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antibiotika plus iltbehandling

Chokbehandling med ilt under tryk booster virkning af antibiotika Dansk forskning viser, at antibiotika virker bedre, hvis behandlingen kombineres med ilt-tilførsel under tryk. Teorien er, at ilt-chokket gør, at medicinen kan trænge længere ind i en betændelsestilstand.


Autism Starts Months before Symptoms Appear, Study Shows Flagging children early offers the possibility of more effective treatment —


Autism detectable in brain long before symptoms appear The discovery could lead to better tests and therapies for children with autism.


Brain scans spot early signs of autism in high-risk babies Experts say replication is needed and other hurdles must be surmounted to apply findings to the clinic. Nature News doi: 10.1038/nature.2017.21484


MRIs predict which high-risk babies will develop autism as toddlers Using magnetic resonance imaging (MRI) in infants with older siblings with autism, researchers from around the country were able to correctly predict 80 percent of those infants who would later meet criteria for autism at two years of age.


What's holding up CRISPR-based cures The gene-editing tool called CRISPR that can quickly and cleanly remove specific pieces of DNA has revolutionized biotechnology. Many researchers believe the technique could end thousands of ailments. So what's needed to realize CRISPR's potential? Another breakthrough. The cover story in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, runs down the la

CRISPR patent

Broad Institute Wins Big Battle Over CRISPR Gene-Editing Patent CRISPR technology is already worth billions of dollars, investors say. This ruling seems to affirm the biggest piece of the pie goes to the Broad, over patent rival University of California, Berkeley.

CRISPR patent

Broad Institute wins bitter battle over CRISPR patents The US Patent and Trademark Office issues a verdict in legal tussle over rights to genome-editing technology. Nature News doi: 10.1038/nature.2017.21502

CRISPR patent

Disputed CRISPR Patents Stay with Broad Institute, U.S. Panel Rules Three judges have released their decision —

CRISPR patent

Patent Office Hands Win in CRISPR Battle to Broad Institute The dispute between researchers at UC Berkeley and the Broad Institute over the invention of the powerful gene-editing technique has been decided.


Datagiganter har fri leg i Danmark, mens Datatilsynet jager småsyndere Mens Datatilsynet holder skarpt øje med danske forskere, så fortsætter store amerikanske datagiganter som Facebook, Apple og Google deres massive dataindsamling uden for (vor) lands lov og ret. Version2


How depression can muddle thinking Depression is associated with sadness, fatigue and a lack of motivation. But people with depression can also have trouble processing information and solving problems. Now scientists studying a rat model for depression are identifying on a molecular level how the condition could affect thinking. The findings could lead to the development of new depression treatments that would address associated co


Is Your Diet Fighting Depression – or Intensifying It? We know there's a gut-brain connection, but just how deep does it go? Could we treat depression just by adopting a particular diet?

Heat Sensor Has Snaky Sensitivity Researchers have developed a heat sensor that can detect temperature changes of just ten thousandths of a degree Celsius—comparable to the sensitivity of pit vipers. Christopher Intagliata… —

Laissez-faire is not good enough for reforestation If degraded and logged areas of tropical forests are left to nature, the populations of certain endangered tree species are not able to recover. This applies in particular to trees with large fruit where the seeds are distributed by birds, as scientists have shown in a rainforest in India.

Signals from fat may aid diagnostics and treatments Scientists now have identified a route by which fat also can deliver a form of small RNAs called microRNAs that helps to regulate other organs. This mechanism may offer the potential to develop an entirely new therapeutic approach.

Chest pain: New tool helps doctors decide when tests are needed Stress testing may not always be necessary for those with non-urgent chest pain, suggest researchers in a new report.

Size matters when it comes to keeping blood sugar levels in check Keeping blood sugar levels within a safe range is key to managing both type 1 and type 2 diabetes. In a new finding that could lead to fewer complications for diabetes patients, researchers have found that changes in the size of mitochondria in a small subset of brain cells play a crucial role in safely maintaining blood sugar levels.

Electronic sensor system to prevent mining explosions A wireless network of sensors aimed at preventing explosions in mines is an innovation of worldwide significance that is being developed by a Norwegian-African cooperative project.

Pattern Storage, Bifurcations and Higher-Order Correlation Structure of an Exactly Solvable Asymmetric Neural Network Model Exactly solvable neural network models with asymmetric weights are rare, and exact solutions are available only in some mean-field approaches. In this article we find exact analytical solutions of an asymmetric spin-glass-like model of arbitrary size and we perform a complete study of its dynamical and statistical properties. The network has discrete-time evolution equations, binary firing rates a

Harvard and M.I.T. Scientists Win Gene-Editing Patent Fight The ruling gives the Broad Institute the potentially lucrative rights, a blow to the University of California, often said to be the birthplace of the technique.

A Wet Winter Is Overwhelming California’s Ancient Infrastructure More than a month of storms have pushed California's water infrastructure to its limits. And another series of storms is set to hit tomorrow.

I've started podcasting about cognitive science, and this is the first episode. What is the speed of thought? submitted by /u/Doofangoodle [link] [comments]

For Food Manufacturers, 'Sell By' Labels May Have Reached Their Expiration Date Those "expiration" labels on packaged food may confuse consumers and dupe them into throwing good food in the trash. Two major food industry associations want to change that and are proposing reforms.

Using 'Scotch tape' and laser beams, researchers craft new material that could improve LED screens A cover story appearing in the peer-reviewed journal Nanoscale Horizons reports a new bilayer material, with each layer measuring less than one nanometer in thickness, that someday could lead to more efficient and versatile light emission.

3-D printed 'eagle eye' camera mimics sharp vision of predators A new study presents a miniaturized camera inspired by the natural vision of predators such as eagles that captures images with a high central acuity.

Grab $18 Million and Drive Home a Stunning 1950s Jaguar One of just 16 like it.

Here are the winners of NASA's space poop challenge Space Three designs for an in-suit toilet take home $30,000 Poopin' ain't easy in space. That's why NASA set up a competition to gather ideas for a better space suit toilet.

Brain Tumor Triggers Woman's Sudden 'Hyper-Religious' Behavior A woman in Spain who suddenly became very religious and believed she was speaking with the Virgin Mary actually had a brain tumor that appears to have caused her symptoms.

