrombin III and protein C in stable angina pectoris–influence of dietary supplementation with polyunsaturated fatty acids.=
Schmidt EB, Kristensen SD, Sørensen PJ, Dyerberg J.===Source===
Department of Clinical Chemistry and Cardiology, Aalborg Hospital, Denmark.

Abstract

The effect on plasma antithrombin III (AT III) and protein C on a supplement with polyunsaturated fatty acids (PUFA's) was investigated in a double-blind study in 36 patients with stable angina pectoris. All participants were given a supplement to their normal diets of vegetable oil (4.8 g n-6 PUFA's) for 4 weeks and were then randomized to the same oil or to fish oil (4.8 g n-3 PUFA's) for 12 weeks. Both oil supplements resulted in a statistically significant decrease in AT III activity, but there were no differences between the two different types of PUFA's. Antithrombin III antigen, protein C antigen or activity did not change significantly after either oil supplement. The background and significance for the decrease in antithrombin III activity induced by n-3 and n-6 PUFA's in patients with ischaemic heart disease is unknown.
PMID:3060987[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

113.
Lancet. 1988 Aug 27;2(8609):514.=Fish oil and ischaemic heart disease in Greenland.=
Bjerregaard P, Dyerberg J.PMID:2900440[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

114.
Acta Med Scand. 1988;224(4):375-80.=Protein C in acute renal failure.=
Sørensen PJ, Knudsen F, Nielsen AH, Dyerberg J.===Source===
Department of Nephrology, Aalborg Hospital, Denmark.

Abstract

In 16 patients with acute renal failure we studied protein C activity, both coagulant and amidolytic, as well as protein C antigen level. Protein C coagulant activity was markedly decreased in acute renal failure. Furthermore, changes in kidney function were paralleled by alterations in protein C coagulant activity. The amidolytic activity and antigen level of protein C were normal in most cases, and the changes observed in a few patients seem clearly related to changes in liver function. This defective protein C could contribute to the thrombotic tendency reported in patients with acute renal failure.
PMID:3188987[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

115.
Artery. 1988;15(6):316-29.=The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris.=
Schmidt EB, Kristensen SD, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Hospital, Denmark.

Abstract

The effect of fish oil on lipids, coagulation and fibrinolysis was investigated in patients with stable angina pectoris. The patients were given a daily supplement of 4.5 g n-6 polyunsaturated fatty acids (PUFA's) for 4 weeks and were then randomized to the same oil or to fish oil (4.5 g n-3 PUFA's) for 12 weeks. Blood samples were taken before and after 16 weeks of oil supplementation. Lipids, coagulation and fibrinolysis were measured in 14 patients treated with fish oil. There was a significant decrease in triglycerides and very low density lipoproteins but unexpectedly a significant increase in total cholesterol from 5.9 to 6.7 mmol/l after fish oil. The fibrinolytic activity at rest determined by the fibrin plate method showed a decrease after fish oil. Other measurements did not reveal any statistically significant changes. These finding necessitate caution with uncontrolled supplementation with fish oil in patients with stable angina pectoris.
PMID:3178506[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

116.
Nephron. 1988;49(4):335-6.=Inhibitors of coagulation in terminal renal failure and during hemodialysis.=
Knudsen F, Sørensen PJ, Nielsen AH, Dyerberg J.===Source===
Department of Nephrology, Aalborg Hospital, Denmark.
PMID:3412549[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

117.
Nord Med. 1988;103(5):161-5, 188.=[n-3 polyunsaturated fatty acids and their possible role in the prevention of diseases].=
[Article in Danish]
Dyerberg J.PMID:3375046[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

118.
Scand J Urol Nephrol. 1988;22(1):59-63.=Haemostatic aspects of renal transplantation.=
Sørensen PJ, Schmidt EB, Knudsen F, Nielsen AH, Kristensen SD, Dyerberg J, Kornerup HJ.===Source===
Department of Nephrology, Aalborg Hospital, Denmark.

Abstract

Platelet function and protein C activity and antigen level was studied in 31 renal transplant recipients and 10 healthy controls. The patients were divided into three groups: (I) cyclosporin treated, (II) azathioprine treated, and (III) azathioprine treated patients with chronic rejection. The platelet function in the renal transplant patients was normal and there was no difference between groups I and II. The specific activity of protein C was decreased in patients after renal transplantation and decreasing protein C activity and progressive renal failure was found to be positively correlated in the azathioprine treated groups.
PMID:3291092[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

119.
Diabetologia. 1987 Jul;30(7):460-3.=Plasma 6-keto-PGF1 alpha, thromboxane B2 and PGE2 in type 1 (insulin-dependent) diabetic patients during exercise.=
Mourits-Andersen T, Jensen IW, Jensen PN, Ditzel J, Dyerberg J.===Source===
Department of Clinical Chemistry, Aalborg Sygehus Nord, Denmark.

Abstract

The capacity of prostacyclin production determined as plasma 6-keto-PGF1 alpha was investigated in 12 type 1 (insulin-dependent) diabetic patients with a median duration of diabetes of 14 years during ordinary metabolic control. Using high pressure liquid chromatography preceding radioimmunoassay, the plasma concentration of 6-keto-PGF1 alpha, the stable metabolite of prostacyclin, was determined at rest and after a standardised bicycle exercise test. The plasma 6-keto-PGF1 alpha in diabetic patients at rest did not differ from that of 25 healthy volunteers; 2.9 pg/ml (range less than 0.2-15.3) versus 1.7 pg/ml (range less than 0.2-16.6). During the exercise test plasma 6-keto-PGF1 alpha increased significantly in the diabetic patients as well as in the control group (p less than 0.05). The increment of 6-keto-PGF1 alpha in the diabetic patients was neither related to the metabolic regulation, duration of diabetes nor to changes in platelet volume, platelet number or the production of thromboxane B2 and prostaglandin E2. Our results do not support the hypothesis that Type 1 diabetic patients have a decreased capacity of prostanoid production, as suggested from in vitro studies.
PMID:3478279[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

120.
Ugeskr Laeger. 1987 Jun 22;149(26):1723-8.=[N-3 poly-unsaturated fatty acids and their possible role in the prevention of disease. A review with special attention to ischemic heart disease].=
[Article in Danish]
Dyerberg J.PMID:3299956[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

121.
Lancet. 1987 Mar 14;1(8533):633.=Fatty acid pattern and ischaemic heart disease.=
Bang HO, Dyerberg J.PMID:2881171[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

122.
Atherosclerosis. 1987 Mar;64(1):13-9.=Fish oil in angina pectoris.=
Kristensen SD, Schmidt EB, Andersen HR, Dyerberg J.===Abstract===
The effect of 12 weeks supplementation with fish oil on the number of anginal attacks and consumption of glyceryltrinitrate in 36 patients with stable angina pectoris was evaluated in a clinically controlled trial using a vegetable oil as placebo. Fish oil caused a decrease in frequency of angina, but was not significantly superior to placebo. However, due to the small sample size and a high spontaneous variation in number of anginal attacks, a risk of up to 50% of overlooking a 30% reduction in anginal attacks could be estimated. A significant inhibition of the epinephrine-induced platelet aggregation and a significant increase in intraplatelet cyclic AMP were induced by fish oil.
PMID:3109445[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