EU parliament backs draft carbon trading reforms The European Parliament on Wednesday adopted draft reforms of Europe's carbon market after 2021, a key step in reaching the bloc's climate change goals.

Colorado's 834 million dead trees threaten to worsen fires (Update) Colorado's beetle-infested forests are peppered with an estimated 834 million standing dead trees that threaten to worsen wildfires and degrade vital water supplies that flow from mountains, officials said Wednesday.

Spotify expands with World Trade Center move Spotify on Wednesday announced an expansion amid the rapid growth of streaming, with the company moving its US headquarters to New York's rebuilt World Trade Center complex.

Corps to accelerate cleanup at oil pipeline protest camp The U.S. Army Corps of Engineers plans to hire a contractor to accelerate cleanup efforts at a camp in southern North Dakota that has housed hundreds and sometimes thousands of Dakota Access pipeline opponents.

Yahoo issues another warning in fallout from hacking attacks Yahoo is warning users of potentially malicious activity on their accounts between 2015 and 2016, the latest development in the internet company's investigation of a mega-breach that exposed 1 billion users' data several years ago.

13 pet gifts fit for a champion at Westminster Gadgets Doggie swag. 13 things to make you and your dog feel like you won Best in Show. Read on.

UN addresses issue of whale-ship collisions Scientists and government officials met at the United Nations today to consider possible solutions to a global problem: how to protect whale species in their most important marine habitats that overlap with shipping lanes vital to the economies of many of the world's nations.

In the developing ears of opossums, echoes of evolutionary history When we are confronted with the remarkable diversity and complexity of forms among living things—the lightweight and leathery wings of a bat, the dense networks of genes that work together to produce a functional cell—it can be hard to imagine how chance mutations and selective processes produced them. If we could rewind evolutionary time, what would we see?

U.S. teens in poverty go hungry so siblings can eat A survey of about 1,500 extremely disadvantaged families in Boston, Chicago, and San Antonio shows teenagers go without food twice as often as their younger brothers and sisters. Parents first deprive themselves, skipping meals to feed their children. But if there still isn’t enough for everyone, parents will feed younger children before teenagers, regularly leaving the older kids—teen boys in pa

Rare Leptospirosis Cases in NYC: 5 Things to Know Three people in New York City recently became sick with a rare bacterial disease called leptospirosis that they might have contracted from rats.

Physicists harness neglected properties of light University of Toronto (U of T) researchers have demonstrated a way to increase the resolution of microscopes and telescopes beyond long-accepted limitations by tapping into previously neglected properties of light. The method allows observers to distinguish very small or distant objects that are so close together they normally meld into a single blur.

Silver scaffolds grow bone while blocking MRSA Silver ion-coated scaffolds can slow the spread of—or even kill—methicillin-resistant Staphylococcus aureus (MRSA) while growing new bone, say researchers. “Osteomyelitis is a debilitating bone infection that can result when MRSA invades bone tissue, including bone marrow or surrounding soft tissues,” says Elizabeth Loboa, dean of the University of Missouri College of Engineering. “Increasingly,

90 percent of fish used for fishmeal are prime fish Every year for the past 60 years, an average of 20 million tonnes of fish caught in the global ocean have not been used to nourish people.

New, ultra-flexible probes form reliable, scar-free integration with the brain Engineering researchers at The University of Texas at Austin have designed ultra-flexible, nanoelectronic thread (NET) brain probes that can achieve more reliable long-term neural recording than existing probes and don't elicit scar formation when implanted. The researchers described their findings in a research article published on Feb. 15 in Science Advances.

Google Fiber Sheds Workers As It Looks to a Wireless Future The future of high-speed internet from Google will likely involve less fiber.

3-D reconstruction of skull suggests a small crocodile is a new species A small crocodyliform dinosaur may be a new species.

No, that's not a brown recluse spider bite A retired entomologist and two dermatologists who specialize in treating brown recluse bites have co-authored a just-published paper that describes expressions of skin conditions that are often misdiagnosed as bites from the brown recluse spider.

NASA Looks to Speed Timetable for Putting Astronauts in Deep Space The agency’s acting administrator offered the first hints of a notable mission that could lead to a return to the moon in the Trump era.

World's First Self-Driving Tesla Taxis Will Hit the Road in Dubai The United Arab Emirates has purchased a fleet of 200 Tesla vehicles for its taxi program that will have all the hardware needed for fully autonomous driving.

Genome analysis helps keep deadly brain cancer at bay for five years An analysis of a patient’s deadly brain tumor helped doctors identify new emerging mutations and keep a 55-year old woman alive for more than five years, researchers report.

Patient complaints can identify surgeons with higher rates of bad surgical outcomes Recording and analyzing patient and family reports about rude and disrespectful behavior can identify surgeons with higher rates of surgical site infections and other avoidable adverse outcomes, according to a study.

Swishing with mouth rinse may improve athletic performance Endurance athletes looking to improve their times might consider swishing with a mouth rinse that contains a little sugar during their next performance.

The flu gets cold In an effort to one day eliminate the need for an annual flu shot, a group of researchers is exploring the surface of influenza viruses, which are covered by a protein called “hemagglutinin” (HA). This particular protein is used like a key by viruses to open cells and infect them, making it an ideal target for efforts to help the body's immune system fight off a wide range of influenza strains.

DNA patterns can unlock how glucose metabolism drives cancer, study finds Less aggressive cancers are known to have an intact genome–the complete set of genes in a cell–while the genome of more aggressive cancers tends to have a great deal of abnormalities. Now, a new multi-year study of DNA patterns in tumor cells suggests that these aberrant genetic signatures are not random but reflect selective forces in tumor evolution.

Father's diet impacts on son's ability to reproduce, study in flies suggests The view that males just pass on genetic material and not much else to their offspring has now been debunked. Instead, new research found a father's diet can affect their son's ability to out-compete a rival's sperm after mating.

Depression symptoms among men when their partners are pregnant Men who were stressed or in poor health had elevated depression symptoms when their partners were pregnant and nine months after the birth of their child, according to the results of a study of expectant and new fathers in New Zealand.