123.
Blood Purif. 1987;5(1):29-32.=Defective protein C in uraemia.=
Sørensen PJ, Nielsen AH, Knudsen F, Dyerberg J.===Abstract===
Protein C activity and antigen levels were determined in 10 haemodialysis patients and 10 healthy controls matched for age and sex. Markedly decreased protein C activity was found whereas protein C antigen level was normal in uraemics. This finding, together with our recent observation that plasma protein C activity is partly normalised during haemodialysis, lead us to suggest the presence of one or more inhibitors of protein C activity in plasma from patients with uraemia.
PMID:3790269[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

124.
Prostaglandins. 1986 Aug;32(2):235-41.=The prostacyclin/thromboxane balance is favourably shifted in Greenland Eskimos.=
Fischer S, Weber PC, Dyerberg J.===Abstract===
The rare incidence of cardiovascular disease in Eskimos has been ascribed to their diet rich in eicosapentaenoic acid (EPA, C20:5n-3) and hence a possible formation of trienoic prostanoids. In this study we compare endogenous formation of prostacyclin (PGI), which is formed by the endothelial cell, and thromboxane (TXA), which is formed by platelets in 20 Eskimos and 20 age and sex matched Danish controls by measurement of the main urinary metabolites. Considerable formation of bioactive PGI3 from dietary EPA was shown in Eskimos, which was barely detectable in the controls. Furthermore synthesis of PGI2 was significantly higher in Eskimos in spite of a markedly lower arachidonate content in membrane lipids. In contrast formation of TXA2,3 was lower in Eskimos as compared to the Danish controls. We conclude, that the balance between PGI and TXA, which may regulate the interaction of platelet and vessel wall, is favourably shifted in Greenland Eskimos to an antithrombotic state.
PMID:3025932[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

125.
Prostaglandins Leukot Med. 1986 Jun;22(3):335-48.=Plasma prostaglandins: 6-keto-PGF1 alpha, TXB2 and PGE2 in juvenile-onset diabetes determined by high-pressure liquid chromatography and radio-immunoassay.=
Mourits-Andersen T, Jensen R, Dyerberg J.===Abstract===
Some studies have recently reported increased production of platelet thromboxane and decreased vascular prostacyclin in patients with diabetes mellitus. The impact of these changes on platelet and vascular functions in vivo is still speculative. Using radio-immunoassay and high pressure liquid chromatography we have studied the plasma levels of 6-keto-PGF1 alpha, TXB2 and PGE2 in 23 juvenile-onset diabetics. There was no significant difference in these plasma prostaglandins between the diabetics and a control group. The prostaglandins were neither correlated to blood-glucose nor the degree of glycosylation (HbA1c). Our results can not support the hypothesis that decreased vascular prostacyclin and increased platelet production of TXB2 are important factors in diabetic patients.
PMID:3460102[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

126.
Nutr Rev. 1986 Apr;44(4):125-34.=Linolenate-derived polyunsaturated fatty acids and prevention of atherosclerosis.=
Dyerberg J.===Erratum in===

• Nutr Rev 1986 Aug;44(8):282.

PMID:2872640[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

127.
Acta Med Scand. 1986;219(5):473-9.=Hemostatic factors and renin in Greenland Eskimos on a high eicosapentaenoic acid intake. Results of the Fifth UmanaK Expedition.=
Jørgensen KA, Høj Nielsen A, Dyerberg J.===Abstract===
The Fifth UmanaK expedition compared the fatty acid composition of platelets, bleeding times before and after ingestion of acetylsalicylic acid, 24-hour urinary tetranorprostanedioate, creatinine and Na output, as well as plasma renin, serum electrolytes and antithrombin III in 20 Greenland Eskimos and 20 Danes. The results indicate that the prostaglandin production was not inhibited in the Eskimos, and that the antiaggregatory prostanoids predominate in Eskimos compared to Danes. Although blood pressure and 24-hour urinary Na output were similar, the plasma renin level was significantly higher in the Eskimos on a high eicosapentaenoic acid intake.
PMID:3017055[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

128.
Prostaglandins Leukot Med. 1985 Oct;20(1):45-54.=Exercise decreases the platelet sensitivity to prostacyclin in patients with angina pectoris.=
Kristensen SD, Schmidt EB, Andersen HR, Dyerberg J.===Abstract===
Earlier reports have indicated, that the platelet sensitivity to prostacyclin (PGI2) is decreased in patients with coronary heart disease and that the onset of a spontaneous anginal attack is associated with a further decrease in platelet sensitivity to PGI2. We studied platelet function before and after bicycle exercise testing in 23 patients with angina pectoris and in 11 healthy males. We could not demonstrate any difference in platelet sensitivity to PGI2 between patients with angina pectoris and the controls neither before or after exercise testing. The platelet sensitivity to PGI2 decreased significantly after exercise, both in patients and in controls, but the decrease was not related to the development of myocardial ischemia. Our results could be interpreted in terms of different pathophysiological roles of platelets in spontaneous and in exercise-induced myocardial ischemia.
PMID:3906669[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

129.
Prostaglandins. 1985 Sep;30(3):465-77.=Long term 'marine diet' in Eskimos is not associated with altered urinary excretion of total tetranor prostaglandin metabolites.=
Zuccato E, Hornstra G, Dyerberg J.===Abstract===
The total urinary excretion of tetranor prostaglandin metabolites, measured as tetranorprostanedioic acid (TPD), was quantified in traditionally living Greenland Eskimos (E) and compared with that in Caucasian Danes (D). TPD excretion (microgram/24h) was not significantly different between both groups, neither for males (331 +/- 62.4 (E) vs. 331 +/- 25.7 (D), mean +/- SEM, n = 9 and 10) nor for females (190 +/- 31.7 (E) vs. 264 +/- 27.4 (D), n = 11 and 10, P2 greater than 0.05). Since urinary prostaglandin metabolites are thought to reflect the total prostaglandin turnover in vivo, these results suggest that a long-term intake of relatively large amounts of polyunsaturated fatty acids of the (n-3) family does not alter total prostaglandin turnover in vivo. This is in contrast to stimulated prostanoid formation in vitro, and thus suggests a different regulatory role of dietary and tissue fatty acids for 'stimulated' and 'basal' prostaglandin production.
PMID:4059579[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

130.
Thromb Res. 1985 Jun 15;38(6):687-93.=Interactions between sodium salicylate and acetyl salicylic acid evaluated using ADP induced platelet aggregation and bleeding time.=
Ring T, Dyerberg J.===Abstract===
1 g acetyl salicylic acid orally significantly enhanced the initial rate of platelet aggregation induced by 1 mumol/l and 2.5 mumol/l ADP. Sodium salicylate was without effects on the platelet aggregation and specifically it did not prevent acetylsalicylic acid from inhibiting the secondary aggregation. Sodium salicylate was without effect on the bleeding time and did not inhibit the prolongation induced by acetyl salicylic acid. Our study does not lend support to the concept of an important interaction in vivo between acetyl salicylic acid and its first metabolite salicylate in man.
PMID:4024050[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

131.
Scand J Clin Lab Invest. 1985 Jun;45(4):341-7.=Platelets and antithrombin III in uraemia: the acute effect of haemodialysis.=
Knudsen F, Dyerberg J.===Abstract===
In 14 haemodialysis patients, platelet count, secondary platelet aggregation rate, immunological antithrombin III and antithrombin III activity were lower and plasma beta-thromboglobulin higher than in 14 age- and sex-matched controls. In contrast, primary platelet aggregation, the degree of secondary aggregation and circulating platelet aggregates did not differ. Haemodialysis was associated with signs of platelet damage reflected by increase in plasma beta-thromboglobulin, extraction of platelets in the dialyser and decline in platelet count. Platelets in the dialyser effluent line were less aggregable than platelets in arterial blood. Circulating platelet aggregates and immunological antithrombin III were unchanged during dialysis whereas antithrombin III activity showed a minor rise. In conclusion, uraemics show a decreased rate of secondary platelet aggregation, and haemodialysis confers further platelet injury due to blood/surface interactions during extracorporeal circulation. The defective platelet function and low antithrombin III activity may help to explain the paradoxical occurrence of both haemorrhagic and thrombotic complications in uraemia.
PMID:3160101[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

132.
Thromb Res. 1985 May 1;38(3):243-9.=Protein C activity in renal disease.=
Sørensen PJ, Knudsen F, Nielsen AH, Dyerberg J.===Abstract===
Protein C activity was determined in 19 healthy controls and in 52 patients with renal diseases, clinically divided into three groups I) Nephrotic syndrome, II) Renal insufficiency, III) Terminal uremia, requiring maintenance dialysis. In the nephrotic syndrome protein C levels were found to be normal, but in renal insufficiency and terminal uremia the protein C activity was significantly decreased. A correlation between decreasing protein C and progressive renal failure is suggested. The reduced protein C activity may play an important role in the thrombotic tendency seen in renal diseases and uremia.
PMID:3839607[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

133.
Adv Prostaglandin Thromboxane Leukot Res. 1985;15:261-4.=Biological and chemical implications of a diet high in eicosapentaenoic acid: its influence on hemostasis and prostaglandin metabolism.=
Dyerberg J.PMID:3004138[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

134.
Thromb Res. 1984 Nov 15;36(4):305-14.=Eicosapentaenoic acid potentiates the production of prostacyclin-like material in the arachidonic acid perfused human umbilical vein.=
Kristensen SD, Arnfred T, Dyerberg J.===Abstract===
The production of prostacyclin (PGI2)-like material in human umbilical veins perfused continuously at 37 degrees C with Hanks buffer solution with 1% human albumin (HBA) was studied by bioassay. Subsequent perfusion resulted in a time dependent significant decrease in production of PGI2-like material. After addition of 20 mumol/l arachidonic acid (HBA-AA) the production of PGI2-like material increased significantly. The production of PGI2-like material was significant greater when the vein was perfused with HBA-AA than when perfused with HBA with 20 mumol/l eicosapentaenoic acid (HBA-EPA). Examination of the HBA-EPA perfusate by thin layer chromatography showed that it contained a substance that comigrated with genuine 6-keto-PGF1 alpha and a substance that comigrated with delta 17-6-keto-PGF1 alpha. Finally, perfusion with HBA containing 10 mumol/l AA plus 10 mumol/l EPA resulted in a significant greater production of PGI2-like material than perfusion with HBA-AA alone. These results support the hypothesis that EPA has beneficial antithrombotic properties in human.
PMID:6098049[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

135.
Lancet. 1984 Jul 28;2(8396):235-6.=Epoprostenol as sole antithrombotic treatment during haemodialysis.=
Knudsen F, Nielsen AH, Kornerup HJ, Pedersen JC, Dyerberg J.PMID:6146799[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

136.
Scand J Clin Lab Invest. 1984 May;44(3):203-6.=Cigarette smoking and its effects on the platelet-vessel wall interaction.=
Madsen H, Dyerberg J.===Abstract===
The effect of smoking and of carbon monoxide on the platelet-vessel wall interaction was investigated. After smoking two high-nicotine content cigarettes (2.6 mg nicotine/cigarette) the mean bleeding time decreased 1.6 min (P less than 0.05) in five habitual smokers whereas the platelet aggregability was only moderately inhibited. After inhibiting the platelet cyclooxygenase by ingesting acetylsalicylic acid (ASA) 2 days prior to the study, smoking caused a markedly and significantly shortened bleeding time (-3.8 min; P less than 0.05). The bleeding time was unaffected by smoking when both the platelet cyclooxygenase and the vessel wall prostaglandin was inhibited by ASA 1 h prior to the study. When smoking two cigarettes with a low content of nicotine (0.25 mg nicotine/cigarette) no changes in the haemostatic mechanism were observed. Inhalation of carbon monoxide in high amounts in five non-smokers had a significant short-lasting effect on the bleeding time (-1.2 min, P less than 0.05). No changes in the bleeding time were observed after carbon monoxide inhalation when the platelet cyclooxygenase or when both the platelet cyclooxygenase and the vessel wall prostaglandin production were blocked. Based on the results it is concluded that the effect of smoking on the haemostasis is mainly mediated through an inhibitory effect on the prostacyclin production in the vessel wall by nicotine and that carbon monoxide only plays a minor role.
PMID:6729389[PubMed – indexed for MEDLINE] Related citations
Icon for Informa Healthcare
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

137.
Contrib Nephrol. 1984;41:367-70.=Circulating platelet aggregates. A contributing factor to hemodialysis hypoxemia?=
Knudsen F, Nielsen AH, Stoffersen E, Kornerup HJ, Dyerberg J.PMID:6525855[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

138.
Scand J Clin Lab Invest Suppl. 1984;172:175-7.=External quality assessment programs in Denmark.=
Blom M, Brock A, Christensen F, Christensen NJ, Dyerberg J, Lauritsen OS, Raabo E, Starcke F, Uldall A.PMID:6599518[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms===

139.
Thromb Res. 1983 Dec 15;32(6):531-6.=Cigarette smoking shortens the bleeding time.=
Ring T, Kristensen SD, Jensen PN, Mourits-Andersen T, Madsen H, Dyerberg J.===Abstract===
The cutaneous bleeding time was shortened after smoking high nicotine cigarettes while not after smoking nicotine free cigarettes. The ADP induced primary platelet aggregation was not enhanced. The number of circulating platelet aggregates did not change due to smoking.
PMID:6665771[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

140.
Thromb Res. 1983 Nov 15;32(4):437-42.=Verapamil does not alter platelet function in patients with recent myocardial infarction.=
Kristensen SD, Schmidt EB, Dyerberg J.===Abstract===
Reports concerning the influence of the calcium antagonist verapamil on platelet function are conflicting. In a randomized double blind trial including 52 patients with acute myocardial infarction the effect of verapamil 120 mg given perorally three times a day for three months was investigated. There were no alterations in cutaneous bleeding time, platelet aggregate ratio or platelet aggregation induced by ADP or collagen. Verapamil administered in therapeutic doses does not seem to affect platelet function in patients with ischaemic heart disease.
PMID:6658721[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