New antibiotic from bacteria found on Kenyan ant could help beat MRSA A new antibiotic, produced by bacteria found on a species of African ant, is very potent against antibiotic-resistant ‘superbugs’ like MRSA according to scientists.

Alien species on the rise worldwide Although it was known that the number of alien species increased during the last decades, it remained unclear whether or not the accumulation of alien species has already reached a point of slow-down. A new study on the topic has an answer now: for all groups of organisms on all continents, the number of alien species has increased continuously during the last 200 years.

One in four ER visits for eye problems aren't actually emergencies, study finds Pinkeye isn’t a medical emergency. Neither is a puffy eyelid. But a new study finds that nearly one in four people who seek emergency care for eye problems have those mild conditions, and recommends ways to help those patients get the right level of care.

Researchers identify new process to raise natural armies of cancer-targeting T lymphocytes A new culture method has been discovered that unlocks the natural fighter function of immune T cells when they are passing through the bloodstream. This allows T cell armies to be raised directly from blood that naturally recognize and target proteins that are present on most human cancers.

Two new drug therapies might cure every form of tuberculosis In small trials across Africa, the therapies cured people with even the most drug-resistant forms of TB, and more quickly than current treatments

W.E.B. Du Bois, Scientific American and Data Stories of the Early 1900s Two sets of infographics offer distinct perspectives on American life at the turn of the century —

Google's AI Learns Betrayal and "Aggressive" Actions Pay Off Google's DeepMind artificial intelligence learns what it takes to win, making human-like choices in competitive situations.

Tiny 3D-printed camera lens could give drones vision like ours The camera, measuring less than the width of a few human hairs, combines four lenses to mimic the natural vision of predators with precise detail only in the centre of an image

The Mars paradox: Why we still don’t understand water on Mars A 40-year quest to resolve discrepancies between climate models and observations just got another false start. Are we missing something more fundamental?

Universes that spawn ‘cosmic brains’ should go on the scrapheap Weird consciousnesses called Boltzmann brains arise in many cosmological theories – but we now have reason to rule them out unless we live in an old universe

Churchill’s lost essay on alien worlds has a message for us all In 1939 Winston Churchill mused about the possibility of exoplanets and life beyond Earth. His words still resonate today, says Rebecca Boyle

Cancer-Fighting Army? Magnetic Robot Swarms Could Combat Disease Magnetically controlled swarms of microscopic robots might one day help fight cancer inside the body, new research suggests.

Depression Can Affect New Fathers, Too While much attention is given to maternal depression, fathers also can get depressed before and after their child's birth, which, in turn, can have negative consequences for the child.

NASA sees Tropical Cyclone Dineo at Mozambique coast When NASA's Aqua satellite passed over Tropical Cyclone Dineo in the Mozambique Channel on Feb. 15, the storm was centered just off the coast of Mozambique and moving toward landfall.

Team examines the evolution of wooden halibut hooks carved by native people of the Northwest Coast The Tlingit and Haida, indigenous peoples of the Northwest Coast (NWC), have used carved wooden hooks to catch halibut for centuries. As modern fishing technology crept into use, however, the old hooks practically disappeared from the sea. But they thrived on land—as decorative art.

NASA-funded website lets public search for new nearby worlds NASA is inviting the public to help search for possible undiscovered worlds in the outer reaches of our solar system and in neighboring interstellar space. A new website, called Backyard Worlds: Planet 9, lets everyone participate in the search by viewing brief movies made from images captured by NASA's Wide-field Infrared Survey Explorer (WISE) mission. The movies highlight objects that have grad

How temperature guides where species live and where they'll go For decades, among the most enduring questions for ecologists have been: "Why do species live where they do? And what are the factors that keep them there?" A Princeton University-based study featured on the February cover of the journal Ecology could prove significant in answering that question, particularly for animals in the world's temperate mountain areas.

Good vibrations help reveal molecular details Scientists have developed a method to obtain structural details on molecules in lipid membranes near gold nanoparticles. Their method, called SABERS, could help researchers who study drug delivery and amyloid interactions implicated in neurodegenerative disease.

Preventing HIV with PrEP takes these 9 steps The most promising approach to slowing the spread of HIV may be a pill that uninfected people can take to protect themselves. But that strategy only works if people at risk for contracting HIV become and remain fully engaged in preventive care and actually take the pills. In the real world of clinical practice, that has often proved tricky. In a new study, published in the journal AIDS , research

Solar Installations Soared in the U.S. in 2016 And the rate of new wind installations looks primed for a surge in the next few years.

Ice fishing as extreme sport: Burns, broken bones, concussions among injuries chronicled Ice fishing might seem like a benign sport – for everyone except the fish. Sitting in a cozy shanty waiting for a bite, what could go wrong? A lot, surgeons have found. The ice fishing injuries they have chronicled seem more like a casualty list from an extreme sport: burns, broken bones, concussions and more.

People can 'suppress' hay fever with three years of pollen pills or injections Patients blighted by hay fever could markedly reduce symptoms for several years after a three-year course of treatment, but not after two years of treatment, researchers have found.

Communicating health risks in a post-truth world Public officials faced with the tough task of communicating risk on contentious issues like vaccination or fluoridation — where the actual risk is low but public concern remains high — need to show that they care, demonstrate that they are taking action and strategically engage with the media.

Helium from the Big Bang lingers in these hotspots The Earth’s mantle—the layer between the crust and the outer core—is home to a primordial soup even older than the moon. Among the main ingredients is helium-3 (He-3), a vestige of the Big Bang and nuclear fusion reactions in stars. And the mantle is its only terrestrial source. Scientists studying volcanic hotspots have strong evidence of this, finding high helium-3 relative to helium-4 in some

Making sodium-ion batteries that last Lithium-ion batteries have become essential in everyday technology. But these power sources can explode under certain circumstances and are not ideal for grid-scale energy storage. Sodium-ion batteries are potentially a safer and less expensive alternative, but current versions don't last long enough yet for practical use. Now, scientists have developed an anode material that enables sodium-ion ba

Researchers kill brain cancer in mice with combination immunotherapies A combination of drugs known as SMAC Mimetics and immune checkpoint inhibitors (ICIs) amplifies kill rates of cancer tumor cells in laboratory testing.