141.
Thromb Haemost. 1983 Aug 30;50(2):543-6.=The effect of N-6 and N-3 polyunsaturated fatty acids on hemostasis, blood lipids and blood pressure.=
Mortensen JZ, Schmidt EB, Nielsen AH, Dyerberg J.===Abstract===
Diverging results from studies of marine oil supplementation to western diets initiated the undertaking of a double-blind crossover study, with administration to healthy volunteers for 4 weeks of either 10 g of fish oil or 10 g of vegetable oil. Each oil containing approx. 40% of n-3 and n-6 polyunsaturated fatty acids (PUFA) respectively. During the n-3 PUFA period, systolic blood pressure, plasma total lipids, triglycerides and VLDL concentrations fell significantly whereas plasma antithrombin-III (AT-III) rose. Cutaneous bleeding time increased significantly. In contrast only AT-III rose during the n-6 PUFA feeding, however, more marked than during the n-3 oil period. It is concluded that a n-3 PUFA oil supplement to the western diet exerts an effect that generally is considered as beneficial in terms of the risk of developing cardiovascular diseases. It is in this respect superior to that of n-6 PUFA, stressing the necessity of a more differentiated approach to advice on dietary PUFA enrichment than presently is exerted.
PMID:6636033[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

142.
Adv Nutr Res. 1983;5:57-75.=Platelets and atherosclerosis.=
Jørgensen KA, Dyerberg J.PMID:6303066[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

143.
Scand J Clin Lab Invest. 1982 Feb;42(1):83-6.=Antithrombin III and dietary intake of polyunsaturated fatty acids.=
Stoffersen E, Jørgensen KA, Dyerberg J.===Abstract===
Immunoreactive antithrombin III and antithrombin III activity was found to be significantly higher in 81 Greenland Eskimos than in 50 Caucasian Danes. Sixteen Eskimos who had emigrated to Denmark had significantly lower immunoreactive antithrombin III levels than the Greenland Eskimos, though higher than the Danes. The immunoreactive antithrombin III increased significantly while the increase in antithrombin III activity was insignificant in 20 male Caucasian Danes upon 3 weeks supplementation of the diet with 10 ml daily of a cod liver oil concentrate. The high antithrombin III level in the Eskimos may at least partly be a consequence of a high dietary intake of polyunsaturated fatty acids. It may also play a role for the low incidence of thrombosis apparently found in Greenland Eskimos.
PMID:7134791[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

144.
Hum Hered. 1982;32(1):49-51.=C3 polymorphism in Greenland Eskimos.=
Stoffersen E, Jørgensen KA, Nymand G, Dyerberg J.PMID:7068158[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

145.
Prog Lipid Res. 1982;21(4):255-69.=Marine oils and thrombogenesis.=
Dyerberg J, Jørgensen KA.PMID:6302714[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

146.
Scand J Clin Lab Invest Suppl. 1982;161:7-13.=A hypothesis on the development of acute myocardial infarction in Greenlanders.=
Dyerberg J, Bang HO.===Abstract===
Non-emigrated Greenlanders have a low incidence of acute myocardial infarction (AMI), when compared with age- and sex adjusted death rates for ischemic heart disease in western countries. We find that Greenlanders have plasma lipid levels corresponding to favourable risk factor levels for AMI. This can be attributed to their diet, rich in n-3 polyunsaturated fat. This diet further supplies eicosapentaenoic acid which influence platelet vessel wall function in an antithrombotic direction. A high level of plasma-antithrombin-III, raising the anticoagulant activity of the blood, in combination with a genetically high activation threshold for the complement system may further contribute to the resistancy against thrombo-embolic disorders. Bleeding tendency, and susceptibility to infection disorders may be the possible draw-backs. Our data are framed into a hypothesis combining the indications of genetic predispositions and the evidence of exogenous protective factors, inflicting a coherent enhancement of nonsusceptibility to vascular ischemic catastrophies.
PMID:6293041[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

147.
Prostaglandins. 1981 Dec;22(6):857-62.=Human umbilical blood vessel converts all cis-5, 8, 11, 14, 17 eicosapentaenoic acid to prostaglandin I3.=
Dyerberg J, Jørgensen KA, Arnfred T.===Abstract===
All cis-5, 8, 11, 14, 17 eicosapentaenoic acid (EPA) is presently being evaluated for dietary prophylactic use in thrombo-embolic disorders. EPA inhibits the production of TXA2 and platelet aggregation. We here present results demonstrating that human umbilical arteries convert 14c-EPA to a substance that in aqueous solutions decomposes to 14C-delta 17-6-keto-PGF1 alpha . The conversion rate in rat aortic tissue was found substantially lower. These results in combination with earlier data indicating that EPA does not influence the conversion of arachidonic acid (AA) into PGI2 in human vascular tissue, encourage further research along the lines initiated by the findings of high EPA/AA ratio and low incidence of myocardial infarction in Greenland Eskimos.
PMID:6278536[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

148.
Philos Trans R Soc Lond B Biol Sci. 1981 Aug 18;294(1072):373-81.=Platelet – vessel wall interaction: influence of diet.=
Dyerberg J.===Abstract===
The interaction of platelets with the vessel wall is influenced by the diet. Of major importance is the dietary polyunsaturated fatty acids (PUFA). Epidemiological evidence from Greenland Eskimos with low incidences of acute myocardial infarction has drawn attention to the role of the n – 3 PUFA family. Experiments in vitro have demonstrated an anti-aggregatory effect of eicosapentaenoic acid (EPA). However, EPA does not inhibit vascular prostacyclin production. Antiaggregatory substances generated from EPA have not yet been demonstrated in vivo. Studies in vivo in both animals and humans have demonstrated an antithrombotic effect of EPA. In a study where volunteers were given 6 g EPA per day for 3 weeks, moderate decreases in collagen-induced and ADP-induced platelet aggregation, lower thromboxane B2 (TXB2) synthesis and prolongation of bleeding time were found. These observations indicate the dietary factors modulate the interaction of platelets and the vessel wall. Dietary advice aiming at lowering the incidence of ischaemic diseases must include this aspect. This necessitates a re-evaluation of advice hitherto given to the population in general.
PMID:6117898[PubMed – indexed for MEDLINE] Related citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

149.
Ugeskr Laeger. 1981 Mar 15;143(11):684.=[Acquired von Willebrand's disease].=
[Article in Danish]
Sørensen PJ, Dyerberg J.PMID:6974424[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms===

150.
Acta Med Scand. 1981;210(4):245-8.=Personal reflections on the incidence of ischaemic heart disease in Oslo during the Second World War.=
Bang HO, Dyerberg J.===Abstract===
The dietary changes in Norway and especially in Oslo during the Second World War, with reduced fat intake and increased consumption of fish and fish products, was paralleled by a reduced incidence of and mortality from IHD. This was probably caused to a high degree by reduced platelet aggregability leading to a reduced tendency to thrombosis. We suggest that the mechanism behind this reduction was a changed balance between pro- and anti-aggregatory prostaglandins towards the anti-aggregatory side, caused by eicosapentaenoic acid from fish lipids. Furthermore, hypocholesterolaemia due to reduced fat intake and increased consumption of polyunsaturated fatty acids certainly contributed to this effect by reducing platelet aggregability.
PMID:7032231[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