Hjælp med at finde den næste exoplanet: Du kan også være med! Hvem har ikke lyst til at være med til at opdage en exoplanet, spørger forsker og opfordrer alle til at deltage.

Flowing Fire? How Yosemite Waterfall Appears to Burn It may look like a ribbon of cascading lava, but the so-called "firefall" in Yosemite National Park is actually a regular waterfall illuminated by the bright light of the setting sun.

Scientists report ocean data from under Greenland's Petermann Glacier Based on data from the first ocean sensors deployed under Greenland's Petermann Glacier, researchers report that the floating ice shelf is strongly coupled, or tied, to the ocean below and to the adjacent Nares Strait. Warming temperatures recorded at the deepest ocean sensors match data from Nares Strait, which connects the Arctic and Atlantic oceans.

Engineers shrink microscope to dime-sized device Researchers at The University of Texas at Dallas have created an atomic force microscope on a chip, dramatically shrinking the size—and, hopefully, the price tag—of a high-tech device commonly used to characterize material properties.

When does a man say 'I'm the father'? American men much more readily acknowledge that they are the legal father of a child born out of wedlock when the woman involved is more affluent, educated, and healthy. It also helps (slightly) if the baby is a boy, says Kermyt Anderson of the University of Oklahoma in the US, after scrutinizing data from 5.4 million births in a study published in Springer's journal Human Nature.

Global ocean de-oxygenation quantified The ongoing global change causes rising ocean temperatures and changes the ocean circulation. Therefore less oxygen is dissolved in surface waters and less oxygen is transported into the deep sea. This reduction of oceanic oxygen supply has major consequences for the organisms in the ocean. Scientists have now published the most comprehensive analysis on oxygen loss in the world's oceans and their

Scientists discover how epithelial cells maintain constant cell numbers New research shows how epithelial cells naturally turn over, maintaining constant numbers between cell division and cell death.

A cultural catch: Evolution of wooden halibut hooks carved by native people of the northwest coast A scholar has examined the evolution of wooden halibut hooks carved by native people of the Northwest Coast.

How temperature guides where species live, where they'll go A new study could prove significant in answering among the most enduring questions for ecologists: Why do species live where they do, and what are the factors that keep them there? The ranges of animals in the world's temperate mountain areas — often presumed to be determined by competition — may actually be determined more by temperature and habitat. The findings indicate that species living in

Scientists take aim at obesity-linked protein Scientists have shown that deleting the gene for this protein, known as IP6K1, protects animal models from both obesity and diabetes.

New pathway for Greenland meltwater to reach ocean Cracks in the Greenland Ice Sheet let one of its aquifers drain to the ocean, new NASA research finds. The aquifers, discovered only recently, are unusual in that they trap large amounts of liquid water within the ice sheet. Until now, scientists did not know what happened to the water stored away in this reservoir — the discovery will help fine tune computer models of Greenland's contribution to

Skills to pay the bills?

Cliff driving

Redox-based reagents for chemoselective methionine bioconjugation Cysteine can be specifically functionalized by a myriad of acid-base conjugation strategies for applications ranging from probing protein function to antibody-drug conjugates and proteomics. In contrast, selective ligation to the other sulfur-containing amino acid, methionine, has been precluded by its intrinsically weaker nucleophilicity. Here, we report a strategy for chemoselective methionine

Solving the quantum many-body problem with artificial neural networks The challenge posed by the many-body problem in quantum physics originates from the difficulty of describing the nontrivial correlations encoded in the exponential complexity of the many-body wave function. Here we demonstrate that systematic machine learning of the wave function can reduce this complexity to a tractable computational form for some notable cases of physical interest. We introduce

Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes We introduce MINFLUX, a concept for localizing photon emitters in space. By probing the emitter with a local intensity minimum of excitation light, MINFLUX minimizes the fluorescence photons needed for high localization precision. In our experiments, 22 times fewer fluorescence photons are required as compared to popular centroid localization. In superresolution microscopy, MINFLUX attained ~1-nm

On the deep-mantle origin of the Deccan Traps The Deccan Traps in west-central India constitute one of Earth’s largest continental flood basalt provinces, whose eruption played a role in the Cretaceous-Paleogene extinction event. The unknown mantle structure under the Indian Ocean at the start of the Cenozoic presents a challenge for connecting the event to a deep mantle origin. We used a back-and-forth iterative method for time-reversed con

Double-heterojunction nanorod light-responsive LEDs for display applications Dual-functioning displays, which can simultaneously transmit and receive information and energy through visible light, would enable enhanced user interfaces and device-to-device interactivity. We demonstrate that double heterojunctions designed into colloidal semiconductor nanorods allow both efficient photocurrent generation through a photovoltaic response and electroluminescence within a single

Deterministic entanglement generation from driving through quantum phase transitions Many-body entanglement is often created through the system evolution, aided by nonlinear interactions between the constituting particles. These very dynamics, however, can also lead to fluctuations and degradation of the entanglement if the interactions cannot be controlled. Here, we demonstrate near-deterministic generation of an entangled twin-Fock condensate of ~11,000 atoms by driving a rubid

Lifetime of the solar nebula constrained by meteorite paleomagnetism A key stage in planet formation is the evolution of a gaseous and magnetized solar nebula. However, the lifetime of the nebular magnetic field and nebula are poorly constrained. We present paleomagnetic analyses of volcanic angrites demonstrating that they formed in a near-zero magnetic field (

Decoupled ecomorphological evolution and diversification in Neogene-Quaternary horses Evolutionary theory has long proposed a connection between trait evolution and diversification rates. In this work, we used phylogenetic methods to evaluate the relationship of lineage-specific speciation rates and the mode of evolution of body size and tooth morphology in the Neogene and Quaternary radiation of horses (7 living and 131 extinct species). We show that diversification pulses are a

Gene duplication can impart fragility, not robustness, in the yeast protein interaction network The maintenance of duplicated genes is thought to protect cells from genetic perturbations, but the molecular basis of this robustness is largely unknown. By measuring the interaction of yeast proteins with their partners in wild-type cells and in cells lacking a paralog, we found that 22 out of 56 paralog pairs compensate for the lost interactions. An equivalent number of pairs exhibit the oppos

Activity-dependent spatially localized miRNA maturation in neuronal dendrites MicroRNAs (miRNAs) regulate gene expression by binding to target messenger RNAs (mRNAs) and preventing their translation. In general, the number of potential mRNA targets in a cell is much greater than the miRNA copy number, complicating high-fidelity miRNA-target interactions. We developed an inducible fluorescent probe to explore whether the maturation of a miRNA could be regulated in space and

TZAP: A telomere-associated protein involved in telomere length control Telomeres are found at the end of chromosomes and are important for chromosome stability. Here we describe a specific telomere-associated protein: TZAP (telomeric zinc finger–associated protein). TZAP binds preferentially to long telomeres that have a low concentration of shelterin complex, competing with the telomeric-repeat binding factors TRF1 and TRF2. When localized at telomeres, TZAP trigge

A switch from canonical to noncanonical autophagy shapes B cell responses Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during viral infection. In contrast to mechanistic target of rapamycin complex 1–dependent canonical autophagy, GC B cell autophagy occurred predominantly throu

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Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) efficiently generate all embryonic cell lineages but rarely generate extraembryonic cell types. We found that microRNA miR-34a deficiency expands the developmental potential of mouse pluripotent stem cells, yielding both embryonic and extraembryonic lineages and strongly inducing MuERV-L (MERVL) endogenous retroviruses, simila

Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems Conservation of species and ecosystems is increasingly difficult because anthropogenic impacts are pervasive and accelerating. Under this rapid global change, maximizing conservation success requires a paradigm shift from maintaining ecosystems in idealized past states toward facilitating their adaptive and functional capacities, even as species ebb and flow individually. Developing effective str

A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline The human microbiome encodes vast numbers of uncharacterized enzymes, limiting our functional understanding of this community and its effects on host health and disease. By incorporating information about enzymatic chemistry into quantitative metagenomics, we determined the abundance and distribution of individual members of the glycyl radical enzyme superfamily among the microbiomes of healthy h

Erratum for the Letter "The promise of negative emissions" by K. S. Lackner and 45 additional signatories

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News at a glance

From a tweet, a March for Science is born

Grad students, postdocs with U.S. visas face uncertainty

World's most endangered marine mammal down to 30

New Zealand's endemic dolphins are hanging by a thread

Debate heats up over black holes as dark matter

Why are grizzlies dying on Canada's railway tracks?

A matter of fact

Rules of evidence

Politics vs. data on needle swaps

Clear findings, smoggy debate

No easy answers

Putting the brakes on highway deaths

A simple recipe for saving lives

Genetic divide

How to be heard

Data for all?

Science advice in the Trump White House

Finding enzymes in the gut metagenome

TZAP or not to zap telomeres

Machine learning for quantum physics

Mobile elements control stem cell potency

Flipping nanoscopy on its head

Measurement error and the replication crisis

M. G. K. Menon (1928-2016)

Game changers

Revealing Rorschach

Convergence: The future of health

Precaution: Open gene drive research

Precaution: Risks of public participation

Meteorite magnetism in the early solar system

What drives divergence?

Double trouble for the Deccan Traps

Robustness of protein networks

Intraneuronal control of protein expression

A target for intracranial aneurysms

Starving the pathogen

Transitional approach to entanglement

A protein to trim too-long telomeres

A radical idea for blood pressure control

Change for good

Looking back to move forward

Superresolution imaging in sharper focus

Limiting potential for totipotency

Machine learning and quantum physics

Chemically guided functional profiling

Targeting proteins at the other sulfur

Misconceptions about measurement error

Multifunctional displays

Regrow like an axolotl

Interfering with bad cholesterol

Gluing up hemagglutinin

Child growth sensitivity to rainfall variability

Fluorine frolicking with eight friends

Deep reefs unlikely to save shallow coral reefs Dr Pim Bongaerts, a Research Fellow at The University of Queensland's Global Change Institute (GCI) and ARC Centre of Excellence for Coral Reef Studies, and lead author of the study, said deep reefs share coral species with the shallow reef, which has led to the idea that deep reefs could be an important source of larvae and help to 'reseed' shallow reefs.

3-D reconstruction of skull suggests a small crocodile is a new species A small crocodile discovered in Germany's Langenberg Quarry may be a new species, according to a study published February 15, 2017 in the open-access journal PLOS ONE by Daniela Schwarz from Leibniz Institute for Evolutionary and Biodiversity Research, Germany, and colleagues.

Old rocks, biased data: Overcoming challenges studying the geodynamo Gleaning data from old rocks may result in bias. Now, geophysicists have a way to improve their methods to overcome challenges in studying the history of the Earth's core and magnetic field that make up the geodynamo.

Churchill's search for ET War correspondent, statesman, astronomer. Stargazing may not be what Winston Churchill is best remembered for, but a treatise he wrote on extraterrestrial life has revealed his scientific acumen six decades later.

Alzheimer's Drug Fails in Another Crushing Disappointment Merck halts a late-stage trial of verubecestat, which targeted an enzyme involved in brain plaque formation —

Churchill's Extraterrestrials Astrophysicist and author Mario Livio writes in the journal Nature and talks to Scientific American about the recently rediscovered essay by Winston Churchill that analyzed with impressive scientific… —

Winston Churchill, Astrobiologist In 1939, he wrote presciently about the possibilities of extraterrestrial life in a way modern scientists can admire —

Another Big Health Insurer Loosens Rules For Covering Addiction Treatment Doctors treating people addicted to opioids often need approval from insurers before giving drugs that ease withdrawal. The delay can be risky for patients. Insurers are starting to come around.

Evidence of brain damage found in former soccer players Evidence of chronic traumatic encephalopathy (CTE), a potential cause of dementia caused by repeated blows to the head, has been found in the brains of former association football (soccer) players.

How to roll a nanotube: Demystifying carbon nanotubes' structure control A key advancement in the design of high performance carbon-based electronics has been made by scientists, outlines a new report.

The Forensic Mathematics Behind the Desperate Search for the Malaysia Airlines Plane The search for MH370 has been based on just a few tiny scraps of data. Now anyone can study the analysis to see if anything has been overlooked.