151.
Dan Med Bull. 1980 Dec 6;27(6):253-9.=Platelets and atherosclerosis. A review on the role of platelets in atherosclerosis with special reference to the role of polyunsaturated 20 carbon fatty acids.=
Jørgensen KA, Dyerberg J.PMID:7006931[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

152.
Am J Clin Nutr. 1980 Dec;33(12):2657-61.=The composition of the Eskimo food in north western Greenland.=
Bang HO, Dyerberg J, Sinclair HM.===Abstract===
In the winter of 1976 an examination of the composition of Eskimo food was carried out in north western Greenland. Duplicate specimens of diets collected from 50 adults, equal numbers of males and females, were analyzed for water, ash, protein, fat, individual fatty acids, cholesterol, and carbohydrate. The results are compared with those of typical Danish diets. Seal and the fish are predominant Eskimo food. Marked differences between Eskimo and Danish food were found. The Eskimo diets were richer in polyunsaturated fatty acids, the ratio to saturated fatty acids was 0.84 as compared with 0.24 in Danes. The polyunsaturated fatty acids were predominantly of the linolenic class (n-3) in Eskimos and the linoleic class (n-6) in Danes. Monoenes other than palmitoleic and oleic acids were high in Eskimo diets, but negligible in Danish. The results are related to previous examinations of the plasma lipids in Eskimos. The rarity of ischemic heart disease in Greenland Eskimos may partly be explained by the antithrombotic effect of the long-chained polyunsaturated fatty acids, especially eicosapentaenoic acid prevalent in diets rich in marine oils.
PMID:7435433[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

153.
Thromb Res. 1980 Dec 1-15;20(5-6):611-5.=Acetylsalicylic acid and bleeding time in juvenile diabetes mellitus.=
Jørgensen KA, Mourits-Andersen HT, Ditzel J, Dyerberg J.PMID:7233387[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

154.
Thromb Res. 1980 Sep 15;19(6):799-805.=Acetylsalicylic acid, bleeding time and age.=
Jørgensen KA, Dyerberg J, Olesen AS, Stoffersen E.PMID:7466748[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

155.
Thromb Res. 1980 Sep 15;19(6):877-81.=A biphasic effect of prostacyclin (PGI2) on platelet aggregation.=
Jørgensen KA, Dyerberg J, Stoffersen E.PMID:6258262[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

156.
Dan Med Bull. 1980 Sep;27(4):202-5.=The bleeding tendency in Greenland Eskimos.=
Bang HO, Dyerberg J.PMID:7438807[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms===

157.
Am J Clin Nutr. 1980 Aug;33(8):l814-7.=Marine docosenoic acid isomer distribution in the plasma of Greenland Eskimos.=
Ackman RG, Eaton CA, Dyerberg J.===Abstract===
The natural docosenoic acid in the human diet can be predominantly 22:1 omega 9 if of plant (generally rapeseed oil) origin, or predominantly 22:1 omega 11 if of marine origin. The fatty fatty acids of dietary fats (meals) and plasma lipids of some Greenland eskimos were examined by open-tubular gas-liquid chromatography. The dietary docosenoic acid isomer distribution pattern showed 22:1 omega 11 to be about 5 times 22:1 omega 9, a ratio typical of marine mammal fats. A similar ratio was also found in the plasma fatty acids, but with a slightly higher proportion of 22:1 omega 9. When correlated with the excellent cardiovascular health of Greenland eskimos, the docosenoic acid data suggest that current concern as to the impact of dietary docosenoic acids on the human myocardium, largely based on animal feeding studies, may be exaggerated.
PMID:7190776[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

158.
Ugeskr Laeger. 1980 Jun 16;142(25):1597-600.=[Proposed method for the prevention of thrombosis. The Eskimo model].=
[Article in Danish]
Dyerberg J, Bang HO.PMID:7404757[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

159.
Ugeskr Laeger. 1980 Mar 17;142(12):743-7.=[Pharmacological effects on thrombocyte aggregation. A review].=
[Article in Danish]
Jøorgensen KA, Dyerberg J.PMID:6989071[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

160.
Scand J Haematol. 1980 Feb;24(2):105-9.=Familial functional antithrombin III deficiency.=
Sørensen PJ, Dyerberg J, Stoffersen E, Jensen MK.===Abstract===
A family with a tendency to thrombosis and decreased antithrombin III (AT III) activity in plasma, but normal immunoreactive AT III is reported. 7 members of the family had the AT III defect, 4 of whom have had thrombotic episodes. The importance of biological determination of AT III when studying patients with recurrent thrombotic episodes is emphasized.
PMID:7375809[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

161.
Lancet. 1980 Jan 26;1(8161):199.=alpha-Linolenic acid and eicosapentaenoic acid.=
Dyerberg J, Bang HO, Aagaard O.PMID:6101648[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

162.
Acta Haematol. 1980;63(5):278-82.=Recurrent thrombosis in a patient with factor XII deficiency.=
Dyerberg J, Stoffersen E.===Abstract===
The case history of a patient with moderate factor XII deficiency and recurrent deep vein thrombosis is described. A decreased resting fibrinolytic capacity suggests that 'in vivo' Hageman factor acts mainly as a promotor of clot dissolution. It further indicates that the in vitro demonstration of factor XII as an activator for other biochemical pathways might be of minor importance in vivo, as alternative pathways for activation of these systems exist.
PMID:6774556[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

163.
Artery. 1980;8(1):12-7.=The effect of arachidonic- and eicosapentaenoic acid on the synthesis of prostacyclin-like material in human umbilical vasculature.=
Dyerberg J, Jørgensen KA.===Abstract===
All cis-5,8,11,14,17 eicosapentaenoic acid (EPA) inhibits platelet aggregation. The mechanisms for this inhibition are not known in detail. One of them might be a competitive inhibition of TXA2 production. Even if rat and human vasculature in pure systems covert EPA to PGI3 with the same properties as PGI2, it is essential to known if EPA influences the conversion of arachidonic acid (AA) to PGI2 in human vasculature. This problem was investigated in human umbilical vascular tissue deprived of substrate for PGI synthesis. After incubation with AA or EPA alone and in combinations, prostacyclin synthesis was measured as PGI2. Prostacyclin production in assays with AA and EPA in combinations in the incubation mixture, was found additive as calculated from assays with pure substrates. Thus, EPA did not influence the conversion of AA to PGI2 but gave obviously rise to additional synthesis of PGI-like material.
PMID:6252872[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

164.
Scand J Clin Lab Invest. 1980;40(7):589-93.=All cis-5, 8, 11, 14, 17 eicosapentaenoic acid and triene prostaglandins: potential anti-thrombotic agents.=
Dyerberg J, Bang HO.PMID:6258218[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

165.
Ugeskr Laeger. 1979 Oct 29;141(44):3040-2.=[A case of factor XI deficiency–hemophilia C].=
[Article in Danish]
Ingeberg S, Dyerberg J, Stoffersen E, Olesen AS.PMID:494423[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms===

166.
Lancet. 1979 Sep 1;2(8140):433-5.=Haemostatic function and platelet polyunsaturated fatty acids in Eskimos.=
Dyerberg J, Bang HO.===Abstract===
Death from cardiovascular disease is rare among Eskimos. Haemostasis was investigated in twenty-one Greeland Eskimos and twenty-one age and sex matched Danish controls. Platelet lipid analysis demonstrated that a high consumption of omega-3 polyunsaturated fatty acids (such as cis 5, 8, 11, 14, 17-eicosapentaenoic acid [C20:5]) by Eskimos increased the proportion of omega-3 polyunsaturated fatty acids in the platelets. The Eskimos had a significantly longer bleeding-time due to a reduction in platelet aggregation. It is suggested that C20:5 in the platelets is converted by the vascular-wall tissue to an anti-aggregatory prostacyclin. Partial dietary substitution of arachidonic acid by eicosapentaenoic acid may reduce the incidence of thrombotic disorders, including myocardial infarction.
PMID:89498[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

167.
Lancet. 1979 Aug 11;2(8137):302.=Aspirin and bleeding-time: dependency of age.=
Jorgensen KA, Olesen AS, Dyerberg J, Stoffersen E.PMID:88626[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

168.
Pharmacol Res Commun. 1979 Jul;11(7):605-15.=Prostacyclin (PGI2) and the effect of phosphodiesterase inhibitors on platelet aggregation.=
Jørgensen KA, Dyerberg J, Stoffersen E.PMID:388470[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

169.
Lancet. 1979 Jun 23;1(8130):1352.=Stability of prostacyclin in plasma.=
Jørgensen KA, Stoffersen E, Dyerberg J.PMID:87815[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

170.
Haemostasis. 1979;8(3-5):227-33.=Lipid metabolism, atherogenesis, and haemostasis in Eskimos: the role of the prostaglandin-3 family.=
Dyerberg J, Bang HO.===Abstract===
In Eskimos coronary heart disease is a rarity. This can partly be explained by their favorable plasma lipid levels. An additional factor seems, however, to be that in Eskimo food polyunsaturated fatty acids of the omega-3 series replace those of the omega-6 series. C20:5, omega-3 can be converted by the vessel wall to an antiaggregatory substance, whereas it has no proaggregatory effect on platelets. Consistent with these findings Eskimos were found to have a nearly 2-fold longer bleeding time than Danes. Platelet aggregability, too, was markedly depressed when exposing platelets from Eskimos to ADP and collagen.
PMID:511010[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

171.
Lancet. 1978 Jul 15;2(8081):117-9.=Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis?=
Dyerberg J, Bang HO, Stoffersen E, Moncada S, Vane JR.===Abstract===
Unlike arachidonic acid (eicosatetraenoic acid, C20:4omega-6, A.A.), eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.P.), probably because of the formation of thromboxane A3 (T.X.A3) which does not have platelet aggregating properties. Moreover, E.P.A., like A.A., can be utilised by the vessel wall to make an anti-aggregating substance, probably a delta17-prostacyclin (P.G.I3). This finding suggests that, in vivo, high levels of E.P.A. and low levels of A.A. could lead to an antithrombotic state in which an active P.G.I3 and a non-active T.X.A3 are formed. Eskimos have high levels of E.P.A. and low levels of A.A. and they also have a low incidence of myocardial infarction and a tendency to bleed. It is possible that dietary enrichment with E.P.A. will protect against thrombosis.
PMID:78322[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

172.
Acta Paediatr Scand. 1978 Jul;67(4):533-6.=The absence of factor II in a child with systemic lupus erythematosus.=
Lillquist KB, Dyerberg J, Krogh-Jensen M.===Abstract===
This report describes a patient with active system lupus erythematosus (SLE), who developed haemorrhagic diathesis due to a lowering of plasma factor II activity. No evidence was found suggesting a plasma inhibitor of factor II. The present case indicates that in some patients with SLE, factor II activity may be low or completely absent due to impairment of factor II synthesis, further that prednisone, but not azathioprine, may ameliorate this defect.
PMID:676741[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

173.
Acta Neurol Scand. 1978 May;57(5):432-7.=Plasma lipids and lipoproteins in young patients with brain infarction.=
Jørgensen FS, Dyerberg J, Hjørne N, Ewald J.===Abstract===
Thirty-two patients aged 60 or less with brain infarction were examined with regard to possible changes in lipoprotein pattern as compared with a reference group. Except for a lower concentration of total lipids, cholesterol and high-density lipoproteins in the female patients, no difference was demonstrated in the two groups. In all patients a significant reduction in total lipids, cholesterol, triglyceride and all lipoproteins was demonstrated after the acute cerebrovascular accident presumedly due to the stress situation.
PMID:209655[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

174.
Clin Chem. 1978 Mar;24(3):515-7.=Modified continuous-flow determination of alpha-amylase activity in serum and urine with the Phadebas amylase test.=
Knudsen WK, Arnfred T, Dyerberg J, Fogh K.PMID:305323[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

175.
Lancet. 1978 Jan 21;1(8056):152.=Dietary fat and thrombosis.=
Dyerberg J, Bang HO.PMID:87584[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

176.
Ugeskr Laeger. 1977 Jul 18;139(29):1715-9.=[Afibrinogenemia and the Bernard-Soulier syndrome].=
[Article in Danish]
Dyerberg J, Jensen MK, Stoffersen E.PMID:898353[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">Publication Types, MeSH Terms===

177.
Adv Exp Med Biol. 1977 Jul 4-7;94:395-9.=Oxygen transport impairment induced by three major cardiovascular risk factors.=
Ditzel J, Jaeger P, Dyerberg J.PMID:26173[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

178.
Dan Med Bull. 1977 Apr;24(2):52-5.=Plasma cholesterol concentration in Caucasian Danes and Greenland West-coast Eskimos.=
Dyerberg J, Bang HO, Hjorne N.PMID:852313[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

179.
J Lab Clin Med. 1977 Mar;89(3):573-80.=The oxyhemoglobin dissociation curve in patients with familial hyperchylomicronemia.=
Ditzel J, Dyerberg J.===Abstract===
In order to study the effect of marked chylomicronemia on red cell oxygen release, oxygen hemoglobin dissociation curves (ODC's) from zero to full saturation were determined on whole blood from three siblings with familial Type I hyperlipoproteinemia. In these cases the oxygen affinity of hemoglobin was markedly increased, with P50 act. pH varying between 22.1 and 17.7 mm. Hg (normal value, 27.3 mm. Hg; S.D., 1.3) and the Hill coefficient n reflecting the slope of the ODC was increased. The changes in the ODC's are thought to be secondary to the hyperchylomicronemia for the following reasons: (1) the change was minimized by incubating red cells from the patients in normal donor plasma; (2) normal red cells increased their oxygen affinity when incubated in lactescent plasma; (3) the change was not explainable by a decrease in red cell 2,3-diphosphoglycerate content or in arterial blood hydrogen ion concentration. Based on these findings a decreased erythrocyte oxygen release of one third can be hypothesized. The importance of this observation in relation to the symptomatology of clinical conditions complicating marked chylomicronemia is discussed.
PMID:618355[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