Using 'Scotch tape' and laser beams, researchers craft new material that could improve LED screens Researchers report a new bilayer material, with each layer measuring less than one nanometer in thickness, that someday could lead to more efficient and versatile light emission.

Deadly spider's unique spinning technique could inspire tougher materials The unique spinning technique used by the venomous American brown recluse spider could inspire scientific developments and improve materials used in space travel, suggest scientists.

The Trump Presidency's Potential Impact On Climate Change ProPublica senior reporter Andrew Revkin discusses President Trump's possible cuts to the EPA, as well as the potential impact of pulling out of the Paris climate accord.

Winston Churchill on Aliens: 1939 Essay Discovered Winston Churchill was known for his leadership during World War II, but a newfound essay on alien life reveals another side of him, one that was deeply curious about the universe.

Winston Churchill Wrote of Alien Life in a Lost Essay At the onset of World War II, he took the time to write a scientific paper about the probability of life elsewhere in the universe.

Do We Need a Digital Geneva Convention? Microsoft calls for an international treaty to prevent companies and citizens from getting tangled up in nation-state cyberattacks.

Aliens are probably out there, according to Winston Churchill Space A newly-investigated essay from 1939 reveals Churchill's thoughts on E.T. In 1939, the year World War II broke out, Winston Churchill had aliens on his mind.

Winston Churchill havde en ukendt interesse for liv i universet I et nyligt genfundet dokument fra Winston Churchill skriver den britiske politiker begavet om muligheden for at finde liv andre steder i universet.

You can fake a healthy skin tone to look more attractive (without actually being healthier) Health Beauty really is only skin deep You don’t actually have to be healthier to seem attractive to people—you just have to look healthier. And also apparently we find yellow-ish skin attractive.

Winston Churchill's views on aliens revealed in lost essay A newly unearthed essay by Winston Churchill reveals he was open to the possibility of life on other planets.

How to roll a nanotube: Demystifying carbon nanotubes' structure control Pioneering research published in Nature by Professor Feng Ding's team from the Center for Multidimensional Carbon Materials, within the Institute for Basic Science (IBS), in collaboration with Professor Jin Zhang's team, at Peking University and colleagues, has demonstrated how to control the synthesis of special tiny carbon cylinders known as carbon nanotubes (CNTs), in order to synthesize horizo

How an Ice Age paradox could inform sea level rise predictions New findings from the University of Michigan explain an Ice Age paradox and add to the mounting evidence that climate change could bring higher seas than most models predict.

The Nerdy Charm of Artisanal, Hand-Drawn Infographics Computers? Pah. These designers craft beautiful infographics by hand.

Encryption Apps Help White House Staffers Leak—and Maybe Break the Law An encrypted chat app called Confide has taken over Capitol Hill and the White House, but what will mean for transparency? The post Encryption Apps Help White House Staffers Leak—and Maybe Break the Law appeared first on WIRED .

Astronomers Snap Supernova's Baby Pictures Images of an exploding dying star taken just a few hours after its detonation are revealing new details of stellar death —

Snake vs. Snake: Video Captures Aussie Reptiles Dueling to the Death A highly venomous brown snake and a red-bellied black snake become entangled in a lethal encounter in South Australia.

Deadly spider's unique spinning technique could inspire tougher materials Brown recluse spiders use a unique micro looping technique to make their threads stronger than that of any other spider, a newly published UK-US collaboration has discovered.

Psychopaths Do Feel Regret – But Only After They’ve Crossed the Line, Harvard Study Shows They have the same feelings as normal people. It’s how they make decisions that’s different.

Melatonin content of supplements varies widely, study finds The melatonin content of dietary supplements often varies widely from what is listed on the label, a new study has found. Melatonin is a natural hormone that helps regulate the daily cycle of sleep and wakefulness, with melatonin production increasing at night and decreasing in the morning. It also is widely available as a dietary supplement.

Black-hole-powered jets forge fuel for star formation Astronomers have discovered a surprising connection between a supermassive black hole and the galaxy where it resides. Powerful radio jets from the black hole – which normally suppress star formation – are stimulating the production of cold gas in the galaxy's extended halo of hot gas. This newly identified supply of cold, dense gas could eventually fuel future star birth as well as feed the black

Optimizing data center placement, network design to strengthen cloud computing Telecommunication experts estimate the amount of data stored 'in the cloud' or in remote data centers around the world, will quintuple in the next five years. Whether it's streaming video or business' database content drawn from distant servers, all of this data is — and will continue in the foreseeable future to be — accessed and transmitted by lasers sending pulses of light along long bundles

2017 Kia Niro is most affordable hybrid SUV Kia's newest vehicle, the 2017 Niro, is the lowest-priced, gasoline-electric hybrid SUV on the market and is rated as high as 50 miles per gallon in combined city/highway travel.

Experts say European proposal limits ability to protect public from endocrine disruptors University of Massachusetts Amherst biologist Thomas Zoeller, an internationally recognized expert in the health effects of endocrine-disrupting chemicals, with the Washington, D.C.-based Endocrine Society, this week expressed disappointment in the European Commission's revised proposal on defining and identifying endocrine-disrupting chemicals, citing unnecessarily narrow criteria for identifying

New report examines role of engineering technology, calls for increased awareness While workers in the engineering technology (ET) field play an important role in supporting U.S. technical infrastructure and the country's capacity for innovation, there is little awareness of ET as a field of study or category of employment in the U.S., says a new report from the National Academy of Engineering.

New synchrotron powder diffraction facility for long running experiments Synchrotron beamlines and their instruments are built to harness the photon beam power of synchrotron radiation (SR), which has special properties – ideally suited to providing detailed and accurate structural information that is difficult to obtain from conventional sources. The common modus operandi for such facilities is that users are allocated a short duration of beamtime, typically a few hou

Study identifies new pathway for Greenland meltwater to reach ocean Cracks in the Greenland Ice Sheet let one of its aquifers drain to the ocean, new NASA research finds. The aquifers, discovered only recently, are unusual in that they trap large amounts of liquid water within the ice sheet. Until now, scientists did not know what happened to the water stored away in this reservoir—the discovery will help fine tune computer models of Greenland's contribution to se

NASA wants to put astronauts on the very first launch of its new mega-rocket Space The Space Launch System could carry astronauts as soon as 2019 NASA may change the SLS launch schedule in order to but humans onboard.