180.
Metabolism. 1977 Feb;26(2):141-50.=Hyperlipoproteinemia, diabetes, and oxygen affinity of hemoglobin.=
Ditzel J, Dyerberg J.===Abstract===
Oxyhemoglobin dissociation curves (ODC) were performed on blood from diabetic and nondiabetic subjects with and without hypertriglyceridemia. P50 at in vivo pH was slightly lower than normal in normolipemic diabetics (25.7 versus 26.6 mmHg, p less than 0.05), in spite of increased red cell 2,3-diphosphoglycerate concentration (15.4 versus 14.4 mumole/g Hg, p less than 0.025). P50 at in vivo pH in diabetics with moderately elevated very low density lipoproteins (VLDL)–Type IV hyperlipoproteinemia (HLP)–was likewise found to be slightly lower than normal (25.5 versus 26.6 mmHg, p less than 0.05). In contrast, diabetics with pronounced hyperlipemia due to accumulation of chylomicrons (type I HLP) or due to accumulation of chylomicrons (type I HLP) or due to accumulation of chylomicrons as well as VLDL (type V HLP) showed markedly increased hemoglobin–oxygen affinity (P50:21.1 versus 26.6 mmHg, p less than 0.001). The change in the ODC of normolipemic diabetics is considered to be an expresssion of the presence of an increased proportion of a hemoglobin fraction (Hb Alc) with increased oxygen affinity. The additional change in the ODC of the hyperlipemic patients is thought to be secondary to accumulation of triglyceride-rich particles for the following reasons: (1) a similar increase in oxygen affinity of hemoglobin was demonstrated in familial type I HLP of nondiabetic subjects; (2) normal red cells increased their oxygen affinity when incubated in lactescent plasma; (3) in both acquired types I and V HLP the disappearance of HLP was followed by a normalization of the ODC.
PMID:13260[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

181.
Bibl Anat. 1977;(15 Pt 1):433-5.=Oxygen transport impairment by hyperchylomicronemia.=
Ditzel J, Dyerberg J.PMID:23098[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

182.
Clin Chem. 1976 Feb;22(2):205-10.=Evaluation of a dipstick test for glucose in urine.=
Dyerberg J, Pedersen L, Aagaard O.===Abstract===
As an example of qualitative tests, a dipstick analysis for glucose in urine has been tested for the influence of modifying factors on the test result. Two different types of dipsticks were examined, "Clinistix" and "S-Gluko-test." Used according to manufacturer's instructions, the latter is more sensitive and selective. By multivariance analysis the following variables were examined: urine samples, inter- and intra-analyst, exposure to light, and dipstick batch. The first three contributed significantly to the total variation in results, inter-specimen variation being the most important. With knowledge of the frequency of testing urines with a given glucose concentration and the probability of the result at that concentration, an expression of the probability of the glucose content of a urine sample can be obtained. Even with the tests of the type examined having a sensitivity and specificity exceeding 95%, 14 of 100 patients suspected of having diabetes mellitus on the basis of a dipstick examination will be found to have a urinary glucose concentration of less than 2 mmol/liter. These figures were found when the prevalence of urines with a glucose concentration exceeding 2 mmol/liter was 17.5%.
PMID:1248121[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

183.
Acta Med Scand. 1976;200(1-2):69-73.=The composition of food consumed by Greenland Eskimos.=
Bang HO, Dyerberg J, Hjøorne N.===Abstract===
Food specimens have been collected, by means of the double-portion technique, from Greenland Eskimo hunters and their wives, in all seven persons, on seven consecutive days. Their food was found to contain more protein and less carbohydrates than average Danish food and an almost equal amount of fat. Compared with Danish food, the fatty acid pattern of the consumed lipids–essentially of mammalian marine origin–showed a higher content of long chain polyunsaturated fatty acids (especially C20:5) and lower contents of linoleic and linolenic acids. However, the sum of the polyunsaturated fatty acids was smaller than in Danish food. Using Keys' formula, describing the serum cholesterol level as a function of the nutritional fatty acids, the essentially lower serum choelsterol level found in Greenland Eskimos was not explained by our findings. It is suggested instead to be a special metabolic effect of the long chain polyunsaturated fatty acids from marine mammals. There might be a similar effect on the plasma triglyceride and very low density lipoprotein concentrations, explaining the much lower plasma concentrations of these components in Eskimos than in Western populations. Our findings might have an essential bearing on the difference in morbidity from coronary atherosclerotic disease between these populations.
PMID:961471[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

184.
Ugeskr Laeger. 1975 Nov 17;137(47):2786-7.=[A case of collagenosis treated with tranexamic acid (Cyclocapron)].=
[Article in Danish]
Nymand G, Dyerberg J.PMID:1189103[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

185.
Lancet. 1975 Sep 20;2(7934):546.=Letter: Tranexamic acid: a new approach to autoimmune disease?=
Nymand G, Dyerberg J.PMID:51359[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

186.
Am J Clin Nutr. 1975 Sep;28(9):958-66.=Fatty acid composition of the plasma lipids in Greenland Eskimos.=
Dyerberg J, Bang HO, Hjorne N.===Abstract===
Gas-liquid chromatography analyses have been carried out to investigate the composition of esterified fatty acids in the plasma lipids in 130 Greenland Eskimos, compared with those of 32 Greenland Eskimos living in Denmark and of 31 Caucasian Danes in Denmark. While the Eskimos living in Denmark did not differ substantially from other persons living in Denmark and, from what is found in other studies in Western communities, the Greenland Eskimos showed a completely different pattern. They demonstrated a much higher proportion of palmitic, palmitoleic, and timnodonic acids, while they had a markedly lower concentration of linoleic acid. The total concentration of polyunsaturated fatty acids was lower in Greenland Eskimos than in the other groups. These findings are discussed in the light of the generally accepted opinion of the beneficial effect on plasma lipid levels and on the morbidity of coronary atherosclerosis of a high dietary intake of polyunsaturated fatty acids. As plasma lipid and lipoprotein levels in Greenland Eskimos in a previous study were found markedly lower than those found in Western populations, and as coronary atherosclerosis seems to occur far less commonly among Eskimos in Greenland than among peoples in industrialized countries, it was found difficult to combine these observations with the results from the present study. If dietary differences are the main reason for the differences in plasma lipid concentrations, the results from the present study point more toward qualitative than toward quantitative differences in respect of fatty acid composition of the food.
PMID:1163480[PubMed – indexed for MEDLINE] Free full textRelated citations
Icon for HighWire
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

187.
Ugeskr Laeger. 1975 Jul 14;137(29):1641-6.=[Fat content of the blood and composition of the diet in a population group in West Greenland].=
[Article in Danish]
Bang HO, Dyerberg J.PMID:1154511[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