Scientists report ocean data from under Greenland's Petermann Glacier In August 2015, University of Delaware oceanographer Andreas Muenchow and colleagues deployed the first UD ocean sensors underneath Petermann Glacier in North Greenland, which connects the great Greenland ice sheet directly with the ocean.

Interface between insulators enables information transport by spin Modern computer technology is based on the transport of electric charge in semiconductors. But this technology's potential will be reaching its limits in the near future, since the components deployed cannot be miniaturized further. But, there is another option: using an electron's spin, instead of its charge, to transmit information. A team of scientists from Munich and Kyoto is now demonstrating

OSIRIS-REx takes closer image of Jupiter During Earth-Trojan asteroid search operations, the PolyCam imager aboard NASA's OSIRIS-REx spacecraft captured this image of Jupiter (center) and three of its moons, Callisto (left), Io, and Ganymede.

Dormouse might be first tree-climbing mammal shown to echolocate It's not just bats that navigate at night using a form of sonar – so might a dormouse, and if so it could tell us whether bats' echolocation preceded flight

Emergency clause lets European countries beat bee pesticide ban About half of the European Union’s member states are making use of an emergency clause to allow the use of banned pesticides that are thought to harm bees

'Tis better to give, to your spouse The emotional benefits of compassionate acts are significant for the giver, whether or not the recipient is even aware of the act, psychologists have found.

Space Poop Problem-Solvers Take Home Cash Prizes From NASA NASA was looking for help from the public in solving a very specific challenge: How to deal with poop in a spacesuit. The winners included doctors, a dentist, a product designer and an engineer.

Feeling Way More Stressed Out? You're Not Alone A January poll finds that people's stress levels have spiked since August, with two-thirds of people saying they're worried about the future of the nation.

When choosing your next move, your brain is always ready for plan B Whether we're navigating a route to work or browsing produce at the grocery store, our brains are constantly making decisions about movement: Should I cross the street now or at the intersection? Should I reach for the red apple or the green apple? When you're presented with two options, your brain's motor neurons prep for both possibilities before you've decided which action to take, say research

Are big ups and downs normal for forage fish? Forage fish stocks have undergone fluctuation swings for hundreds of years, research shows, with at least three species off the US West Coast repeatedly experiencing steep population increases followed by declines long before commercial fishing began. The rise and fall of Pacific sardine, northern anchovy, and Pacific hake off California have been so common that the species were in collapsed cond

3 ways to fix a broken news industry | Lara Setrakian Something is very wrong with the news industry. Trust in the media has hit an all-time low; we're inundated with sensationalist stories, and consistent, high-quality reporting is scarce, says journalist and entrepreneur Lara Setrakian. She shares three ways we can fix the news and make the complex issues of our time easier to understand.

NASA's OSIRIS-REx takes its first image of Jupiter This image was taken at 3:38 a.m. EST on Feb. 9, 2017, when the spacecraft was 75 million miles (120 million kilometers) from Earth and 419 million miles (675 million kilometers) from Jupiter. With an exposure time of two seconds, the image renders Jupiter overexposed, but allows for enhanced detection of stars in the background.

Beach bashing: Last year's El Niño resulted in unprecedented erosion of Pacific coastline Last winter's El Niño might have felt weak to residents of Southern California, but it was in fact one of the most powerful climate events of the past 145 years. If such severe El Niño events become more common in the future as some studies suggest they might, the California coast — home to more than 25 million people — may become increasingly vulnerable to coastal hazards. And that's independen

The maths problems that could win you a million dollars Six of the seven Millennium Prize problems remain unsolved, but cracking any one of them would be a major – and financially rewarding – achievement

New economic water-splitting catalyst: Ruthenium-based material Researchers in South Korea have developed an exiting new catalyst — a ruthenium (Ru)-based material — that can split water into hydrogen almost as well as platinum can.

Risk of rapid North Atlantic cooling in 21st century greater than previously estimated The possibility of major climate change in the Atlantic region has long been recognized and has even been the subject of a Hollywood movie: The Day After Tomorrow. To evaluate the risk of such climate change, researchers developed a new algorithm to analyze the 40 climate models considered by the latest report from the Intergovernmental Panel on Climate Change (IPCC). Their findings raise the prob

GameSpace offers a playable visualization of 16,000 videogames Finding information about videogames can now be a game in itself, thanks to researchers. They created GameSpace, a playable visualization of 16,000 videogames grouped according to common features and displayed in 3-dimensional space like a vast galaxy of games available for exploration.

Oroville Dam Evacuations Lifted As Officials Say Structure Can Withstand Next Storm People who live downstream of the Northern California dam were allowed to return to their homes more than two days after the structure's concrete spillways suffered serious water damage.

A small city in Iowa is devoting 1,000 acres of land to America's vanishing bees Animals Little habitats on the prairie to save our nation's pollinators The nation's bees are in trouble, and a small city in Iowa is doing something about it.

Climate Change Has Already Harmed Almost Half of All Mammals Researchers found the range of wildlife now affected by climate change is broad, and includes animals on every continent —

Brain study: Motor cortex contributes to word comprehension Researchers have experimentally confirmed the hypothesis, whereby comprehension of a word's meaning involves not only the 'classic' language brain centers but also the cortical regions responsible for the control of body muscles, such as hand movements. The resulting brain representations are, therefore, distributed across a network of locations involving both areas specialized for language proces

'The blob' of abnormal conditions boosted Western US ozone levels Ozone levels in June 2015 were significantly higher than normal over a large swath of the Western US. Analysis ties this air quality pattern to the abnormal conditions in the northeast Pacific Ocean, nicknamed 'the blob.'

Scientists show 'matchmaker' role for protein behind SMA Cell biologists have a detailed picture for what they think the SMN (survival of motor neurons) protein is doing, and how its deficiency causes problems in SMA patients' cells. This new work could inform delivery of treatments, they say.

A new contrast agent for MRI A specially coated iron oxide nanoparticle could provide an alternative to conventional gadolinium-based contrast agents used for magnetic resonance imaging (MRI). In rare cases, the currently used gadolinium agents have been found to produce adverse effects in patients with impaired kidney function.

Shock from heart device often triggers further health care needs Shock from an implantable cardioverter defibrillator (ICD) may trigger an increase in health care needs for many patients, regardless whether the shock was appropriate needed or not. Whether the shock was appropriate or inappropriate patients often underwent invasive cardiac procedures afterward. Programming strategies that reduce ICD shocks may reduce healthcare costs and improve patient health.

Researchers identify phosphorylation process vital to cancer growth Scientists have identified a new mechanism that impacts tumor growth. The typical lack of oxygen in tumors doesn't only stimulate proliferation, but also offsets the important role of the protein PHD2 as 'cancer cell killer.' A possible solution lies in blocking the enzyme PP2A/B55, which restores the function of PHD2 and consequently slows down cancer growth, say researchers.

Sick and tired: Not just a figure of speech Already feeling drained so early in the year? Genes might contribute in a small but significant way to whether people report being tired and low in energy, according to new research.

El Niño swept away huge chunks of the west coast last winter Environment And climate change could make it worse In January of last year, drones captured video of houses perched perilously on rapidly eroding cliffs along California’s coast. Those houses in Pacifica, California…

EU issues 'final warning' to Britain, France on air pollution The EU ordered five member countries including Britain, France and Germany to tighten controls on smog-causing car pollution or risk being sent to the top European court.

Amazon’s Vision of Drone Deliveries Now Involves Parachutes Why bother to land when you can toss parcels from the sky instead?

Is a stretchable smart tablet in our future? Engineering researchers have developed the first stretchable integrated circuit that is made entirely using an inkjet printer, raising the possibility of inexpensive mass production of smart fabric.

New Doppler sound database could help those suffering from heart conditions Handheld devices can scan the lower limbs of a patient and 'listen' to the blood flow, providing vital early indication of problems that could lead to strokes or heart attacks. But inexperience or lack of training sometimes mean that clinicians do not properly interpret what they hear and therefore miss the warning signs. Now a new research project aims to build a digital library of the different

Closer look at atomic motion in molecules may benefit biotech researchers Every molecule holds a complex landscape of moving atoms – and the ability to single out and examine individual nuclear vibrations may unlock to the secret to predicting and controlling chemical reactions. Now a new method enables biotech researchers to do just that.

Unlocking the genetic secrets of legendary bulls Researchers are are unpacking the entire DNA sequences of 50 influential animals dating back to the 1950s, then honing in on the genes associated with specific traits in order to capture the best genetics in the Brahman breed.

Spread of lionfish in Gulf of Mexico is threat to reef fisheries As the old saying goes: "You can't put the genie back in the bottle." Nowhere is this more evident than with the spread of lionfish, an invasive, non-native species that is threatening the marine ecosystems across the Gulf of Mexico, Caribbean and Atlantic Ocean.

Long-term eelgrass loss due to joint effects of shade, heat A new study links a long-term decline in Chesapeake Bay's eelgrass beds to both deteriorating water quality and rising summertime temperatures. It also shows that loss of the habitat and other benefits that eelgrass provides comes at a staggering ecological and economic cost.

Laissez-faire is not good enough for reforestation If degraded and logged areas of tropical forests are left to nature, the populations of certain endangered tree species are not able to recover. This applies in particular to trees with large fruit where the seeds are distributed by birds, as ETH Zurich scientists have shown in a rainforest in India.

Scientists combine disciplines to pinpoint small structures in unlabeled molecules Five years of hard work and a little "cosmic luck" led Rice University researchers to a new method to obtain structural details on molecules in biomembranes.

Extreme waves caught with higher-resolution modeling A new study shows that high-resolution models captured hurricanes and big waves that low-resolution ones missed. Better extreme wave forecasts are important for coastal cities, the military, the shipping industry, and surfers.

Nanotechnology based gene editing to eradicate HIV brain reservoir in drug abusers Opiate abuse is a significant risk factor for HIV infection, and in combination they can have a devastating effect on the brain. Scientists at FIU Herbert Wertheim College of Medicine (HWCOM) are studying new therapies that can short-circuit HIV infection and mitigate the damaging effects that opiate addiction has on the central nervous system.

Species new to science named after a 'Dungeons & Dragons' character Focused on terrestrial gastropods, more commonly known as land snails, a joint team of biologists from the Natural History Museum of Stuttgart, Germany and the Zoology Museum of São Paulo, Brazil, have been researching the Brazilian caves. In their latest paper, published in the journal Zoosystematics and Evolution, the scientists describe the fauna from several caves in central Brazil, including

Check Out This Awesome Crash Test. Now, Let’s Run the Physics This car barrier has rollers built into it to reduce the car impact along the direction of the rail. In this video analysis, I will calculate the acceleration of an impacting car.

Koldkrigsfly får laservåben Det amerikanske forsvar vil udstyre de gamle B-52-bombefly med lasere, der forventes klar i 2023.

'Disturbing' Results Show High Pollution Levels in Mariana Trench The vast underwater wilderness of the deep sea may be largely unexplored by humans, but it's still incredibly polluted, a new study finds.

Deadly Cocktail: Ancient Mammal-Like Reptiles Were 1st to Use Venom The world's first venomous animal wasn't a scorpion, a jellyfish or even a snake, but a mammal-like, cat-size reptile that lived before the dinosaur age in what is now South Africa, a new study finds.

How to get Wi-Fi to every corner of your house DIY Death to dead zones You've probably got more than one device in your home that relies on the internet. Here's how to make sure you're always getting a strong signal.

Monitoring birds by drone Forget delivering packages or taking aerial photographs — drones can even count small birds. A new study tests this new approach to wildlife monitoring and concludes that despite some drawbacks, the method has the potential to become an important tool for ecologists and land managers.

Some marine creatures may be more resilient to harsher ocean conditions than expected As the world continually emits carbon dioxide into the atmosphere, the oceans are taking a hit, absorbing some of it and growing more acidic. Among other effects, scientists have found that coral reefs and oyster hatcheries are deteriorating as a result. However, scientists studying a type of sea snail report a bit of bright news: The animal can adapt by rejiggering its shell-making process and ot

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