188.
Clin Chim Acta. 1975 May 15;61(1):103-4.=Comments on the quantitation of lipoproteins by agarose-gel electrophoresis.=
Dyerberg J.PMID:168004[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

189.
Ugeskr Laeger. 1975 Jan 6;137(2):89.=[Familial type V hyperlipoproteinemia].=
[Article in Danish]
Dyerberg J.PMID:164072[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

190.
Acta Paediatr Scand. 1974 May;63(3):431-6.=Reference values for cord blood lipid and lipoprotein concentrations.=
Dyerberg J, Hjorne N, Nymand G, Olsen JS.PMID:4365177[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

191.
Ugeskr Laeger. 1974 Apr 1;136(14):769.=[Familial hyperlipoproteinemia type IV].=
[Article in Danish]
Dyerberg J.PMID:4363634[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

192.
Ugeskr Laeger. 1974 Mar 18;136(12):652-3.=[Familial type 3 hyperlipoproteinemia].=
[Article in Danish]
Dyerberg J.PMID:4365256[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

193.
Ugeskr Laeger. 1974 Jan 14;136(3):125-9.=[Familial hyperchylomicronemia or Type I hyperlipoproteinemia].=
[Article in Danish]
Damgaard-Pedersen F, Dyerberg J.PMID:4840835[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

194.
Ugeskr Laeger. 1974 Jan 14;136(3):165-6.=[Editorial: Hyperlipidemia].=
[Article in Danish]
Dyerberg J.PMID:4822285[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

195.
Scand J Clin Lab Invest. 1973 Jun;31(4):473-9.=Plasma lipid and lipoprotein levels in childhood and adolescence.=
Dyerberg J, Hjörne N.PMID:4357531[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

196.
Clin Chim Acta. 1973 Jan 24;43(2):283-4.=Quantitation of the -lipoprotein complex by agarose gel electrophoresis.=
Dyerberg J, Hjorne N.PMID:4120027[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

197.
Acta Med Scand. 1972 Jul-Aug;192(1-2):85-94.=Plasma lipids and lipoproteins in Greenlandic west coast Eskimos.=
Bang HO, Dyerberg J.PMID:5052396[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

198.
Acta Med Scand. 1972 May;191(5):413-21.=Plasma lipid and lipoprotein levels in a Danish population.=
Dyerberg J, Hjorne N.PMID:4337998[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

199.
Clin Chim Acta. 1971 Jul;33(2):458-61.=Quantitation of the -lipoprotein complex by agarose gel electrophoresis.=
Dyerberg J, Hjorne N.PMID:4107523[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

200.
Lancet. 1971 Jun 5;1(7710):1143-5.=Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos.=
Bang HO, Dyerberg J, Nielsen AB.PMID:4102857[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===
====MeSH Terms====

• Blood Protein Electrophoresis
• Coronary Disease/epidemiology
• Denmark
• Diabetes Mellitus/epidemiology
• Dietary Fats*
• Fatty Acids, Essential
• Female
• Greenland
• Humans
• Inuits*
• Lipids/blood*
• Lipoproteins/blood*
• Male
• Meat
• Triglycerides/blood

Substances

• Dietary Fats
• Fatty Acids, Essential
• Lipids
• Lipoproteins
• Triglycerides

201.
Nord Med. 1970 Nov 26;84(48):1539.=[Treatment of hyperlipemia with a new lipid decreasing drug (Ciba 13,437-Su)].=
[Article in Danish]
Hede S, Ditzel J, Dyerberg J.PMID:5486044[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

202.
Nord Med. 1970 Nov 26;84(48):1538.=[Lipid and ipoprotein analysis–clinical chemical overview–indication for lipid analysis].=
[Article in Danish]
Dyerberg J.PMID:5486041[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

203.
Ugeskr Laeger. 1970 Nov 26;132(48):2267-74.=[Lipids and lipoproteins in plasma. Metabolism and pathophysiology–a clinical-chemical survey].=
[Article in Danish]
Dyerberg J.PMID:5487359[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

204.
Clin Chim Acta. 1970 Nov;30(2):407-13.=Quantitative plasma lipoprotein electrophoresis. Correction for the difference in dye uptake by the lipoprotein fractions.=
Dyerberg J, Hjorne N.PMID:4097855[PubMed – indexed for MEDLINE] Related citations
Icon for Elsevier Science
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

205.
Nord Med. 1970 Jul 30;84(31):998.=[Lipoprotein pattern in patients with coronary occlusion].=
[Article in Danish]
Bang HO, Dyerberg J, Nielsen JA.PMID:5453115[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

206.
Acta Med Scand. 1970 May;187(5):353-63.=Plasma lipids and lipoproteins in patients with myocardial infarction and in a control material.=
Dyerberg J, Bang HO, Nielsen JA.PMID:5526953[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

207.
Clin Chim Acta. 1970 Apr;28(1):203-8.=Quantitative plasma lipoprotein estimation by agarose gel electrophoresis.=
Dyerberg J, Hjorne N.PMID:5440285[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

208.
Lancet. 1970 Feb 21;1(7643):422-3.=Treatment of essential hyperlipidaemia.=
Dyerberg J, Hjorne N.PMID:4189734[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

209.
J Atheroscler Res. 1969 Jul-Aug;10(1):5-10.=The cholesterol-lowering effect of dextran-40.=
Ditzel J, Dyerberg J.PMID:4909188[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

210.
Metabolism. 1969 Jan;18(1):50-7.=Type 3 hyperlipoproteinemia with low plasma thyroxine binding globulin.=
Dyerberg J.PMID:4974533[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

211.
Acta Med Scand. 1968 Nov;184(5):441-9.=Fatty acid composition of the plasma lipids in hypothyroid subjects.=
Dyerberg J.PMID:5732559[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

212.
Ugeskr Laeger. 1968 Feb 29;130(9):359-64.=[Lipoprotein pattern in hyperlipidemia].=
[Article in Danish]
Dyerberg J.PMID:5698356[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

213.
Ugeskr Laeger. 1967 Nov 2;129(44):1490.=[Qualitative determination of proteins in the urine].=
[Article in Danish]
Dyerberg J.PMID:5594984[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

214.
Ugeskr Laeger. 1967 Sep 7;129(36):1139-43.=[Deferoxamine-B test. Evaluation of the organism's iron content by loading with a ferriuretic chelate].=
[Article in Danish]
Bennike T, Dyerberg J.PMID:5598852[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===

215.
Ugeskr Laeger. 1967 Sep 7;129(36):1135-9.=[Deferoxamine-B, a ferriuretic chelate].=
[Article in Danish]
Dyerberg J.PMID:4880917[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.

216.
Nord Med. 1967 Jan 12;77(2):43-7.=[Uptake of 125-I-labelled 1-triiodothyronine by human erythrocytes and Sephadex G 25 medium as an in-vitro test of thyroid function].=
[Article in Danish]
Dyerberg J, Hauerbach T, Holm-Andersen U, Holme N, Kruse F, Nielsen JA.PMID:6021421[PubMed – indexed for MEDLINE] Related citations
The following toggler user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.
#####none;">MeSH Terms, Substances===